Logical knowledge representation of regulatory relations in biomedical pathways

Sine Zambach, Jens Ulrik Hansen

Publikation: Bidrag til bog/antologi/rapportKonferencebidrag i proceedingsForskningpeer review

Abstract

Knowledge on regulatory relations, in for example regulatory pathways in biology, is used widely in experiment design by biomedical researchers and in systems biology. The knowledge has typically either been represented through simple graphs or through very expressive differential equation simulations of smaller parts of a pathway.

In this work we suggest a knowledge representation of the most basic relations in regulatory processes regulates, positively regulates and negatively regulates in logics based on a semantic analysis. We discuss the usage of these relations in biology and in articial intelligence for hypothesis development in drug discovery.

OriginalsprogEngelsk
TitelITBAM 2010 : 1st International Conference on Information Technology in Bio- and Medical Informatics
RedaktørerS. Khuri, L. Lhotská, N. Pisanti
Antal sider14
ForlagSpringer
Publikationsdato2010
Sider186-200
StatusUdgivet - 2010
Begivenhed1st International Conference on Information Technology in Bio- and Medical Informatics 2010 - Bilbao, Spanien
Varighed: 30 aug. 20103 sep. 2010
Konferencens nummer: 1

Konference

Konference1st International Conference on Information Technology in Bio- and Medical Informatics 2010
Nummer1
LandSpanien
ByBilbao
Periode30/08/201003/09/2010
NavnLecture Notes in Computer Science
Vol/bind6266
ISSN0302-9743

Emneord

  • Formelle relationer
  • Vidensrepræsentation
  • Biomedicinske ontologier
  • Formelle ontologier

Citer dette

Zambach, S., & Hansen, J. U. (2010). Logical knowledge representation of regulatory relations in biomedical pathways. I S. Khuri, L. Lhotská, & N. Pisanti (red.), ITBAM 2010: 1st International Conference on Information Technology in Bio- and Medical Informatics (s. 186-200). Springer. Lecture Notes in Computer Science, Bind. 6266