Introducing the hypothome: A way to integrate predicted proteins in interactomes

Claus Desler, Sine Zambach, Prashanth Suravajhala, Lene Juel Rasmussen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome
    OriginalsprogEngelsk
    TidsskriftInternational Journal of Bioinformatics Research and Applications
    Vol/bind10
    Udgave nummer6
    Sider (fra-til)647-652
    ISSN1744-5485
    DOI
    StatusUdgivet - 2014

    Citer dette

    Desler, Claus ; Zambach, Sine ; Suravajhala, Prashanth ; Rasmussen, Lene Juel. / Introducing the hypothome: A way to integrate predicted proteins in interactomes. I: International Journal of Bioinformatics Research and Applications. 2014 ; Bind 10, Nr. 6. s. 647-652.
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    abstract = "An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome",
    author = "Claus Desler and Sine Zambach and Prashanth Suravajhala and Rasmussen, {Lene Juel}",
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    Introducing the hypothome: A way to integrate predicted proteins in interactomes. / Desler, Claus; Zambach, Sine; Suravajhala, Prashanth; Rasmussen, Lene Juel.

    I: International Journal of Bioinformatics Research and Applications, Bind 10, Nr. 6, 2014, s. 647-652.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Introducing the hypothome: A way to integrate predicted proteins in interactomes

    AU - Desler, Claus

    AU - Zambach, Sine

    AU - Suravajhala, Prashanth

    AU - Rasmussen, Lene Juel

    PY - 2014

    Y1 - 2014

    N2 - An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome

    AB - An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome

    U2 - 10.1504/IJBRA.2014.065247

    DO - 10.1504/IJBRA.2014.065247

    M3 - Journal article

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    SP - 647

    EP - 652

    JO - International Journal of Bioinformatics Research and Applications

    JF - International Journal of Bioinformatics Research and Applications

    SN - 1744-5485

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    ER -