Innervation of the pancreas in development and disease

Publikation: Bidrag til tidsskriftReviewpeer review

Abstract

The autonomic nervous system innervates the pancreas by sympathetic, parasympathetic and sensory branches during early organogenesis, starting with neural crest cell invasion and formation of an intrinsic neuronal network. Several studies have demonstrated that signals from pancreatic neural crest cells direct pancreatic endocrinogenesis. Likewise, autonomic neurons have been shown to regulate pancreatic islet formation, and have also been implicated in type I diabetes. Here, we provide an overview of recent progress in mapping pancreatic innervation and understanding the interactions between pancreatic neurons, epithelial morphogenesis and cell differentiation. Finally, we discuss pancreas innervation as a factor in the development of diabetes.

OriginalsprogEngelsk
Artikelnummerdev202254
TidsskriftDevelopment
Vol/bind151
Udgave nummer2
ISSN1477-9129
DOI
StatusUdgivet - 15 jan. 2024

Emneord

  • Autonomic nervous system
  • Diabetes
  • Endocrine differentiation
  • Innervation
  • Organogenesis
  • Pancreas

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