Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe

Jaime Brizuela; Thomas J. Roodsant; Qureisha Hasnoe; Boas C.L. van der Putten; Jana Kozakova; Hans Christian Slotved; Mark van der Linden; Ilse G.A. de Beer-Schuurman; Ewa Sadowy; Juan Antonio Sáez-Nieto; Victoria J. Chalker; Kees C.H. van der Ark; Constance Schultsz

doi:10.3201/eid3003.230348

Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe

Jaime Brizuela^*, Thomas J. Roodsant, Qureisha Hasnoe, Boas C.L. van der Putten, Jana Kozakova, Hans Christian Slotved, Mark van der Linden, Ilse G.A. de Beer-Schuurman, Ewa Sadowy, Juan Antonio Sáez-Nieto, Victoria J. Chalker, Kees C.H. van der Ark, Constance Schultsz

^*Corresponding author

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Streptococcus suis, a zoonotic bacterial pathogen circulated through swine, can cause severe infections in humans. Because human S. suis infections are not notifiable in most countries, incidence is underestimated. We aimed to increase insight into the molecular epidemiology of human S. suis infections in Europe. To procure data, we surveyed 7 reference laboratories and performed a systematic review of the scientific literature. We identified 236 cases of human S. suis infection from those sources and an additional 87 by scanning gray literature. We performed whole-genome sequencing to type 46 zoonotic S. suis isolates and combined them with 28 publicly available genomes in a core-genome phylogeny. Clonal complex (CC) 1 isolates accounted for 87% of typed human infections; CC20, CC25, CC87, and CC94 also caused infections. Emergence of diverse zoonotic clades and notable severity of illness in humans support classifying S. suis infection as a notifiable condition.

Originalsprog	Engelsk
Tidsskrift	Emerging Infectious Diseases
Vol/bind	30
Udgave nummer	3
Sider (fra-til)	413-422
Antal sider	10
ISSN	1080-6040
DOI	https://doi.org/10.3201/eid3003.230348
Status	Udgivet - mar. 2024
Udgivet eksternt	Ja

Bibliografisk note

Publisher Copyright:
© 2024 Centers for Disease Control and Prevention (CDC). All rights reserved.

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10.3201/eid3003.230348

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Brizuela, J., Roodsant, T. J., Hasnoe, Q., van der Putten, B. C. L., Kozakova, J., Slotved, H. C., van der Linden, M., de Beer-Schuurman, I. G. A., Sadowy, E., Sáez-Nieto, J. A., Chalker, V. J., van der Ark, K. C. H., & Schultsz, C. (2024). Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe. Emerging Infectious Diseases , 30(3), 413-422. https://doi.org/10.3201/eid3003.230348

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title = "Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe",

abstract = "Streptococcus suis, a zoonotic bacterial pathogen circulated through swine, can cause severe infections in humans. Because human S. suis infections are not notifiable in most countries, incidence is underestimated. We aimed to increase insight into the molecular epidemiology of human S. suis infections in Europe. To procure data, we surveyed 7 reference laboratories and performed a systematic review of the scientific literature. We identified 236 cases of human S. suis infection from those sources and an additional 87 by scanning gray literature. We performed whole-genome sequencing to type 46 zoonotic S. suis isolates and combined them with 28 publicly available genomes in a core-genome phylogeny. Clonal complex (CC) 1 isolates accounted for 87% of typed human infections; CC20, CC25, CC87, and CC94 also caused infections. Emergence of diverse zoonotic clades and notable severity of illness in humans support classifying S. suis infection as a notifiable condition.",

author = "Jaime Brizuela and Roodsant, {Thomas J.} and Qureisha Hasnoe and {van der Putten}, {Boas C.L.} and Jana Kozakova and Slotved, {Hans Christian} and {van der Linden}, Mark and {de Beer-Schuurman}, {Ilse G.A.} and Ewa Sadowy and S{\'a}ez-Nieto, {Juan Antonio} and Chalker, {Victoria J.} and {van der Ark}, {Kees C.H.} and Constance Schultsz",

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doi = "10.3201/eid3003.230348",

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Brizuela, J, Roodsant, TJ, Hasnoe, Q, van der Putten, BCL, Kozakova, J, Slotved, HC, van der Linden, M, de Beer-Schuurman, IGA, Sadowy, E, Sáez-Nieto, JA, Chalker, VJ, van der Ark, KCH & Schultsz, C 2024, 'Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe', Emerging Infectious Diseases , bind 30, nr. 3, s. 413-422. https://doi.org/10.3201/eid3003.230348

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AU - Brizuela, Jaime

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AU - Hasnoe, Qureisha

AU - van der Putten, Boas C.L.

AU - Kozakova, Jana

AU - Slotved, Hans Christian

AU - van der Linden, Mark

AU - de Beer-Schuurman, Ilse G.A.

AU - Sadowy, Ewa

AU - Sáez-Nieto, Juan Antonio

AU - Chalker, Victoria J.

AU - van der Ark, Kees C.H.

AU - Schultsz, Constance

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