Montmorillonite and Laponite Clay Materials for the Solidification of Lipid-Based Formulations for the Basic Drug Blonanserin: In Vitro and in Vivo Investigations

Tahnee J. Dening, Nicky Thomas, Shasha Rao, Cis van Looveren, Filip Cuyckens, René Holm, Clive A. Prestidge

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Solid-state lipid-based formulations offer great potential for the improved oral delivery of poorly water-soluble drugs. This study investigates the use of the high-surface-area clay materials, montmorillonite and laponite, as solid carriers for lipid-based formulations. The unique cation-exchange properties of clay platelets were exploited to preload the ionizable hydrophobic compound, blonanserin, prior to encapsulating a drug-loaded lipid solution. Thus, solid-state lipid-based formulations with dual-loading capabilities were developed and studied. These formulations were compared with simple clay-based lipid formulations, where blonanserin was loaded in the lipid phase only. The drug release behavior of all clay-based formulations was assessed during in vitro dissolution studies under simulated gastric conditions and in vitro fasting intestinal lipolysis studies. Montmorillonite- and laponite-based lipid formulations significantly reduced blonanserin solubilization relative to a control lipid solution and silica–lipid hybrid particles, owing to incomplete drug release from the clay cation-exchange sites. This phenomenon was replicated during in vivo pharmacokinetic studies, whereby the bioavailability of simple clay-based lipid formulations was decreased relative to controls. Importantly, the solid-state dual-loaded montmorillonite-based lipid formulation provided an optimal pharmacokinetic performance, achieving the same degree of bioavailability enhancement as the control lipid solution. These findings indicate the potential of solid-state dual-loaded clay-based lipid formulations for increasing drug loading levels and enhancing the oral absorption of poorly soluble weak base compounds.
OriginalsprogEngelsk
TidsskriftMolecular Pharmaceutics
Vol/bind15
Udgave nummer9
Sider (fra-til)4148–4160
ISSN1543-8384
DOI
StatusUdgivet - 2018

Emneord

  • Bentonite
  • Bioavalability
  • Blonanserin
  • Cation exchange
  • Laponite
  • lipid-based formulation
  • Monmorillonite
  • Oral
  • Poorly water-soluble drug
  • Smectite

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