Macrocyclic fragrance materials

A screening-level environmental assessment using chemical categorization

Daniel Salvito, Aurelia Lapczynski, Christen Sachse-Vasquez, Colin McIntosh, Peter Calow, Helmut Greim, Beate Escher

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    A screening-level aquatic environmental risk assessment for macrocyclic fragrance materials using a “group approach” is presented using data for 30 macrocyclic fragrance ingredients. In this group approach, conservative estimates of environmental exposure and ecotoxicological effects thresholds for compounds within two subgroups (15 macrocyclic ketones and 15 macrocyclic lactones/lactides) were used to estimate the aquatic ecological risk potential for these subgroups. It is reasonable to separate these fragrance materials into the two subgroups based on the likely metabolic pathway required for biodegradation and on expected different ecotoxicological modes of action. The current volumes of use for the macrocyclic ketones in both Europe and North America ranges from <1 (low kg quantities) to no greater than 50 metric tonnes in either region and for macrocyclic lactones/lactides the volume of use range for both regions is <1 to no greater than 1000 metric tonnes in any one region. Based on these regional tonnages, biodegradability of these two subgroups of materials, and minimal in stream dilution (3:1), the conservatively predicted exposure concentrations for macrocyclic ketones would range from <0.01 to 0.05 μg/L in Europe and from <0.01 to 0.03 μg/L in North America. For macrocyclic lactones/lactides, the concentration within the mixing zone would range from <0.01 to 0.7 μg/L in Europe and from <0.01 to 1.0 μg/L in North America. The PNECs derived for the macrocyclic ketones is 0.22 μg/L and for macrocyclic lactones/lactides is 2.7 μg/L. The results of this screening-level aquatic ecological risk assessment indicate that at their current tonnage, often referred to as volumes of use, macrocyclic fragrance materials in Europe and North America, pose a negligible risk to aquatic biota; with no PEC/PNEC ratio exceeding 1 for any material in any subgroup.
    OriginalsprogEngelsk
    TidsskriftEcotoxicology and Environmental Safety
    Vol/bind74
    Udgave nummer6
    Sider (fra-til)1619-1629
    ISSN0147-6513
    DOI
    StatusUdgivet - 2011

    Emneord

    • Risk assessment
    • Chemical categorization
    • Fragrance ingredients

    Citer dette

    Salvito, D., Lapczynski, A., Sachse-Vasquez, C., McIntosh, C., Calow, P., Greim, H., & Escher, B. (2011). Macrocyclic fragrance materials: A screening-level environmental assessment using chemical categorization. Ecotoxicology and Environmental Safety, 74(6), 1619-1629. https://doi.org/10.1016/j.ecoenv.2011.05.002
    Salvito, Daniel ; Lapczynski, Aurelia ; Sachse-Vasquez, Christen ; McIntosh, Colin ; Calow, Peter ; Greim, Helmut ; Escher, Beate. / Macrocyclic fragrance materials : A screening-level environmental assessment using chemical categorization. I: Ecotoxicology and Environmental Safety. 2011 ; Bind 74, Nr. 6. s. 1619-1629.
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    abstract = "A screening-level aquatic environmental risk assessment for macrocyclic fragrance materials using a “group approach” is presented using data for 30 macrocyclic fragrance ingredients. In this group approach, conservative estimates of environmental exposure and ecotoxicological effects thresholds for compounds within two subgroups (15 macrocyclic ketones and 15 macrocyclic lactones/lactides) were used to estimate the aquatic ecological risk potential for these subgroups. It is reasonable to separate these fragrance materials into the two subgroups based on the likely metabolic pathway required for biodegradation and on expected different ecotoxicological modes of action. The current volumes of use for the macrocyclic ketones in both Europe and North America ranges from <1 (low kg quantities) to no greater than 50 metric tonnes in either region and for macrocyclic lactones/lactides the volume of use range for both regions is <1 to no greater than 1000 metric tonnes in any one region. Based on these regional tonnages, biodegradability of these two subgroups of materials, and minimal in stream dilution (3:1), the conservatively predicted exposure concentrations for macrocyclic ketones would range from <0.01 to 0.05 μg/L in Europe and from <0.01 to 0.03 μg/L in North America. For macrocyclic lactones/lactides, the concentration within the mixing zone would range from <0.01 to 0.7 μg/L in Europe and from <0.01 to 1.0 μg/L in North America. The PNECs derived for the macrocyclic ketones is 0.22 μg/L and for macrocyclic lactones/lactides is 2.7 μg/L. The results of this screening-level aquatic ecological risk assessment indicate that at their current tonnage, often referred to as volumes of use, macrocyclic fragrance materials in Europe and North America, pose a negligible risk to aquatic biota; with no PEC/PNEC ratio exceeding 1 for any material in any subgroup.",
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    Salvito, D, Lapczynski, A, Sachse-Vasquez, C, McIntosh, C, Calow, P, Greim, H & Escher, B 2011, 'Macrocyclic fragrance materials: A screening-level environmental assessment using chemical categorization', Ecotoxicology and Environmental Safety, bind 74, nr. 6, s. 1619-1629. https://doi.org/10.1016/j.ecoenv.2011.05.002

    Macrocyclic fragrance materials : A screening-level environmental assessment using chemical categorization. / Salvito, Daniel; Lapczynski, Aurelia; Sachse-Vasquez, Christen; McIntosh, Colin; Calow, Peter; Greim, Helmut; Escher, Beate.

