Resumé
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | B B A - Reviews on Cancer |
| Vol/bind | 1806 |
| Udgave nummer | 1 |
| Sider (fra-til) | 58-65 |
| ISSN | 0304-419X |
| Status | Udgivet - 2010 |
Citer dette
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Helicobacter pylori infection generates genetic instability in gastric cells. / Machado, Ana Manuel; Figueiredo, C.; Seruca, R.; Rasmussen, Lene Juel.
I: B B A - Reviews on Cancer, Bind 1806, Nr. 1, 2010, s. 58-65.Publikation: Bidrag til tidsskrift › Review › Forskning › peer review
TY - JOUR
T1 - Helicobacter pylori infection generates genetic instability in gastric cells
AU - Machado, Ana Manuel
AU - Figueiredo, C.
AU - Seruca, R.
AU - Rasmussen, Lene Juel
PY - 2010
Y1 - 2010
N2 - The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome
AB - The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome
KW - H. pylori
KW - Gastric cancer
KW - DNA repair
KW - Genetic instability
M3 - Review
VL - 1806
SP - 58
EP - 65
JO - B B A - Reviews on Cancer
JF - B B A - Reviews on Cancer
SN - 0304-419X
IS - 1
ER -