Mitogen activated protein kinases: A role in inflammatory bowel disease?

O. J. Broom, B. Widjaya, J. Troelsen, J. Olsen, O. H. Nielsen

Publikation: Bidrag til tidsskriftReviewpeer review

Abstract

Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.
OriginalsprogEngelsk
TidsskriftClinical and Experimental Immunology
Vol/bind158
Udgave nummer3
Sider (fra-til)272-280
Antal sider9
ISSN0009-9104
DOI
StatusUdgivet - dec. 2009
Udgivet eksterntJa

Emneord

  • Inflammation
  • Inflammatory bowel disease
  • MAP kinase

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