MicroRNAs Related to Polycystic Ovary Syndrome (PCOS)

Anja Elaine Sørensen, Marie Louise Muff Wissing, Sofia Salö, Anne Lis Mikkelsen Englund, Louise Torp Dalgaard

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Abstract

    Polycystic ovary syndrome (PCOS) is the most common, though heterogeneous, endocrine aberration in women of reproductive age, with high prevalence and socioeconomic costs. The syndrome is characterized by polycystic ovaries, chronic anovulation and hyperandrogenism, as well as being associated with infertility, insulin resistance, chronic low-grade inflammation and an increased life time risk of type 2 diabetes. MicroRNAs (miRNAs) are small, non-coding RNAs that are able to regulate gene expression at the post-transcriptional level. Altered miRNA levels have been associated with diabetes, insulin resistance, inflammation and various cancers. Studies have shown that circulating miRNAs are present in whole blood, serum, plasma and the follicular fluid of PCOS patients and that they might serve as potential biomarkers and a new approach for the diagnosis of PCOS. In this review, recent work on miRNAs with respect to PCOS will be summarized. Our understanding of miRNAs, particularly in relation to PCOS, is currently at a very early stage, and additional studies will yield important insight into the molecular mechanisms behind this complex and heterogenic syndrome
    OriginalsprogEngelsk
    Artikelnummerdoi: 10.3390/genes5030684
    TidsskriftGenes
    Vol/bind5
    Udgave nummer3
    Sider (fra-til)684-708
    Antal sider24
    ISSN2073-4425
    DOI
    StatusUdgivet - 7 aug. 2014

    Emneord

    • microRNA
    • poly-cystic ovary syndrome
    • insulin resistance

    Citer dette

    Sørensen, A. E., Wissing, M. L. M., Salö, S., Englund, A. L. M., & Dalgaard, L. T. (2014). MicroRNAs Related to Polycystic Ovary Syndrome (PCOS). Genes, 5(3), 684-708. [doi: 10.3390/genes5030684]. https://doi.org/10.3390/genes5030684