Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen, Ulla Vogel, Jane Christensen, Rikke D. Hansen, Håkan Wallin, Kim Overvad, Anne Tjønneland, Janne Schurmann Tolstrup

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study.

    Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.
    OriginalsprogEngelsk
    TidsskriftCancer Letters
    Vol/bind295
    Udgave nummer2
    Sider (fra-til)191-197
    ISSN0304-3835
    DOI
    StatusUdgivet - 2010

    Citer dette

    Benzon Larsen, Signe ; Vogel, Ulla ; Christensen, Jane ; Hansen, Rikke D. ; Wallin, Håkan ; Overvad, Kim ; Tjønneland, Anne ; Tolstrup, Janne Schurmann. / Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. I: Cancer Letters. 2010 ; Bind 295, Nr. 2. s. 191-197.
    @article{a510f88902c9406cb68025af344db5a0,
    title = "Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer",
    abstract = "Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14{\%} (95{\%} CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.",
    keywords = "Prospective study, Population-based study, Gene–environment interaction, Alcohol, Alcohol dehydrogenase, Breast cancer",
    author = "{Benzon Larsen}, Signe and Ulla Vogel and Jane Christensen and Hansen, {Rikke D.} and H{\aa}kan Wallin and Kim Overvad and Anne Tj{\o}nneland and Tolstrup, {Janne Schurmann}",
    year = "2010",
    doi = "10.1016/j.canlet.2010.02.023",
    language = "English",
    volume = "295",
    pages = "191--197",
    journal = "Cancer Letters",
    issn = "0304-3835",
    publisher = "Elsevier Ireland Ltd",
    number = "2",

    }

    Benzon Larsen, S, Vogel, U, Christensen, J, Hansen, RD, Wallin, H, Overvad, K, Tjønneland, A & Tolstrup, JS 2010, 'Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer', Cancer Letters, bind 295, nr. 2, s. 191-197. https://doi.org/10.1016/j.canlet.2010.02.023

    Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. / Benzon Larsen, Signe ; Vogel, Ulla; Christensen, Jane ; Hansen, Rikke D.; Wallin, Håkan; Overvad, Kim; Tjønneland, Anne; Tolstrup, Janne Schurmann.

    I: Cancer Letters, Bind 295, Nr. 2, 2010, s. 191-197.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

    AU - Benzon Larsen, Signe

    AU - Vogel, Ulla

    AU - Christensen, Jane

    AU - Hansen, Rikke D.

    AU - Wallin, Håkan

    AU - Overvad, Kim

    AU - Tjønneland, Anne

    AU - Tolstrup, Janne Schurmann

    PY - 2010

    Y1 - 2010

    N2 - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

    AB - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg272Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04–1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

    KW - Prospective study

    KW - Population-based study

    KW - Gene–environment interaction

    KW - Alcohol

    KW - Alcohol dehydrogenase

    KW - Breast cancer

    U2 - 10.1016/j.canlet.2010.02.023

    DO - 10.1016/j.canlet.2010.02.023

    M3 - Journal article

    VL - 295

    SP - 191

    EP - 197

    JO - Cancer Letters

    JF - Cancer Letters

    SN - 0304-3835

    IS - 2

    ER -