Mild heat treatments induce long-term changes in metabolites associated with energy metabolism in Drosophila melanogaster

Pernille Sarup, Simon Metz Mariendal Petersen, Niels Chr Nielsen, Volker Loeschcke, Anders Malmendal

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Heat-induced hormesis, the beneficial effect of mild heat-induced stress, increases the average lifespan of many organisms. Yet little is known about the mechanisms underlying this effect. We used nuclear magnetic resonance spectroscopy to investigate the long-term effects of repeated mild heat treatments on the metabolome of male Drosophila melanogaster. 10 days after the heat treatment, metabolic aging appears to be slowed down, and a treatment response with 40 % higher levels of alanine and lactate and lower levels of aspartate and glutamate were measured. All treatment effects had disappeared 16 days later. Metabolic reprogramming has been associated with the life extending effects of dietary restriction. The metabolite changes induced by the hormetic treatment suggest that the positive effects might not be limited to the repair pathways induced, but that there also is a change in energy metabolism. A possible direct link between changes in energy metabolism and heat induced increase in Hsp70 expression is discussed.

OriginalsprogEngelsk
TidsskriftBiogerontology
Vol/bind17
Udgave nummer5
Sider (fra-til)873-882
Antal sider10
ISSN1389-5729
DOI
StatusUdgivet - nov. 2016
Udgivet eksterntJa

Citer dette

Sarup, Pernille ; Petersen, Simon Metz Mariendal ; Nielsen, Niels Chr ; Loeschcke, Volker ; Malmendal, Anders. / Mild heat treatments induce long-term changes in metabolites associated with energy metabolism in Drosophila melanogaster. I: Biogerontology. 2016 ; Bind 17, Nr. 5. s. 873-882.
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abstract = "Heat-induced hormesis, the beneficial effect of mild heat-induced stress, increases the average lifespan of many organisms. Yet little is known about the mechanisms underlying this effect. We used nuclear magnetic resonance spectroscopy to investigate the long-term effects of repeated mild heat treatments on the metabolome of male Drosophila melanogaster. 10 days after the heat treatment, metabolic aging appears to be slowed down, and a treatment response with 40 {\%} higher levels of alanine and lactate and lower levels of aspartate and glutamate were measured. All treatment effects had disappeared 16 days later. Metabolic reprogramming has been associated with the life extending effects of dietary restriction. The metabolite changes induced by the hormetic treatment suggest that the positive effects might not be limited to the repair pathways induced, but that there also is a change in energy metabolism. A possible direct link between changes in energy metabolism and heat induced increase in Hsp70 expression is discussed.",
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Mild heat treatments induce long-term changes in metabolites associated with energy metabolism in Drosophila melanogaster. / Sarup, Pernille; Petersen, Simon Metz Mariendal; Nielsen, Niels Chr; Loeschcke, Volker; Malmendal, Anders.

I: Biogerontology, Bind 17, Nr. 5, 11.2016, s. 873-882.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Mild heat treatments induce long-term changes in metabolites associated with energy metabolism in Drosophila melanogaster

AU - Sarup, Pernille

AU - Petersen, Simon Metz Mariendal

AU - Nielsen, Niels Chr

AU - Loeschcke, Volker

AU - Malmendal, Anders

PY - 2016/11

Y1 - 2016/11

N2 - Heat-induced hormesis, the beneficial effect of mild heat-induced stress, increases the average lifespan of many organisms. Yet little is known about the mechanisms underlying this effect. We used nuclear magnetic resonance spectroscopy to investigate the long-term effects of repeated mild heat treatments on the metabolome of male Drosophila melanogaster. 10 days after the heat treatment, metabolic aging appears to be slowed down, and a treatment response with 40 % higher levels of alanine and lactate and lower levels of aspartate and glutamate were measured. All treatment effects had disappeared 16 days later. Metabolic reprogramming has been associated with the life extending effects of dietary restriction. The metabolite changes induced by the hormetic treatment suggest that the positive effects might not be limited to the repair pathways induced, but that there also is a change in energy metabolism. A possible direct link between changes in energy metabolism and heat induced increase in Hsp70 expression is discussed.

AB - Heat-induced hormesis, the beneficial effect of mild heat-induced stress, increases the average lifespan of many organisms. Yet little is known about the mechanisms underlying this effect. We used nuclear magnetic resonance spectroscopy to investigate the long-term effects of repeated mild heat treatments on the metabolome of male Drosophila melanogaster. 10 days after the heat treatment, metabolic aging appears to be slowed down, and a treatment response with 40 % higher levels of alanine and lactate and lower levels of aspartate and glutamate were measured. All treatment effects had disappeared 16 days later. Metabolic reprogramming has been associated with the life extending effects of dietary restriction. The metabolite changes induced by the hormetic treatment suggest that the positive effects might not be limited to the repair pathways induced, but that there also is a change in energy metabolism. A possible direct link between changes in energy metabolism and heat induced increase in Hsp70 expression is discussed.

U2 - 10.1007/s10522-016-9657-5

DO - 10.1007/s10522-016-9657-5

M3 - Journal article

VL - 17

SP - 873

EP - 882

JO - Biogerontology

JF - Biogerontology

SN - 1389-5729

IS - 5

ER -