@inbook{1a4da5a8c71641b3905e41ec19938a47,
title = "Molecular biology of Escherichia coli type 1 fimbriae",
abstract = "Most strains of Escherichia coli are able to express type 1 fimbriae. These are thread-like surface organelles consisting of around 1000 subunits of a major structural component, the FimA protein, as well as a few percent minor components. Type 1 fimbriae mediate binding to D-mannose containing structures and thereby enable the bacteria to colonize various host tissues (1, 2). Inhibition of binding of type 1 fimbriated bacteria as well as purified type 1 fimbriae to various cell types has been extensively studied. In all cases it was found that D-mannose itself and most derivatives of this sugar were very potent inhibitors of type 1 fimbriae mediated adhesion, whereas all saccharides not containing D-mannose showed no inhibitory effect. It has been proposed that the biological role of type 1 fimbriae is to provide bacterial adhesion to mucus in the large intestine which is the natural habitat of E. coli. Furthermore, several lines of evidence point to a role of type 1 fimbriae as possible virulence factors in uropathogenic E. coli strains.",
author = "Per Klemm and Krogfelt, {Karen A}",
year = "1991",
doi = "10.1007/978-1-4684-5982-1_12",
language = "Udefineret/Ukendt",
isbn = "978-1-4684-5984-5",
series = "F.E.M.S. Symposium Series",
pages = "87--92",
editor = "T Wadstr{\"o}m and PH M{\"a}kel{\"a} and A.-M. Svennerholm and H. Wolf-Watz",
booktitle = "Molecular Pathogenesis of Gastrointestinal Infections",
publisher = "Springer",
}