Isolation and preparation of cytotoxic chromanone acids from the bark of Calophyllum dongnaiense

Tri Hieu Nguyen, Poul Erik Hansen, Fritz Duus, Gørg Heilmann, Dinh Hung Pham, Lien Hoa Dieu Nguyen

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Three chromanone acids, blancoic acid (1), isoblancoic acid (2) and chapelieric acid (3), were isolated from the bark of Calophyllum dongnaiense Pierre collected in Dong Nai Province. Their structures were elucidated using spectroscopic techniques (1-D and 2-D NMR, UV, IR and MS) as well as chemical methods. Cytotoxicity of compounds 1-3 and their 5-O-acetylated and methylated derivatives against Hela cell line was examined.
TidsskriftJournal of Chemistry
Sider (fra-til)347-51
Antal sider5
StatusUdgivet - 2009


  • Cytotoxicity
  • Calophyllum dongnaiense

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