Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen, Ulla Vogel, Jane Christensen, Rikke D. Hansen, Håkan Wallin, Kim Overvad, Anne Tjønneland, Janne Schurmann Tolstrup

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study.

    Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.
    OriginalsprogEngelsk
    TidsskriftCancer Letters
    Vol/bind295
    Udgave nummer2
    Sider (fra-til)191-197
    ISSN0304-3835
    DOI
    StatusUdgivet - 2010

    Emneord

      Citer dette

      Benzon Larsen, Signe ; Vogel, Ulla ; Christensen, Jane ; Hansen, Rikke D. ; Wallin, Håkan ; Overvad, Kim ; Tjønneland, Anne ; Tolstrup, Janne Schurmann. / Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. I: Cancer Letters. 2010 ; Bind 295, Nr. 2. s. 191-197.
      @article{a510f88902c9406cb68025af344db5a0,
      title = "Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer",
      abstract = "Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14{\%} (95{\%} CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.",
      keywords = "Prospective study, Population-based study, Gene–environment interaction, Alcohol, Alcohol dehydrogenase, Breast cancer",
      author = "{Benzon Larsen}, Signe and Ulla Vogel and Jane Christensen and Hansen, {Rikke D.} and H{\aa}kan Wallin and Kim Overvad and Anne Tj{\o}nneland and Tolstrup, {Janne Schurmann}",
      year = "2010",
      doi = "10.1016/j.canlet.2010.02.023",
      language = "English",
      volume = "295",
      pages = "191--197",
      journal = "Cancer Letters",
      issn = "0304-3835",
      publisher = "Elsevier Ireland Ltd",
      number = "2",

      }

      Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. / Benzon Larsen, Signe ; Vogel, Ulla; Christensen, Jane ; Hansen, Rikke D.; Wallin, Håkan; Overvad, Kim; Tjønneland, Anne; Tolstrup, Janne Schurmann.

      I: Cancer Letters, Bind 295, Nr. 2, 2010, s. 191-197.

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

      TY - JOUR

      T1 - Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

      AU - Benzon Larsen, Signe

      AU - Vogel, Ulla

      AU - Christensen, Jane

      AU - Hansen, Rikke D.

      AU - Wallin, Håkan

      AU - Overvad, Kim

      AU - Tjønneland, Anne

      AU - Tolstrup, Janne Schurmann

      PY - 2010

      Y1 - 2010

      N2 - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

      AB - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

      KW - Prospective study

      KW - Population-based study

      KW - Gene–environment interaction

      KW - Alcohol

      KW - Alcohol dehydrogenase

      KW - Breast cancer

      U2 - 10.1016/j.canlet.2010.02.023

      DO - 10.1016/j.canlet.2010.02.023

      M3 - Journal article

      VL - 295

      SP - 191

      EP - 197

      JO - Cancer Letters

      JF - Cancer Letters

      SN - 0304-3835

      IS - 2

      ER -