Long-term follow-up of the TIPS early detection in psychosis study

effects on 10-year outcome

Erik Simonsen, Wenche ten Welden Hegelstad, Tor Ketil Larsen, B Auestad, Julie Evensen, Ulrik Helt Haahr, Inge Joa, Jan Olav Johannessen, Johannes Langeveld, Ingrid Melle, Stein Opjordsmoen, Jan Ivar Røssberg, Bjørn Rishovd Rund, K Sundet, Per Vaglum, Svein Friis, Thomas McGlashan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Objective: Early detection in first-episode psychosis confers advantages for negative, cognitive, and depressive symptoms after 1, 2, and 5 years, but longitudinal effects are unknown. The authors investigated the differences in symptoms and recovery after 10 years between regional health care sectors with and without a comprehensive program for the early detection of psychosis.

    Method: The authors evaluated 281 patients (early detection, N=141) 18 to 65 years old with a first episode of nonaffective psychosis between 1997 and 2001. Of these, 101 patients in the early-detection area and 73 patients in the usual-detection area were followed up at 10 years, and the authors compared their symptoms and recovery.

    Results: A significantly higher percentage of early-detection patients had recovered at the 10-year follow-up relative to usual-detection patients. This held true despite more severely ill patients dropping out of the study in the usual-detection area. Except for higher levels of excitative symptoms in the early-detection area, there were no symptom differences between the groups. Early-detection recovery rates were higher largely because of higher employment rates for patients in this group.

    Conclusions: Early detection of first-episode psychosis appears to increase the chances of milder deficits and superior functioning. The mechanisms by which this strategy improves the long-term prognosis of psychosis remain speculative. Nevertheless, our findings over 10 years may indicate that a prognostic link exists between the timing of intervention and outcome that deserves additional study.
    OriginalsprogEngelsk
    TidsskriftAmerican Journal of Psychiatry
    Vol/bind169
    Udgave nummer4
    Sider (fra-til)374-380
    ISSN0002-953X
    DOI
    StatusUdgivet - 2012

    Citer dette

    Simonsen, E., Hegelstad, W. T. W., Larsen, T. K., Auestad, B., Evensen, J., Haahr, U. H., ... McGlashan, T. (2012). Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome. American Journal of Psychiatry, 169(4), 374-380. https://doi.org/10.1176/appi.ajp.2011.11030459
    Simonsen, Erik ; Hegelstad, Wenche ten Welden ; Larsen, Tor Ketil ; Auestad, B ; Evensen, Julie ; Haahr, Ulrik Helt ; Joa, Inge ; Johannessen, Jan Olav ; Langeveld, Johannes ; Melle, Ingrid ; Opjordsmoen, Stein ; Røssberg, Jan Ivar ; Rund, Bjørn Rishovd ; Sundet, K ; Vaglum, Per ; Friis, Svein ; McGlashan, Thomas. / Long-term follow-up of the TIPS early detection in psychosis study : effects on 10-year outcome. I: American Journal of Psychiatry. 2012 ; Bind 169, Nr. 4. s. 374-380.
    @article{19639be7c742402cb067db486f63ddbf,
    title = "Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome",
    abstract = "Objective: Early detection in first-episode psychosis confers advantages for negative, cognitive, and depressive symptoms after 1, 2, and 5 years, but longitudinal effects are unknown. The authors investigated the differences in symptoms and recovery after 10 years between regional health care sectors with and without a comprehensive program for the early detection of psychosis.Method: The authors evaluated 281 patients (early detection, N=141) 18 to 65 years old with a first episode of nonaffective psychosis between 1997 and 2001. Of these, 101 patients in the early-detection area and 73 patients in the usual-detection area were followed up at 10 years, and the authors compared their symptoms and recovery.Results: A significantly higher percentage of early-detection patients had recovered at the 10-year follow-up relative to usual-detection patients. This held true despite more severely ill patients dropping out of the study in the usual-detection area. Except for higher levels of excitative symptoms in the early-detection area, there were no symptom differences between the groups. Early-detection recovery rates were higher largely because of higher employment rates for patients in this group.Conclusions: Early detection of first-episode psychosis appears to increase the chances of milder deficits and superior functioning. The mechanisms by which this strategy improves the long-term prognosis of psychosis remain speculative. Nevertheless, our findings over 10 years may indicate that a prognostic link exists between the timing of intervention and outcome that deserves additional study.",
    author = "Erik Simonsen and Hegelstad, {Wenche ten Welden} and Larsen, {Tor Ketil} and B Auestad and Julie Evensen and Haahr, {Ulrik Helt} and Inge Joa and Johannessen, {Jan Olav} and Johannes Langeveld and Ingrid Melle and Stein Opjordsmoen and R{\o}ssberg, {Jan Ivar} and Rund, {Bj{\o}rn Rishovd} and K Sundet and Per Vaglum and Svein Friis and Thomas McGlashan",
    year = "2012",
    doi = "10.1176/appi.ajp.2011.11030459",
    language = "English",
    volume = "169",
    pages = "374--380",
    journal = "American Journal of Psychiatry",
    issn = "0002-953X",
    publisher = "American Psychiatric Publishing, Inc.",
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    Simonsen, E, Hegelstad, WTW, Larsen, TK, Auestad, B, Evensen, J, Haahr, UH, Joa, I, Johannessen, JO, Langeveld, J, Melle, I, Opjordsmoen, S, Røssberg, JI, Rund, BR, Sundet, K, Vaglum, P, Friis, S & McGlashan, T 2012, 'Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome', American Journal of Psychiatry, bind 169, nr. 4, s. 374-380. https://doi.org/10.1176/appi.ajp.2011.11030459

