Neurocognitive development in first episode psychosis 5 years follow-up: Associations between illness severity and cognitive course

Helene Eidsmo Barder, Kjetil Sundet, Bjørn Rishovd Rund, Julie Evensen, Wenche ten Velden Hegelstad, Inge Joa, Jan Olav Johannessen, Hans Langeveld, T.K. Larsen, Ingrid Melle, Stein Opjordsmoen, Jan Ivar Røssberg, Erik Simonsen, Per Vaglum, Thomas McGlashan, Svein Friis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Cognitive deficits are documented in first-episode psychosis (FEP), but the continuing course is not fully understood.
    The present study examines the longitudinal development of neurocognitive function in a five year follow-up of FEP-patients, focusing on the relation to illness severity, as measured by relapses and diagnostic subgroups. The study is an extension of previous findings from the TIPS-project, reporting stability over the first two years.
    Sixty-two FEP patients (53% male, age 28 ± 9 years) were neuropsychologically examined at baseline and at 1, 2, and 5 year follow-ups. The test battery was divided into five indices; Verbal Learning, Executive Function, Impulsivity,
    Motor Speed, andWorking Memory. To investigate the effect of illness severity, the sample was divided in groups based on number of relapses, and diagnostic subgroups, respectively.
    Impulsivity and Working Memory improved significantly in the first two years, followed by no change over the next three years.Motor Speed decreased significantly from2 to 5 years. Number of relapseswas significantly related
    to Verbal Learning and WorkingMemory, showing a small decrease and less improvement, respectively, in patients with two or more episodes. No significant association was found with diagnostic group.
    Neurocognitive stability as well as change was found in a sample of FEP-patients examined repeatedly over 5 years. Of potential greater importance for understanding howpsychotic illnesses progress, is the finding of significant
    associations between neurocognition and number of relapses but not diagnostic group, indicating that neurocognition is more related to recurring psychotic episodes than to the descriptive diagnosis per se.
    OriginalsprogEngelsk
    TidsskriftSchizophrenia Research
    Vol/bind149
    Udgave nummer1-3
    Sider (fra-til)63-69
    ISSN0920-9964
    DOI
    StatusUdgivet - 2013

    Emneord

    • Neurocognition
    • First-episode psychosis
    • Longitudinal course
    • Relapse
    • Diagnosis

    Citer dette

    Barder, Helene Eidsmo ; Sundet, Kjetil ; Rund, Bjørn Rishovd ; Evensen, Julie ; Hegelstad, Wenche ten Velden ; Joa, Inge ; Johannessen, Jan Olav ; Langeveld, Hans ; Larsen, T.K. ; Melle, Ingrid ; Opjordsmoen, Stein ; Røssberg, Jan Ivar ; Simonsen, Erik ; Vaglum, Per ; McGlashan, Thomas ; Friis, Svein. / Neurocognitive development in first episode psychosis 5 years follow-up : Associations between illness severity and cognitive course. I: Schizophrenia Research. 2013 ; Bind 149, Nr. 1-3. s. 63-69.
    @article{04af627535624f2f95b436c4c0dd06fe,
    title = "Neurocognitive development in first episode psychosis 5 years follow-up: Associations between illness severity and cognitive course",
    abstract = "Cognitive deficits are documented in first-episode psychosis (FEP), but the continuing course is not fully understood.The present study examines the longitudinal development of neurocognitive function in a five year follow-up of FEP-patients, focusing on the relation to illness severity, as measured by relapses and diagnostic subgroups. The study is an extension of previous findings from the TIPS-project, reporting stability over the first two years.Sixty-two FEP patients (53{\%} male, age 28 ± 9 years) were neuropsychologically examined at baseline and at 1, 2, and 5 year follow-ups. The test battery was divided into five indices; Verbal Learning, Executive Function, Impulsivity,Motor Speed, andWorking Memory. To investigate the effect of illness severity, the sample was divided in groups based on number of relapses, and diagnostic subgroups, respectively.Impulsivity and Working Memory improved significantly in the first two years, followed by no change over the next three years.Motor Speed decreased significantly from2 to 5 years. Number of relapseswas significantly relatedto Verbal Learning and WorkingMemory, showing a small decrease and less improvement, respectively, in patients with two or more episodes. No significant association was found with diagnostic group.Neurocognitive stability as well as change was found in a sample of FEP-patients examined repeatedly over 5 years. Of potential greater importance for understanding howpsychotic illnesses progress, is the finding of significantassociations between neurocognition and number of relapses but not diagnostic group, indicating that neurocognition is more related to recurring psychotic episodes than to the descriptive diagnosis per se.",
    keywords = "Neurocognition, First-episode psychosis, Longitudinal course, Relapse, Diagnosis",
    author = "Barder, {Helene Eidsmo} and Kjetil Sundet and Rund, {Bj{\o}rn Rishovd} and Julie Evensen and Hegelstad, {Wenche ten Velden} and Inge Joa and Johannessen, {Jan Olav} and Hans Langeveld and T.K. Larsen and Ingrid Melle and Stein Opjordsmoen and R{\o}ssberg, {Jan Ivar} and Erik Simonsen and Per Vaglum and Thomas McGlashan and Svein Friis",
    year = "2013",
    doi = "10.1016/j.schres.2013.06.016",
    language = "English",
    volume = "149",
    pages = "63--69",
    journal = "Schizophrenia Research",
    issn = "0920-9964",
    publisher = "Elsevier BV",
    number = "1-3",

