TY - JOUR
T1 - Long-term residential exposure to air pollution and Hodgkin lymphoma risk among adults in Denmark
T2 - a population-based case–control study
AU - Taj, Tahir
AU - Poulsen, Aslak Harbo
AU - Ketzel, Matthias
AU - Geels, Camilla
AU - Brandt, Jørgen
AU - Christensen, Jesper Heile
AU - Hvidtfeldt, Ulla Arthur
AU - Sørensen, Mette
AU - Raaschou-Nielsen, Ole
PY - 2021/9
Y1 - 2021/9
N2 - Purpose: The etiology of Hodgkin lymphoma (HL) is obscure. Research on air pollution and risk of HL provides inconsistent results. We aimed to investigate the association between long-term residential exposure to air pollution and risk of adult Hodgkin lymphoma in Denmark. Methods: We performed a nationwide register-based case–control study, including all (n = 2,681) Hodgkin lymphoma cases registered in the nationwide Danish Cancer Registry between 1989 and 2014. We randomly selected 8,853 age- and sex-matched controls from the entire Danish population using the Civil Registration System, and identified 20-year residential address history for all cases and controls. We modeled outdoor air pollution concentrations at all these addresses using the high-resolution multiscale air pollution model system DEHM/UBM/AirGIS. We used conditional logistic regression to estimate odds ratios adjusted for individual and neighborhood level sociodemographic variables. Results: There was no association between 1, 5, 10, and 20 years’ time-weighted average exposure to fine particles (PM2.5), O3, SO2, NO2, or the PM2.5 constituents OC, NH4, NO3, and SO4 and risk of Hodgkin lymphoma. Conclusion: Residential exposure to ambient air pollution does not seem to increase the risk of developing Hodgkin lymphoma.
AB - Purpose: The etiology of Hodgkin lymphoma (HL) is obscure. Research on air pollution and risk of HL provides inconsistent results. We aimed to investigate the association between long-term residential exposure to air pollution and risk of adult Hodgkin lymphoma in Denmark. Methods: We performed a nationwide register-based case–control study, including all (n = 2,681) Hodgkin lymphoma cases registered in the nationwide Danish Cancer Registry between 1989 and 2014. We randomly selected 8,853 age- and sex-matched controls from the entire Danish population using the Civil Registration System, and identified 20-year residential address history for all cases and controls. We modeled outdoor air pollution concentrations at all these addresses using the high-resolution multiscale air pollution model system DEHM/UBM/AirGIS. We used conditional logistic regression to estimate odds ratios adjusted for individual and neighborhood level sociodemographic variables. Results: There was no association between 1, 5, 10, and 20 years’ time-weighted average exposure to fine particles (PM2.5), O3, SO2, NO2, or the PM2.5 constituents OC, NH4, NO3, and SO4 and risk of Hodgkin lymphoma. Conclusion: Residential exposure to ambient air pollution does not seem to increase the risk of developing Hodgkin lymphoma.
KW - Air pollution
KW - Case–control
KW - Hodgkin lymphoma
KW - Long-term exposure
KW - Air pollution
KW - Case–control
KW - Hodgkin lymphoma
KW - Long-term exposure
U2 - 10.1007/s10552-021-01446-w
DO - 10.1007/s10552-021-01446-w
M3 - Journal article
C2 - 34050843
AN - SCOPUS:85107025944
SN - 0957-5243
VL - 32
SP - 935
EP - 942
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 9
ER -