Tomato thymidine kinase is subject to inefficient TTP feedback regulation

Bidragets oversatte titel: Nedsat TTP feed-back regulering af Thymidin kinase fra tomater

Nicolai Balle Larsen, Birgitte Munch-Petersen, Jure Piskur

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

    Abstract

    A promising suicide gene therapy system to treat gliomas has been reported: the thymidine kinase 1 from tomato (toTK1) combined with the nucleoside analog pro-drug zidovudine (azidothymidine, AZT), which is known to penetrate the blood-brain barrier. Transduction with toTK1 has been found to efficiently increase the sensitivity of human glioblastoma cells to AZT, and nude rats with intracranial glioblastoma grafts have shown significantly improved survival when treated with the toTK1/AZT system. We show in our paper that the strong suicidal effect of AZT together with toTK1 may be explained by reduced TTP-mediated feedback inhibition of the AZT phosphorylation.
    Bidragets oversatte titelNedsat TTP feed-back regulering af Thymidin kinase fra tomater
    OriginalsprogEngelsk
    TidsskriftNucleosides, Nucleotides and Nucleic Acids
    Vol/bind33
    Udgave nummer4-6
    Sider (fra-til)287-290
    Antal sider4
    ISSN1525-7770
    StatusUdgivet - dec. 2014

    Emneord

    • Antiviral nucleosides
    • anticancer nucleosides
    • carcinogenicity
    • enzyme inhibition
    • enzyme regulation

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