Limited efficacy of hydroxyurea in lowering of the JAK2 V617F allele burden

Thomas Stauffer Larsen*, Niels Pallisgaard, Karin de Stricker, Michael Boe Møller, Hans Carl Hasselbalch

*Corresponding author

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Abstract

Besides being an invaluable marker of clonal disease in chronic myeloproliferative disorders (CMPDs), the JAK2 V617F mutation and the mutated allele burden have an impact on disease phenotype and may provide information on prognosis. Recently, hydroxyurea (HU) has been shown to induce a rapid decline in the JAK2 V617F allele burden. The aim of the present study was to assess the dynamics of the JAK2 V617F allele burden during long-term treatment with HU in a series of patients with CMPDs. The JAK2 V617F allele burden was determined by quantitative PCR in 24 patients of whom 17 received HU, four received anagrelide and three were followed without any cytoreductive therapy. During a median follow-up of 24.2 months, no significant reductions in the JAK2 V617F allele burden were seen in patients treated with HU. We conclude that HU has only a limited effect on the JAK2 V617F allele burden in CMPD.

OriginalsprogEngelsk
TidsskriftHematology
Vol/bind14
Udgave nummer1
Sider (fra-til)11-15
Antal sider5
ISSN1024-5332
DOI
StatusUdgivet - 2009
Udgivet eksterntJa

Emneord

  • Hydroxyurea
  • JAK2V617F mutation
  • Myeloproliferative
  • Remission

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