    I: Ecotoxicology and Environmental Safety, Bind 74, Nr. 6, 2011, s. 1619-1629.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Macrocyclic fragrance materials

    T2 - A screening-level environmental assessment using chemical categorization

    AU - Salvito, Daniel

    AU - Lapczynski, Aurelia

    AU - Sachse-Vasquez, Christen

    AU - McIntosh, Colin

    AU - Calow, Peter

    AU - Greim, Helmut

    AU - Escher, Beate

    PY - 2011

    Y1 - 2011

    N2 - A screening-level aquatic environmental risk assessment for macrocyclic fragrance materials using a “group approach” is presented using data for 30 macrocyclic fragrance ingredients. In this group approach, conservative estimates of environmental exposure and ecotoxicological effects thresholds for compounds within two subgroups (15 macrocyclic ketones and 15 macrocyclic lactones/lactides) were used to estimate the aquatic ecological risk potential for these subgroups. It is reasonable to separate these fragrance materials into the two subgroups based on the likely metabolic pathway required for biodegradation and on expected different ecotoxicological modes of action. The current volumes of use for the macrocyclic ketones in both Europe and North America ranges from <1 (low kg quantities) to no greater than 50 metric tonnes in either region and for macrocyclic lactones/lactides the volume of use range for both regions is <1 to no greater than 1000 metric tonnes in any one region. Based on these regional tonnages, biodegradability of these two subgroups of materials, and minimal in stream dilution (3:1), the conservatively predicted exposure concentrations for macrocyclic ketones would range from <0.01 to 0.05 μg/L in Europe and from <0.01 to 0.03 μg/L in North America. For macrocyclic lactones/lactides, the concentration within the mixing zone would range from <0.01 to 0.7 μg/L in Europe and from <0.01 to 1.0 μg/L in North America. The PNECs derived for the macrocyclic ketones is 0.22 μg/L and for macrocyclic lactones/lactides is 2.7 μg/L. The results of this screening-level aquatic ecological risk assessment indicate that at their current tonnage, often referred to as volumes of use, macrocyclic fragrance materials in Europe and North America, pose a negligible risk to aquatic biota; with no PEC/PNEC ratio exceeding 1 for any material in any subgroup.

    AB - A screening-level aquatic environmental risk assessment for macrocyclic fragrance materials using a “group approach” is presented using data for 30 macrocyclic fragrance ingredients. In this group approach, conservative estimates of environmental exposure and ecotoxicological effects thresholds for compounds within two subgroups (15 macrocyclic ketones and 15 macrocyclic lactones/lactides) were used to estimate the aquatic ecological risk potential for these subgroups. It is reasonable to separate these fragrance materials into the two subgroups based on the likely metabolic pathway required for biodegradation and on expected different ecotoxicological modes of action. The current volumes of use for the macrocyclic ketones in both Europe and North America ranges from <1 (low kg quantities) to no greater than 50 metric tonnes in either region and for macrocyclic lactones/lactides the volume of use range for both regions is <1 to no greater than 1000 metric tonnes in any one region. Based on these regional tonnages, biodegradability of these two subgroups of materials, and minimal in stream dilution (3:1), the conservatively predicted exposure concentrations for macrocyclic ketones would range from <0.01 to 0.05 μg/L in Europe and from <0.01 to 0.03 μg/L in North America. For macrocyclic lactones/lactides, the concentration within the mixing zone would range from <0.01 to 0.7 μg/L in Europe and from <0.01 to 1.0 μg/L in North America. The PNECs derived for the macrocyclic ketones is 0.22 μg/L and for macrocyclic lactones/lactides is 2.7 μg/L. The results of this screening-level aquatic ecological risk assessment indicate that at their current tonnage, often referred to as volumes of use, macrocyclic fragrance materials in Europe and North America, pose a negligible risk to aquatic biota; with no PEC/PNEC ratio exceeding 1 for any material in any subgroup.

    KW - Risk assessment

    KW - Chemical categorization

    KW - Fragrance ingredients

    U2 - 10.1016/j.ecoenv.2011.05.002

    DO - 10.1016/j.ecoenv.2011.05.002

    M3 - Journal article

    VL - 74

    SP - 1619

    EP - 1629

    JO - Ecotoxicology and Environmental Safety

    JF - Ecotoxicology and Environmental Safety

    SN - 0147-6513

    IS - 6

    ER -