    Long-term follow-up of the TIPS early detection in psychosis study : effects on 10-year outcome. / Simonsen, Erik; Hegelstad, Wenche ten Welden; Larsen, Tor Ketil; Auestad, B; Evensen, Julie; Haahr, Ulrik Helt; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes; Melle, Ingrid; Opjordsmoen, Stein; Røssberg, Jan Ivar; Rund, Bjørn Rishovd; Sundet, K; Vaglum, Per; Friis, Svein; McGlashan, Thomas.

    I: American Journal of Psychiatry, Bind 169, Nr. 4, 2012, s. 374-380.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Long-term follow-up of the TIPS early detection in psychosis study

    T2 - effects on 10-year outcome

    AU - Simonsen, Erik

    AU - Hegelstad, Wenche ten Welden

    AU - Larsen, Tor Ketil

    AU - Auestad, B

    AU - Evensen, Julie

    AU - Haahr, Ulrik Helt

    AU - Joa, Inge

    AU - Johannessen, Jan Olav

    AU - Langeveld, Johannes

    AU - Melle, Ingrid

    AU - Opjordsmoen, Stein

    AU - Røssberg, Jan Ivar

    AU - Rund, Bjørn Rishovd

    AU - Sundet, K

    AU - Vaglum, Per

    AU - Friis, Svein

    AU - McGlashan, Thomas

    PY - 2012

    Y1 - 2012

    N2 - Objective: Early detection in first-episode psychosis confers advantages for negative, cognitive, and depressive symptoms after 1, 2, and 5 years, but longitudinal effects are unknown. The authors investigated the differences in symptoms and recovery after 10 years between regional health care sectors with and without a comprehensive program for the early detection of psychosis.Method: The authors evaluated 281 patients (early detection, N=141) 18 to 65 years old with a first episode of nonaffective psychosis between 1997 and 2001. Of these, 101 patients in the early-detection area and 73 patients in the usual-detection area were followed up at 10 years, and the authors compared their symptoms and recovery.Results: A significantly higher percentage of early-detection patients had recovered at the 10-year follow-up relative to usual-detection patients. This held true despite more severely ill patients dropping out of the study in the usual-detection area. Except for higher levels of excitative symptoms in the early-detection area, there were no symptom differences between the groups. Early-detection recovery rates were higher largely because of higher employment rates for patients in this group.Conclusions: Early detection of first-episode psychosis appears to increase the chances of milder deficits and superior functioning. The mechanisms by which this strategy improves the long-term prognosis of psychosis remain speculative. Nevertheless, our findings over 10 years may indicate that a prognostic link exists between the timing of intervention and outcome that deserves additional study.

    AB - Objective: Early detection in first-episode psychosis confers advantages for negative, cognitive, and depressive symptoms after 1, 2, and 5 years, but longitudinal effects are unknown. The authors investigated the differences in symptoms and recovery after 10 years between regional health care sectors with and without a comprehensive program for the early detection of psychosis.Method: The authors evaluated 281 patients (early detection, N=141) 18 to 65 years old with a first episode of nonaffective psychosis between 1997 and 2001. Of these, 101 patients in the early-detection area and 73 patients in the usual-detection area were followed up at 10 years, and the authors compared their symptoms and recovery.Results: A significantly higher percentage of early-detection patients had recovered at the 10-year follow-up relative to usual-detection patients. This held true despite more severely ill patients dropping out of the study in the usual-detection area. Except for higher levels of excitative symptoms in the early-detection area, there were no symptom differences between the groups. Early-detection recovery rates were higher largely because of higher employment rates for patients in this group.Conclusions: Early detection of first-episode psychosis appears to increase the chances of milder deficits and superior functioning. The mechanisms by which this strategy improves the long-term prognosis of psychosis remain speculative. Nevertheless, our findings over 10 years may indicate that a prognostic link exists between the timing of intervention and outcome that deserves additional study.

    U2 - 10.1176/appi.ajp.2011.11030459

    DO - 10.1176/appi.ajp.2011.11030459

    M3 - Journal article

    VL - 169

    SP - 374

    EP - 380

    JO - American Journal of Psychiatry

    JF - American Journal of Psychiatry

    SN - 0002-953X

    IS - 4

    ER -