Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States

Daniel M. Weinberger, Lone Simonsen, Richard Jordan, Claudia Steiner, Mark Miller, Cecile Viboud

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND:
Infection with influenza virus increases the risk for developing pneumococcal disease. The A/H1N1 influenza pandemic in autumn 2009 provided a unique opportunity to evaluate this relationship.

METHODS:
Using weekly age-, state-, and cause-specific hospitalizations from the US State Inpatient Databases of the Healthcare Cost and Utilization Project 2003-2009, we quantified the increase in pneumococcal pneumonia hospitalization rates above a seasonal baseline during the pandemic period.

RESULTS:
We found a significant increase in pneumococcal hospitalizations from late August to mid-December 2009, which corresponded to the timing of highest pandemic influenza activity. Individuals aged 5-19 years, who have a low baseline level of pneumococcal disease, experienced the largest relative increase in pneumococcal hospitalizations (ratio, 1.6 [95% confidence interval {CI}, 1.4-1.7]), whereas the largest absolute increase was observed among individuals aged 40-64 years. In contrast, there was no excess disease in the elderly. Geographical variation in the timing of excess pneumococcal hospitalizations matched geographical patterns for the fall pandemic influenza wave.

CONCLUSIONS:
The 2009 influenza pandemic had a significant impact on the rate of pneumococcal pneumonia hospitalizations, with the magnitude of this effect varying between age groups and states, mirroring observed variations in influenza activity.
OriginalsprogEngelsk
TidsskriftJournal of Infectious Diseases
Vol/bind205
Udgave nummer3
Sider (fra-til)458-465
ISSN0022-1899
StatusUdgivet - feb. 2012

Citer dette

Weinberger, D. M., Simonsen, L., Jordan, R., Steiner, C., Miller, M., & Viboud, C. (2012). Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States. Journal of Infectious Diseases, 205(3), 458-465.
Weinberger, Daniel M. ; Simonsen, Lone ; Jordan, Richard ; Steiner, Claudia ; Miller, Mark ; Viboud, Cecile. / Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States. I: Journal of Infectious Diseases. 2012 ; Bind 205, Nr. 3. s. 458-465.
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title = "Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States",
abstract = "BACKGROUND:Infection with influenza virus increases the risk for developing pneumococcal disease. The A/H1N1 influenza pandemic in autumn 2009 provided a unique opportunity to evaluate this relationship.METHODS:Using weekly age-, state-, and cause-specific hospitalizations from the US State Inpatient Databases of the Healthcare Cost and Utilization Project 2003-2009, we quantified the increase in pneumococcal pneumonia hospitalization rates above a seasonal baseline during the pandemic period.RESULTS:We found a significant increase in pneumococcal hospitalizations from late August to mid-December 2009, which corresponded to the timing of highest pandemic influenza activity. Individuals aged 5-19 years, who have a low baseline level of pneumococcal disease, experienced the largest relative increase in pneumococcal hospitalizations (ratio, 1.6 [95{\%} confidence interval {CI}, 1.4-1.7]), whereas the largest absolute increase was observed among individuals aged 40-64 years. In contrast, there was no excess disease in the elderly. Geographical variation in the timing of excess pneumococcal hospitalizations matched geographical patterns for the fall pandemic influenza wave.CONCLUSIONS:The 2009 influenza pandemic had a significant impact on the rate of pneumococcal pneumonia hospitalizations, with the magnitude of this effect varying between age groups and states, mirroring observed variations in influenza activity.",
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Weinberger, DM, Simonsen, L, Jordan, R, Steiner, C, Miller, M & Viboud, C 2012, 'Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States', Journal of Infectious Diseases, bind 205, nr. 3, s. 458-465.

Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States. / Weinberger, Daniel M.; Simonsen, Lone; Jordan, Richard; Steiner, Claudia; Miller, Mark; Viboud, Cecile.

I: Journal of Infectious Diseases, Bind 205, Nr. 3, 02.2012, s. 458-465.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States

AU - Weinberger, Daniel M.

AU - Simonsen, Lone

AU - Jordan, Richard

AU - Steiner, Claudia

AU - Miller, Mark

AU - Viboud, Cecile

PY - 2012/2

Y1 - 2012/2

N2 - BACKGROUND:Infection with influenza virus increases the risk for developing pneumococcal disease. The A/H1N1 influenza pandemic in autumn 2009 provided a unique opportunity to evaluate this relationship.METHODS:Using weekly age-, state-, and cause-specific hospitalizations from the US State Inpatient Databases of the Healthcare Cost and Utilization Project 2003-2009, we quantified the increase in pneumococcal pneumonia hospitalization rates above a seasonal baseline during the pandemic period.RESULTS:We found a significant increase in pneumococcal hospitalizations from late August to mid-December 2009, which corresponded to the timing of highest pandemic influenza activity. Individuals aged 5-19 years, who have a low baseline level of pneumococcal disease, experienced the largest relative increase in pneumococcal hospitalizations (ratio, 1.6 [95% confidence interval {CI}, 1.4-1.7]), whereas the largest absolute increase was observed among individuals aged 40-64 years. In contrast, there was no excess disease in the elderly. Geographical variation in the timing of excess pneumococcal hospitalizations matched geographical patterns for the fall pandemic influenza wave.CONCLUSIONS:The 2009 influenza pandemic had a significant impact on the rate of pneumococcal pneumonia hospitalizations, with the magnitude of this effect varying between age groups and states, mirroring observed variations in influenza activity.

AB - BACKGROUND:Infection with influenza virus increases the risk for developing pneumococcal disease. The A/H1N1 influenza pandemic in autumn 2009 provided a unique opportunity to evaluate this relationship.METHODS:Using weekly age-, state-, and cause-specific hospitalizations from the US State Inpatient Databases of the Healthcare Cost and Utilization Project 2003-2009, we quantified the increase in pneumococcal pneumonia hospitalization rates above a seasonal baseline during the pandemic period.RESULTS:We found a significant increase in pneumococcal hospitalizations from late August to mid-December 2009, which corresponded to the timing of highest pandemic influenza activity. Individuals aged 5-19 years, who have a low baseline level of pneumococcal disease, experienced the largest relative increase in pneumococcal hospitalizations (ratio, 1.6 [95% confidence interval {CI}, 1.4-1.7]), whereas the largest absolute increase was observed among individuals aged 40-64 years. In contrast, there was no excess disease in the elderly. Geographical variation in the timing of excess pneumococcal hospitalizations matched geographical patterns for the fall pandemic influenza wave.CONCLUSIONS:The 2009 influenza pandemic had a significant impact on the rate of pneumococcal pneumonia hospitalizations, with the magnitude of this effect varying between age groups and states, mirroring observed variations in influenza activity.

M3 - Journal article

VL - 205

SP - 458

EP - 465

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

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