Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB.

Stephane Duigou, Kristine Groth Knudsen, Ole Skovgaard, Elisabeth S. Egan, Anders Løbner-Olesen, Matthew K Waldor

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

    Abstract

    Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.
    OriginalsprogEngelsk
    TidsskriftJournal of Bacteriology
    Vol/bind188
    Udgave nummer17
    Sider (fra-til)6419-24
    Antal sider6
    ISSN0021-9193
    StatusUdgivet - 2006

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