Long-term residential exposure to air pollution and Hodgkin lymphoma risk among adults in Denmark: a population-based case–control study

Tahir Taj*, Aslak Harbo Poulsen, Matthias Ketzel, Camilla Geels, Jørgen Brandt, Jesper Heile Christensen, Ulla Arthur Hvidtfeldt, Mette Sørensen, Ole Raaschou-Nielsen

*Corresponding author

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Purpose: The etiology of Hodgkin lymphoma (HL) is obscure. Research on air pollution and risk of HL provides inconsistent results. We aimed to investigate the association between long-term residential exposure to air pollution and risk of adult Hodgkin lymphoma in Denmark. Methods: We performed a nationwide register-based case–control study, including all (n = 2,681) Hodgkin lymphoma cases registered in the nationwide Danish Cancer Registry between 1989 and 2014. We randomly selected 8,853 age- and sex-matched controls from the entire Danish population using the Civil Registration System, and identified 20-year residential address history for all cases and controls. We modeled outdoor air pollution concentrations at all these addresses using the high-resolution multiscale air pollution model system DEHM/UBM/AirGIS. We used conditional logistic regression to estimate odds ratios adjusted for individual and neighborhood level sociodemographic variables. Results: There was no association between 1, 5, 10, and 20 years’ time-weighted average exposure to fine particles (PM2.5), O3, SO2, NO2, or the PM2.5 constituents OC, NH4, NO3, and SO4 and risk of Hodgkin lymphoma. Conclusion: Residential exposure to ambient air pollution does not seem to increase the risk of developing Hodgkin lymphoma.

TidsskriftCancer Causes and Control
Udgave nummer9
Sider (fra-til)935-942
Antal sider8
StatusUdgivet - sep. 2021

Bibliografisk note

Funding Information:
The research was funded by Nordforsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir—Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries).G.


  • Air pollution
  • Case–control
  • Hodgkin lymphoma
  • Long-term exposure

Citer dette