There is limited evidence regarding a possible association between exposure to ambient air pollutants and the risk of non-Hodgkin lymphoma (NHL). Previous epidemiological studies have relied on crude estimations for air pollution exposure and/or small numbers of NHL cases. The objective of our study was to analyze this association based on air pollution modeled at the address level and NHL cases identified from the nationwide Danish Cancer Registry. We identified 20,874 incident NHL cases diagnosed between 1989 and 2014 and randomly selected 41,749 controls matched on age and gender among the entire Danish population. We used conditional logistic regression to estimate odds ratios (ORs) and adjusted for individual and neighborhood level sociodemographic variables. There was no association between exposure to PM2.5, BC, O3, SO2 or NO2 and overall risk of NHL but several air pollutants were associated with higher risk of follicular lymphoma, but statistically insignificant, for example, PM2.5 (OR = 1.15 per 5 μg/m3; 95% CI: 0.98–1.34) and lower risk for diffuse large B-cell lymphoma (OR = 0.92 per 5 μg/m3; 95% CI: 0.82–1.03). In this population-based study, we did not observe any convincing evidence of a higher overall risk for NHL with higher exposure to ambient air pollutants.
Bibliografisk noteFunding Information:
The research was funded by Nordforsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir—Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries). The funding source had no involvement in the study design, collection, analysis, interpretation, writing and decision to submit for publication.