High interleukin-6 mRNA expression is a predictor of relapse in colon cancer

Jesper Olsen, Lene T. Kirkeby, Jørgen Olsen, Susanne Eiholm, Per Jess, Ismael Gögenur, Jesper Troelsen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    AIM: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression. MATERIALS AND METHODS: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at -80°C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model. RESULTS: IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95% CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95% CI=1.07-4.40; p<0.05). CONCLUSION: Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse.
    OriginalsprogEngelsk
    TidsskriftAnticancer Research
    Vol/bind35
    Udgave nummer4
    Sider (fra-til)2235-40
    ISSN0250-7005
    StatusUdgivet - 2015

    Citer dette

    Olsen, J., Kirkeby, L. T., Olsen, J., Eiholm, S., Jess, P., Gögenur, I., & Troelsen, J. (2015). High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. Anticancer Research, 35(4), 2235-40.
    Olsen, Jesper ; Kirkeby, Lene T. ; Olsen, Jørgen ; Eiholm, Susanne ; Jess, Per ; Gögenur, Ismael ; Troelsen, Jesper. / High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. I: Anticancer Research. 2015 ; Bind 35, Nr. 4. s. 2235-40.
    @article{392ab72df5cc48b293ab4c0a9803bf39,
    title = "High interleukin-6 mRNA expression is a predictor of relapse in colon cancer",
    abstract = "Aim: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression. Materials and Methods: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at −80°C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model. Results: IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95{\%} CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95{\%} CI=1.07-4.40; p<0.05). Conclusion: Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse.",
    author = "Jesper Olsen and Kirkeby, {Lene T.} and J{\o}rgen Olsen and Susanne Eiholm and Per Jess and Ismael G{\"o}genur and Jesper Troelsen",
    year = "2015",
    language = "English",
    volume = "35",
    pages = "2235--40",
    journal = "Anticancer Research",
    issn = "0250-7005",
    publisher = "International Institute of Anticancer Research",
    number = "4",

    }

    Olsen, J, Kirkeby, LT, Olsen, J, Eiholm, S, Jess, P, Gögenur, I & Troelsen, J 2015, 'High interleukin-6 mRNA expression is a predictor of relapse in colon cancer', Anticancer Research, bind 35, nr. 4, s. 2235-40.

    High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. / Olsen, Jesper; Kirkeby, Lene T.; Olsen, Jørgen; Eiholm, Susanne; Jess, Per; Gögenur, Ismael; Troelsen, Jesper.

    I: Anticancer Research, Bind 35, Nr. 4, 2015, s. 2235-40.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - High interleukin-6 mRNA expression is a predictor of relapse in colon cancer

    AU - Olsen, Jesper

    AU - Kirkeby, Lene T.

    AU - Olsen, Jørgen

    AU - Eiholm, Susanne

    AU - Jess, Per

    AU - Gögenur, Ismael

    AU - Troelsen, Jesper

    PY - 2015

    Y1 - 2015

    N2 - Aim: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression. Materials and Methods: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at −80°C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model. Results: IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95% CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95% CI=1.07-4.40; p<0.05). Conclusion: Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse.

    AB - Aim: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression. Materials and Methods: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at −80°C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model. Results: IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95% CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95% CI=1.07-4.40; p<0.05). Conclusion: Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse.

    M3 - Journal article

    VL - 35

    SP - 2235

    EP - 2240

    JO - Anticancer Research

    JF - Anticancer Research

    SN - 0250-7005

    IS - 4

    ER -

    Olsen J, Kirkeby LT, Olsen J, Eiholm S, Jess P, Gögenur I et al. High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. Anticancer Research. 2015;35(4):2235-40.