Lack of the RNA chaperone hfq attenuates pathogenicity of several Escherichia coli pathotypes towards Caenorhabditis elegans

Martin Saxtorph Bojer; Henrik Jakobsen; Carsten Struve; Karen A. Krogfelt; Anders Løbner-Olesen

doi:10.1016/j.micinf.2012.06.002

Lack of the RNA chaperone hfq attenuates pathogenicity of several Escherichia coli pathotypes towards Caenorhabditis elegans

Martin Saxtorph Bojer, Henrik Jakobsen, Carsten Struve, Karen A. Krogfelt, Anders Løbner-Olesen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Escherichia coli is an important agent of Gram-negative bacterial infections worldwide, being one of the leading causes of diarrhoea and urinary tract infections. Strategies to understand pathogenesis and develop therapeutic compounds include the use of the nematode Caenorhabditis elegans as a model for virulence characterization and screening for novel antimicrobial entities. Several E. coli human pathotypes are also pathogenic towards C. elegans, and we show here that lack of the RNA chaperone Hfq significantly reduces pathogenicity of VTEC, EAEC, and UPEC in the nematode model. Thus, Hfq is intrinsically essential to pathogenic E. coli for survival and virulence exerted in the C. elegans host.

Originalsprog	Engelsk
Tidsskrift	Microbes and Infection
Vol/bind	14
Udgave nummer	12
Sider (fra-til)	1034-1039
ISSN	1286-4579
DOI	https://doi.org/10.1016/j.micinf.2012.06.002
Status	Udgivet - 2012

Link til dokument

10.1016/j.micinf.2012.06.002

Citer dette

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title = "Lack of the RNA chaperone hfq attenuates pathogenicity of several Escherichia coli pathotypes towards Caenorhabditis elegans ",

abstract = "Escherichia coli is an important agent of Gram-negative bacterial infections worldwide, being one of the leading causes of diarrhoea and urinary tract infections. Strategies to understand pathogenesis and develop therapeutic compounds include the use of the nematode Caenorhabditis elegans as a model for virulence characterization and screening for novel antimicrobial entities. Several E. coli human pathotypes are also pathogenic towards C. elegans, and we show here that lack of the RNA chaperone Hfq significantly reduces pathogenicity of VTEC, EAEC, and UPEC in the nematode model. Thus, Hfq is intrinsically essential to pathogenic E. coli for survival and virulence exerted in the C. elegans host.",

author = "Bojer, {Martin Saxtorph} and Henrik Jakobsen and Carsten Struve and Krogfelt, {Karen A.} and Anders L{\o}bner-Olesen",

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T1 - Lack of the RNA chaperone hfq attenuates pathogenicity of several Escherichia coli pathotypes towards Caenorhabditis elegans

AU - Bojer, Martin Saxtorph

AU - Jakobsen, Henrik

AU - Struve, Carsten

AU - Krogfelt, Karen A.

AU - Løbner-Olesen, Anders

PY - 2012

Y1 - 2012

N2 - Escherichia coli is an important agent of Gram-negative bacterial infections worldwide, being one of the leading causes of diarrhoea and urinary tract infections. Strategies to understand pathogenesis and develop therapeutic compounds include the use of the nematode Caenorhabditis elegans as a model for virulence characterization and screening for novel antimicrobial entities. Several E. coli human pathotypes are also pathogenic towards C. elegans, and we show here that lack of the RNA chaperone Hfq significantly reduces pathogenicity of VTEC, EAEC, and UPEC in the nematode model. Thus, Hfq is intrinsically essential to pathogenic E. coli for survival and virulence exerted in the C. elegans host.

AB - Escherichia coli is an important agent of Gram-negative bacterial infections worldwide, being one of the leading causes of diarrhoea and urinary tract infections. Strategies to understand pathogenesis and develop therapeutic compounds include the use of the nematode Caenorhabditis elegans as a model for virulence characterization and screening for novel antimicrobial entities. Several E. coli human pathotypes are also pathogenic towards C. elegans, and we show here that lack of the RNA chaperone Hfq significantly reduces pathogenicity of VTEC, EAEC, and UPEC in the nematode model. Thus, Hfq is intrinsically essential to pathogenic E. coli for survival and virulence exerted in the C. elegans host.

U2 - 10.1016/j.micinf.2012.06.002

DO - 10.1016/j.micinf.2012.06.002

M3 - Journal article

SN - 1286-4579

VL - 14

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EP - 1039

JO - Microbes and Infection

JF - Microbes and Infection

IS - 12

ER -