Mortality patterns associated with the 1918 influenza pandemic in Mexico:

Evidence for a spring herald wave and lack of preexisting immunity in older populations

Gerardo Chowell, Cecile Viboud, Lone Simonsen, Mark Miller, R Acuna-Soto

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Although the mortality burden of the devastating 1918 influenza pandemic has been carefully quantified in the United States, Japan, and European countries, little is known about the pandemic experience elsewhere. Here, we compiled extensive archival records to quantify the pandemic mortality patterns in 2 Mexican cities, Mexico City and Toluca. METHODS: We applied seasonal excess mortality models to age-specific respiratory mortality rates for 1915-1920 and quantified the reproduction number from daily data. RESULTS: We identified 3 pandemic waves in Mexico City in spring 1918, autumn 1918, and winter 1920, which were characterized by unusual excess mortality among people 25-44 years old. Toluca experienced 2-fold higher excess mortality rates than Mexico City but did not experience a substantial third wave. All age groups, including that of people 65 years old, experienced excess mortality during 1918-1920. Reproduction number estimates were <2.5, assuming a 3-d generation interval. CONCLUSION: Mexico experienced a herald pandemic wave with elevated young adult mortality in spring 1918, similar to the United States and Europe. In contrast to the United States and Europe, there was no mortality sparing among Mexican seniors 65 years old, highlighting potential geographical differences in preexisting immunity to the 1918 virus. We discuss the relevance of our findings to the 2009 pandemic mortality patterns.
OriginalsprogEngelsk
TidsskriftJournal of Infectious Diseases
Vol/bind202
Udgave nummer4
Sider (fra-til)567-575
ISSN0022-1899
StatusUdgivet - 2010

Citer dette

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title = "Mortality patterns associated with the 1918 influenza pandemic in Mexico:: Evidence for a spring herald wave and lack of preexisting immunity in older populations",
abstract = "BACKGROUND: Although the mortality burden of the devastating 1918 influenza pandemic has been carefully quantified in the United States, Japan, and European countries, little is known about the pandemic experience elsewhere. Here, we compiled extensive archival records to quantify the pandemic mortality patterns in 2 Mexican cities, Mexico City and Toluca. METHODS: We applied seasonal excess mortality models to age-specific respiratory mortality rates for 1915-1920 and quantified the reproduction number from daily data. RESULTS: We identified 3 pandemic waves in Mexico City in spring 1918, autumn 1918, and winter 1920, which were characterized by unusual excess mortality among people 25-44 years old. Toluca experienced 2-fold higher excess mortality rates than Mexico City but did not experience a substantial third wave. All age groups, including that of people 65 years old, experienced excess mortality during 1918-1920. Reproduction number estimates were <2.5, assuming a 3-d generation interval. CONCLUSION: Mexico experienced a herald pandemic wave with elevated young adult mortality in spring 1918, similar to the United States and Europe. In contrast to the United States and Europe, there was no mortality sparing among Mexican seniors 65 years old, highlighting potential geographical differences in preexisting immunity to the 1918 virus. We discuss the relevance of our findings to the 2009 pandemic mortality patterns.",
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Mortality patterns associated with the 1918 influenza pandemic in Mexico: Evidence for a spring herald wave and lack of preexisting immunity in older populations. / Chowell, Gerardo; Viboud, Cecile; Simonsen, Lone; Miller, Mark; Acuna-Soto, R.

I: Journal of Infectious Diseases, Bind 202, Nr. 4, 2010, s. 567-575.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Mortality patterns associated with the 1918 influenza pandemic in Mexico:

T2 - Evidence for a spring herald wave and lack of preexisting immunity in older populations

AU - Chowell, Gerardo

AU - Viboud, Cecile

AU - Simonsen, Lone

AU - Miller, Mark

AU - Acuna-Soto, R

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Although the mortality burden of the devastating 1918 influenza pandemic has been carefully quantified in the United States, Japan, and European countries, little is known about the pandemic experience elsewhere. Here, we compiled extensive archival records to quantify the pandemic mortality patterns in 2 Mexican cities, Mexico City and Toluca. METHODS: We applied seasonal excess mortality models to age-specific respiratory mortality rates for 1915-1920 and quantified the reproduction number from daily data. RESULTS: We identified 3 pandemic waves in Mexico City in spring 1918, autumn 1918, and winter 1920, which were characterized by unusual excess mortality among people 25-44 years old. Toluca experienced 2-fold higher excess mortality rates than Mexico City but did not experience a substantial third wave. All age groups, including that of people 65 years old, experienced excess mortality during 1918-1920. Reproduction number estimates were <2.5, assuming a 3-d generation interval. CONCLUSION: Mexico experienced a herald pandemic wave with elevated young adult mortality in spring 1918, similar to the United States and Europe. In contrast to the United States and Europe, there was no mortality sparing among Mexican seniors 65 years old, highlighting potential geographical differences in preexisting immunity to the 1918 virus. We discuss the relevance of our findings to the 2009 pandemic mortality patterns.

AB - BACKGROUND: Although the mortality burden of the devastating 1918 influenza pandemic has been carefully quantified in the United States, Japan, and European countries, little is known about the pandemic experience elsewhere. Here, we compiled extensive archival records to quantify the pandemic mortality patterns in 2 Mexican cities, Mexico City and Toluca. METHODS: We applied seasonal excess mortality models to age-specific respiratory mortality rates for 1915-1920 and quantified the reproduction number from daily data. RESULTS: We identified 3 pandemic waves in Mexico City in spring 1918, autumn 1918, and winter 1920, which were characterized by unusual excess mortality among people 25-44 years old. Toluca experienced 2-fold higher excess mortality rates than Mexico City but did not experience a substantial third wave. All age groups, including that of people 65 years old, experienced excess mortality during 1918-1920. Reproduction number estimates were <2.5, assuming a 3-d generation interval. CONCLUSION: Mexico experienced a herald pandemic wave with elevated young adult mortality in spring 1918, similar to the United States and Europe. In contrast to the United States and Europe, there was no mortality sparing among Mexican seniors 65 years old, highlighting potential geographical differences in preexisting immunity to the 1918 virus. We discuss the relevance of our findings to the 2009 pandemic mortality patterns.

M3 - Journal article

VL - 202

SP - 567

EP - 575

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -