MicroRNAs Related to Polycystic Ovary Syndrome (PCOS)

Anja Elaine Sørensen, Marie Louise Muff Wissing, Sofia Salö, Anne Lis Mikkelsen Englund, Louise Torp Dalgaard

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Polycystic ovary syndrome (PCOS) is the most common, though heterogeneous, endocrine aberration in women of reproductive age, with high prevalence and socioeconomic costs. The syndrome is characterized by polycystic ovaries, chronic anovulation and hyperandrogenism, as well as being associated with infertility, insulin resistance, chronic low-grade inflammation and an increased life time risk of type 2 diabetes. MicroRNAs (miRNAs) are small, non-coding RNAs that are able to regulate gene expression at the post-transcriptional level. Altered miRNA levels have been associated with diabetes, insulin resistance, inflammation and various cancers. Studies have shown that circulating miRNAs are present in whole blood, serum, plasma and the follicular fluid of PCOS patients and that they might serve as potential biomarkers and a new approach for the diagnosis of PCOS. In this review, recent work on miRNAs with respect to PCOS will be summarized. Our understanding of miRNAs, particularly in relation to PCOS, is currently at a very early stage, and additional studies will yield important insight into the molecular mechanisms behind this complex and heterogenic syndrome
    OriginalsprogEngelsk
    Artikelnummerdoi: 10.3390/genes5030684
    TidsskriftGenes
    Vol/bind5
    Udgave nummer3
    Sider (fra-til)684-708
    Antal sider24
    ISSN2073-4425
    DOI
    StatusUdgivet - 7 aug. 2014

    Emneord

    • microRNA
    • poly-cystic ovary syndrome
    • insulin resistance

    Citer dette

    Sørensen, A. E., Wissing, M. L. M., Salö, S., Englund, A. L. M., & Dalgaard, L. T. (2014). MicroRNAs Related to Polycystic Ovary Syndrome (PCOS). Genes, 5(3), 684-708. [doi: 10.3390/genes5030684]. https://doi.org/10.3390/genes5030684
    Sørensen, Anja Elaine ; Wissing, Marie Louise Muff ; Salö, Sofia ; Englund, Anne Lis Mikkelsen ; Dalgaard, Louise Torp. / MicroRNAs Related to Polycystic Ovary Syndrome (PCOS). I: Genes. 2014 ; Bind 5, Nr. 3. s. 684-708.
    @article{3430b35e905445deb64aff61001897a5,
    title = "MicroRNAs Related to Polycystic Ovary Syndrome (PCOS)",
    abstract = "Polycystic ovary syndrome (PCOS) is the most common, though heterogeneous, endocrine aberration in women of reproductive age, with high prevalence and socioeconomic costs. The syndrome is characterized by polycystic ovaries, chronic anovulation and hyperandrogenism, as well as being associated with infertility, insulin resistance, chronic low-grade inflammation and an increased life time risk of type 2 diabetes. MicroRNAs (miRNAs) are small, non-coding RNAs that are able to regulate gene expression at the post-transcriptional level. Altered miRNA levels have been associated with diabetes, insulin resistance, inflammation and various cancers. Studies have shown that circulating miRNAs are present in whole blood, serum, plasma and the follicular fluid of PCOS patients and that they might serve as potential biomarkers and a new approach for the diagnosis of PCOS. In this review, recent work on miRNAs with respect to PCOS will be summarized. Our understanding of miRNAs, particularly in relation to PCOS, is currently at a very early stage, and additional studies will yield important insight into the molecular mechanisms behind this complex and heterogenic syndrome",
    keywords = "microRNA, poly-cystic ovary syndrome, insulin resistance, microRNA, poly-cystic ovary syndrome, insulin resistance",
    author = "S{\o}rensen, {Anja Elaine} and Wissing, {Marie Louise Muff} and Sofia Sal{\"o} and Englund, {Anne Lis Mikkelsen} and Dalgaard, {Louise Torp}",
    year = "2014",
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    doi = "10.3390/genes5030684",
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    Sørensen, AE, Wissing, MLM, Salö, S, Englund, ALM & Dalgaard, LT 2014, 'MicroRNAs Related to Polycystic Ovary Syndrome (PCOS)', Genes, bind 5, nr. 3, doi: 10.3390/genes5030684, s. 684-708. https://doi.org/10.3390/genes5030684

    MicroRNAs Related to Polycystic Ovary Syndrome (PCOS). / Sørensen, Anja Elaine; Wissing, Marie Louise Muff; Salö, Sofia; Englund, Anne Lis Mikkelsen; Dalgaard, Louise Torp.

    I: Genes, Bind 5, Nr. 3, doi: 10.3390/genes5030684, 07.08.2014, s. 684-708.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - MicroRNAs Related to Polycystic Ovary Syndrome (PCOS)

    AU - Sørensen, Anja Elaine

    AU - Wissing, Marie Louise Muff

    AU - Salö, Sofia

    AU - Englund, Anne Lis Mikkelsen

    AU - Dalgaard, Louise Torp

    PY - 2014/8/7

    Y1 - 2014/8/7

    N2 - Polycystic ovary syndrome (PCOS) is the most common, though heterogeneous, endocrine aberration in women of reproductive age, with high prevalence and socioeconomic costs. The syndrome is characterized by polycystic ovaries, chronic anovulation and hyperandrogenism, as well as being associated with infertility, insulin resistance, chronic low-grade inflammation and an increased life time risk of type 2 diabetes. MicroRNAs (miRNAs) are small, non-coding RNAs that are able to regulate gene expression at the post-transcriptional level. Altered miRNA levels have been associated with diabetes, insulin resistance, inflammation and various cancers. Studies have shown that circulating miRNAs are present in whole blood, serum, plasma and the follicular fluid of PCOS patients and that they might serve as potential biomarkers and a new approach for the diagnosis of PCOS. In this review, recent work on miRNAs with respect to PCOS will be summarized. Our understanding of miRNAs, particularly in relation to PCOS, is currently at a very early stage, and additional studies will yield important insight into the molecular mechanisms behind this complex and heterogenic syndrome

    AB - Polycystic ovary syndrome (PCOS) is the most common, though heterogeneous, endocrine aberration in women of reproductive age, with high prevalence and socioeconomic costs. The syndrome is characterized by polycystic ovaries, chronic anovulation and hyperandrogenism, as well as being associated with infertility, insulin resistance, chronic low-grade inflammation and an increased life time risk of type 2 diabetes. MicroRNAs (miRNAs) are small, non-coding RNAs that are able to regulate gene expression at the post-transcriptional level. Altered miRNA levels have been associated with diabetes, insulin resistance, inflammation and various cancers. Studies have shown that circulating miRNAs are present in whole blood, serum, plasma and the follicular fluid of PCOS patients and that they might serve as potential biomarkers and a new approach for the diagnosis of PCOS. In this review, recent work on miRNAs with respect to PCOS will be summarized. Our understanding of miRNAs, particularly in relation to PCOS, is currently at a very early stage, and additional studies will yield important insight into the molecular mechanisms behind this complex and heterogenic syndrome

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    KW - insulin resistance

    KW - microRNA

    KW - poly-cystic ovary syndrome

    KW - insulin resistance

    U2 - 10.3390/genes5030684

    DO - 10.3390/genes5030684

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    JO - Genes

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    Sørensen AE, Wissing MLM, Salö S, Englund ALM, Dalgaard LT. MicroRNAs Related to Polycystic Ovary Syndrome (PCOS). Genes. 2014 aug 7;5(3):684-708. doi: 10.3390/genes5030684. https://doi.org/10.3390/genes5030684