Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis

Solen Kernéis, Pierre-Yves Boëlle, Rebecca Freeman Grais, Gérard Pavillon, Eric Jougla, Antoine Flahault, Lone Simonsen, Thomas Hanslik

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We compared trends of Systemic Sclerosis (SS) mortality in France and the USA over the period 1980-1998 and used an Age-Period-Cohort (APC) model to adjust on the age at death of SS patients. All deaths coded with SS as an underlying primary or secondary cause in the national French and US mortality databases from 1980 to 1998 were included in the analysis. SS age-standardized mortality rates increased from 7.2 to 10.3/million in US women (+43%), and from 3 to 3.9/million in French women (+22%). Most of the increase occurred in senior women. In contrast, SS age-standardized death rates remained stable among US men (around 3/million) and French men (around 2/million). In US women, the APC analysis shows a growing cohort effect between 1900 and 1940, tending to stabilize for following cohorts. Similar findings were obtained to a lesser extent in French women. In conclusion, SS mortality rates increased by more than 40% between 1980 and 1998 in the USA, mostly in women born between 1900 and 1940. Whether these trends reflect rising incidence of SS need to be documented. The observed dissimilarity between genders and countries underline that environmental exposure and gender-related factors likely play a major etiological role. Stabilization in the following birth cohorts suggests that the increase of mortality observed since 1980 may slow down in the near future.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind25
Udgave nummer1
Sider (fra-til)55-61
ISSN0393-2990
StatusUdgivet - 2010

Citer dette

Kernéis, S., Boëlle, P-Y., Freeman Grais, R., Pavillon, G., Jougla, E., Flahault, A., ... Hanslik, T. (2010). Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis. European Journal of Epidemiology, 25(1), 55-61.
Kernéis, Solen ; Boëlle, Pierre-Yves ; Freeman Grais, Rebecca ; Pavillon, Gérard ; Jougla, Eric ; Flahault, Antoine ; Simonsen, Lone ; Hanslik, Thomas. / Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis. I: European Journal of Epidemiology. 2010 ; Bind 25, Nr. 1. s. 55-61.
@article{4438cdf4ecc24c08a1d15a07bf57da79,
title = "Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis",
abstract = "We compared trends of Systemic Sclerosis (SS) mortality in France and the USA over the period 1980-1998 and used an Age-Period-Cohort (APC) model to adjust on the age at death of SS patients. All deaths coded with SS as an underlying primary or secondary cause in the national French and US mortality databases from 1980 to 1998 were included in the analysis. SS age-standardized mortality rates increased from 7.2 to 10.3/million in US women (+43{\%}), and from 3 to 3.9/million in French women (+22{\%}). Most of the increase occurred in senior women. In contrast, SS age-standardized death rates remained stable among US men (around 3/million) and French men (around 2/million). In US women, the APC analysis shows a growing cohort effect between 1900 and 1940, tending to stabilize for following cohorts. Similar findings were obtained to a lesser extent in French women. In conclusion, SS mortality rates increased by more than 40{\%} between 1980 and 1998 in the USA, mostly in women born between 1900 and 1940. Whether these trends reflect rising incidence of SS need to be documented. The observed dissimilarity between genders and countries underline that environmental exposure and gender-related factors likely play a major etiological role. Stabilization in the following birth cohorts suggests that the increase of mortality observed since 1980 may slow down in the near future.",
author = "Solen Kern{\'e}is and Pierre-Yves Bo{\"e}lle and {Freeman Grais}, Rebecca and G{\'e}rard Pavillon and Eric Jougla and Antoine Flahault and Lone Simonsen and Thomas Hanslik",
year = "2010",
language = "English",
volume = "25",
pages = "55--61",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer Netherlands",
number = "1",

}

Kernéis, S, Boëlle, P-Y, Freeman Grais, R, Pavillon, G, Jougla, E, Flahault, A, Simonsen, L & Hanslik, T 2010, 'Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis', European Journal of Epidemiology, bind 25, nr. 1, s. 55-61.

Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis. / Kernéis, Solen; Boëlle, Pierre-Yves; Freeman Grais, Rebecca; Pavillon, Gérard; Jougla, Eric; Flahault, Antoine; Simonsen, Lone; Hanslik, Thomas.

I: European Journal of Epidemiology, Bind 25, Nr. 1, 2010, s. 55-61.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis

AU - Kernéis, Solen

AU - Boëlle, Pierre-Yves

AU - Freeman Grais, Rebecca

AU - Pavillon, Gérard

AU - Jougla, Eric

AU - Flahault, Antoine

AU - Simonsen, Lone

AU - Hanslik, Thomas

PY - 2010

Y1 - 2010

N2 - We compared trends of Systemic Sclerosis (SS) mortality in France and the USA over the period 1980-1998 and used an Age-Period-Cohort (APC) model to adjust on the age at death of SS patients. All deaths coded with SS as an underlying primary or secondary cause in the national French and US mortality databases from 1980 to 1998 were included in the analysis. SS age-standardized mortality rates increased from 7.2 to 10.3/million in US women (+43%), and from 3 to 3.9/million in French women (+22%). Most of the increase occurred in senior women. In contrast, SS age-standardized death rates remained stable among US men (around 3/million) and French men (around 2/million). In US women, the APC analysis shows a growing cohort effect between 1900 and 1940, tending to stabilize for following cohorts. Similar findings were obtained to a lesser extent in French women. In conclusion, SS mortality rates increased by more than 40% between 1980 and 1998 in the USA, mostly in women born between 1900 and 1940. Whether these trends reflect rising incidence of SS need to be documented. The observed dissimilarity between genders and countries underline that environmental exposure and gender-related factors likely play a major etiological role. Stabilization in the following birth cohorts suggests that the increase of mortality observed since 1980 may slow down in the near future.

AB - We compared trends of Systemic Sclerosis (SS) mortality in France and the USA over the period 1980-1998 and used an Age-Period-Cohort (APC) model to adjust on the age at death of SS patients. All deaths coded with SS as an underlying primary or secondary cause in the national French and US mortality databases from 1980 to 1998 were included in the analysis. SS age-standardized mortality rates increased from 7.2 to 10.3/million in US women (+43%), and from 3 to 3.9/million in French women (+22%). Most of the increase occurred in senior women. In contrast, SS age-standardized death rates remained stable among US men (around 3/million) and French men (around 2/million). In US women, the APC analysis shows a growing cohort effect between 1900 and 1940, tending to stabilize for following cohorts. Similar findings were obtained to a lesser extent in French women. In conclusion, SS mortality rates increased by more than 40% between 1980 and 1998 in the USA, mostly in women born between 1900 and 1940. Whether these trends reflect rising incidence of SS need to be documented. The observed dissimilarity between genders and countries underline that environmental exposure and gender-related factors likely play a major etiological role. Stabilization in the following birth cohorts suggests that the increase of mortality observed since 1980 may slow down in the near future.

M3 - Journal article

VL - 25

SP - 55

EP - 61

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 1

ER -

Kernéis S, Boëlle P-Y, Freeman Grais R, Pavillon G, Jougla E, Flahault A et al. Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis. European Journal of Epidemiology. 2010;25(1):55-61.