    }

    Barder, HE, Sundet, K, Rund, BR, Evensen, J, Hegelstad, WTV, Joa, I, Johannessen, JO, Langeveld, H, Larsen, TK, Melle, I, Opjordsmoen, S, Røssberg, JI, Simonsen, E, Vaglum, P, McGlashan, T & Friis, S 2013, 'Neurocognitive development in first episode psychosis 5 years follow-up: Associations between illness severity and cognitive course' Schizophrenia Research, bind 149, nr. 1-3, s. 63-69. https://doi.org/10.1016/j.schres.2013.06.016

    Neurocognitive development in first episode psychosis 5 years follow-up : Associations between illness severity and cognitive course. / Barder, Helene Eidsmo; Sundet, Kjetil; Rund, Bjørn Rishovd; Evensen, Julie; Hegelstad, Wenche ten Velden; Joa, Inge; Johannessen, Jan Olav; Langeveld, Hans; Larsen, T.K.; Melle, Ingrid; Opjordsmoen, Stein; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas; Friis, Svein.

    I: Schizophrenia Research, Bind 149, Nr. 1-3, 2013, s. 63-69.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Neurocognitive development in first episode psychosis 5 years follow-up

    T2 - Associations between illness severity and cognitive course

    AU - Barder, Helene Eidsmo

    AU - Sundet, Kjetil

    AU - Rund, Bjørn Rishovd

    AU - Evensen, Julie

    AU - Hegelstad, Wenche ten Velden

    AU - Joa, Inge

    AU - Johannessen, Jan Olav

    AU - Langeveld, Hans

    AU - Larsen, T.K.

    AU - Melle, Ingrid

    AU - Opjordsmoen, Stein

    AU - Røssberg, Jan Ivar

    AU - Simonsen, Erik

    AU - Vaglum, Per

    AU - McGlashan, Thomas

    AU - Friis, Svein

    PY - 2013

    Y1 - 2013

    N2 - Cognitive deficits are documented in first-episode psychosis (FEP), but the continuing course is not fully understood.The present study examines the longitudinal development of neurocognitive function in a five year follow-up of FEP-patients, focusing on the relation to illness severity, as measured by relapses and diagnostic subgroups. The study is an extension of previous findings from the TIPS-project, reporting stability over the first two years.Sixty-two FEP patients (53% male, age 28 ± 9 years) were neuropsychologically examined at baseline and at 1, 2, and 5 year follow-ups. The test battery was divided into five indices; Verbal Learning, Executive Function, Impulsivity,Motor Speed, andWorking Memory. To investigate the effect of illness severity, the sample was divided in groups based on number of relapses, and diagnostic subgroups, respectively.Impulsivity and Working Memory improved significantly in the first two years, followed by no change over the next three years.Motor Speed decreased significantly from2 to 5 years. Number of relapseswas significantly relatedto Verbal Learning and WorkingMemory, showing a small decrease and less improvement, respectively, in patients with two or more episodes. No significant association was found with diagnostic group.Neurocognitive stability as well as change was found in a sample of FEP-patients examined repeatedly over 5 years. Of potential greater importance for understanding howpsychotic illnesses progress, is the finding of significantassociations between neurocognition and number of relapses but not diagnostic group, indicating that neurocognition is more related to recurring psychotic episodes than to the descriptive diagnosis per se.

    AB - Cognitive deficits are documented in first-episode psychosis (FEP), but the continuing course is not fully understood.The present study examines the longitudinal development of neurocognitive function in a five year follow-up of FEP-patients, focusing on the relation to illness severity, as measured by relapses and diagnostic subgroups. The study is an extension of previous findings from the TIPS-project, reporting stability over the first two years.Sixty-two FEP patients (53% male, age 28 ± 9 years) were neuropsychologically examined at baseline and at 1, 2, and 5 year follow-ups. The test battery was divided into five indices; Verbal Learning, Executive Function, Impulsivity,Motor Speed, andWorking Memory. To investigate the effect of illness severity, the sample was divided in groups based on number of relapses, and diagnostic subgroups, respectively.Impulsivity and Working Memory improved significantly in the first two years, followed by no change over the next three years.Motor Speed decreased significantly from2 to 5 years. Number of relapseswas significantly relatedto Verbal Learning and WorkingMemory, showing a small decrease and less improvement, respectively, in patients with two or more episodes. No significant association was found with diagnostic group.Neurocognitive stability as well as change was found in a sample of FEP-patients examined repeatedly over 5 years. Of potential greater importance for understanding howpsychotic illnesses progress, is the finding of significantassociations between neurocognition and number of relapses but not diagnostic group, indicating that neurocognition is more related to recurring psychotic episodes than to the descriptive diagnosis per se.

    KW - Neurocognition

    KW - First-episode psychosis

    KW - Longitudinal course

    KW - Relapse

    KW - Diagnosis

    U2 - 10.1016/j.schres.2013.06.016

    DO - 10.1016/j.schres.2013.06.016

    M3 - Journal article

    VL - 149

    SP - 63

    EP - 69

    JO - Schizophrenia Research

    JF - Schizophrenia Research

    SN - 0920-9964

    IS - 1-3

    ER -