Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe  Benzon Larsen; Ulla Vogel; Jane  Christensen; Rikke D. Hansen; Håkan Wallin; Kim Overvad; Anne Tjønneland; Janne Schurmann Tolstrup

doi:10.1016/j.canlet.2010.02.023

Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen, Ulla Vogel, Jane Christensen, Rikke D. Hansen, Håkan Wallin, Kim Overvad, Anne Tjønneland, Janne Schurmann Tolstrup

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study.

Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

Originalsprog	Engelsk
Tidsskrift	Cancer Letters
Vol/bind	295
Udgave nummer	2
Sider (fra-til)	191-197
ISSN	0304-3835
DOI	https://doi.org/10.1016/j.canlet.2010.02.023
Status	Udgivet - 2010

Link til dokument

10.1016/j.canlet.2010.02.023

Citer dette

Benzon Larsen, S., Vogel, U., Christensen, J., Hansen, R. D., Wallin, H., Overvad, K., Tjønneland, A., & Tolstrup, J. S. (2010). Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. Cancer Letters, 295(2), 191-197. https://doi.org/10.1016/j.canlet.2010.02.023

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title = "Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer",

abstract = "Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk. ",

keywords = "Prospective study, Population-based study, Gene–environment interaction, Alcohol, Alcohol dehydrogenase, Breast cancer",

author = "{Benzon Larsen}, Signe and Ulla Vogel and Jane Christensen and Hansen, {Rikke D.} and H{\aa}kan Wallin and Kim Overvad and Anne Tj{\o}nneland and Tolstrup, {Janne Schurmann}",

year = "2010",

doi = "10.1016/j.canlet.2010.02.023",

language = "English",

volume = "295",

pages = "191--197",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

Benzon Larsen, S, Vogel, U, Christensen, J, Hansen, RD, Wallin, H, Overvad, K, Tjønneland, A & Tolstrup, JS 2010, 'Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer', Cancer Letters, bind 295, nr. 2, s. 191-197. https://doi.org/10.1016/j.canlet.2010.02.023

Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. / Benzon Larsen, Signe ; Vogel, Ulla; Christensen, Jane et al.
I: Cancer Letters, Bind 295, Nr. 2, 2010, s. 191-197.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

AU - Benzon Larsen, Signe

AU - Vogel, Ulla

AU - Christensen, Jane

AU - Hansen, Rikke D.

AU - Wallin, Håkan

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Tolstrup, Janne Schurmann

PY - 2010

Y1 - 2010

N2 - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

AB - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

KW - Prospective study

KW - Population-based study

KW - Gene–environment interaction

KW - Alcohol

KW - Alcohol dehydrogenase

KW - Breast cancer

U2 - 10.1016/j.canlet.2010.02.023

DO - 10.1016/j.canlet.2010.02.023

M3 - Journal article

SN - 0304-3835

VL - 295

SP - 191

EP - 197

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -