Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women

Kathleen Maletic Neuzil, George W. Reed, Edward F. Mitchel, Lone Simonsen, Marie R. Griffin

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

This study sought to quantify influenza-related serious morbidity in pregnant women, as measured by hospitalizations for or death from selected acute cardiopulmonary conditions during predefined influenza seasons. The study population included women aged 15–44 years who were enrolled in the Tennessee Medicaid program for at least 180 days between 1974 and 1993. In a nested case-control study, 4, 369 women with a first study event during influenza season were compared with 21, 845 population controls. The odds ratios associated with study events increased from 1.44 (95% confidence interval (Cl) 0.97–2.15) for women at 14–20 weeks‘ gestation to 4.67 (95% Cl 3.42–6.39) for those at 37–42 weeks in comparison with postpartum women. A retrospective cohort analysis, which controlled for risk factors identified in the case-control study, identified 22, 824 study events during 1, 393, 166 women-years of follow-up. Women in their third trimester without other identified risk factors for influenza morbidity had an event rate of 21.7 per 10, 000 women-months during influenza season. Approximately half of this morbidity, 10.5 (95% Cl 6.7–14.3) events per 10, 000 women-months, was attributable to influenza. Influenza-attributable risks in comparable nonpregnant and postpartum women were 1.91 (95% Cl 1.51–2.31) and 1.16 (95% Cl -0.09 to 2.42) per 10, 000 women-months, respectively. The data suggest that, out of every 10, 000 women in their third trimester without other identified risk factors who experience an average influenza season of 2.5 months, 25 will be hospitalized with influenza-related morbidity. Am J Epidemiol 1998; 148: 1094-102.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Epidemiology
Vol/bind148
Udgave nummer11
Antal sider8
ISSN0002-9262
StatusUdgivet - 1998
Udgivet eksterntJa

Citer dette

Neuzil, Kathleen Maletic ; Reed, George W. ; Mitchel, Edward F. ; Simonsen, Lone ; Griffin, Marie R. / Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women. I: American Journal of Epidemiology. 1998 ; Bind 148, Nr. 11.
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title = "Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women",
abstract = "This study sought to quantify influenza-related serious morbidity in pregnant women, as measured by hospitalizations for or death from selected acute cardiopulmonary conditions during predefined influenza seasons. The study population included women aged 15–44 years who were enrolled in the Tennessee Medicaid program for at least 180 days between 1974 and 1993. In a nested case-control study, 4, 369 women with a first study event during influenza season were compared with 21, 845 population controls. The odds ratios associated with study events increased from 1.44 (95{\%} confidence interval (Cl) 0.97–2.15) for women at 14–20 weeks‘ gestation to 4.67 (95{\%} Cl 3.42–6.39) for those at 37–42 weeks in comparison with postpartum women. A retrospective cohort analysis, which controlled for risk factors identified in the case-control study, identified 22, 824 study events during 1, 393, 166 women-years of follow-up. Women in their third trimester without other identified risk factors for influenza morbidity had an event rate of 21.7 per 10, 000 women-months during influenza season. Approximately half of this morbidity, 10.5 (95{\%} Cl 6.7–14.3) events per 10, 000 women-months, was attributable to influenza. Influenza-attributable risks in comparable nonpregnant and postpartum women were 1.91 (95{\%} Cl 1.51–2.31) and 1.16 (95{\%} Cl -0.09 to 2.42) per 10, 000 women-months, respectively. The data suggest that, out of every 10, 000 women in their third trimester without other identified risk factors who experience an average influenza season of 2.5 months, 25 will be hospitalized with influenza-related morbidity. Am J Epidemiol 1998; 148: 1094-102.",
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Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women. / Neuzil, Kathleen Maletic; Reed, George W.; Mitchel, Edward F.; Simonsen, Lone; Griffin, Marie R.

I: American Journal of Epidemiology, Bind 148, Nr. 11, 1998.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women

AU - Neuzil, Kathleen Maletic

AU - Reed, George W.

AU - Mitchel, Edward F.

AU - Simonsen, Lone

AU - Griffin, Marie R.

PY - 1998

Y1 - 1998

N2 - This study sought to quantify influenza-related serious morbidity in pregnant women, as measured by hospitalizations for or death from selected acute cardiopulmonary conditions during predefined influenza seasons. The study population included women aged 15–44 years who were enrolled in the Tennessee Medicaid program for at least 180 days between 1974 and 1993. In a nested case-control study, 4, 369 women with a first study event during influenza season were compared with 21, 845 population controls. The odds ratios associated with study events increased from 1.44 (95% confidence interval (Cl) 0.97–2.15) for women at 14–20 weeks‘ gestation to 4.67 (95% Cl 3.42–6.39) for those at 37–42 weeks in comparison with postpartum women. A retrospective cohort analysis, which controlled for risk factors identified in the case-control study, identified 22, 824 study events during 1, 393, 166 women-years of follow-up. Women in their third trimester without other identified risk factors for influenza morbidity had an event rate of 21.7 per 10, 000 women-months during influenza season. Approximately half of this morbidity, 10.5 (95% Cl 6.7–14.3) events per 10, 000 women-months, was attributable to influenza. Influenza-attributable risks in comparable nonpregnant and postpartum women were 1.91 (95% Cl 1.51–2.31) and 1.16 (95% Cl -0.09 to 2.42) per 10, 000 women-months, respectively. The data suggest that, out of every 10, 000 women in their third trimester without other identified risk factors who experience an average influenza season of 2.5 months, 25 will be hospitalized with influenza-related morbidity. Am J Epidemiol 1998; 148: 1094-102.

AB - This study sought to quantify influenza-related serious morbidity in pregnant women, as measured by hospitalizations for or death from selected acute cardiopulmonary conditions during predefined influenza seasons. The study population included women aged 15–44 years who were enrolled in the Tennessee Medicaid program for at least 180 days between 1974 and 1993. In a nested case-control study, 4, 369 women with a first study event during influenza season were compared with 21, 845 population controls. The odds ratios associated with study events increased from 1.44 (95% confidence interval (Cl) 0.97–2.15) for women at 14–20 weeks‘ gestation to 4.67 (95% Cl 3.42–6.39) for those at 37–42 weeks in comparison with postpartum women. A retrospective cohort analysis, which controlled for risk factors identified in the case-control study, identified 22, 824 study events during 1, 393, 166 women-years of follow-up. Women in their third trimester without other identified risk factors for influenza morbidity had an event rate of 21.7 per 10, 000 women-months during influenza season. Approximately half of this morbidity, 10.5 (95% Cl 6.7–14.3) events per 10, 000 women-months, was attributable to influenza. Influenza-attributable risks in comparable nonpregnant and postpartum women were 1.91 (95% Cl 1.51–2.31) and 1.16 (95% Cl -0.09 to 2.42) per 10, 000 women-months, respectively. The data suggest that, out of every 10, 000 women in their third trimester without other identified risk factors who experience an average influenza season of 2.5 months, 25 will be hospitalized with influenza-related morbidity. Am J Epidemiol 1998; 148: 1094-102.

M3 - Journal article

VL - 148

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 11

ER -