Helicobacter pylori infection generates genetic instability in gastric cells

Ana Manuel Machado, C. Figueiredo, R. Seruca, Lene Juel Rasmussen

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Resumé

    The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome
    OriginalsprogEngelsk
    TidsskriftB B A - Reviews on Cancer
    Vol/bind1806
    Udgave nummer1
    Sider (fra-til)58-65
    ISSN0304-419X
    StatusUdgivet - 2010

    Citer dette

    Machado, A. M., Figueiredo, C., Seruca, R., & Rasmussen, L. J. (2010). Helicobacter pylori infection generates genetic instability in gastric cells. B B A - Reviews on Cancer, 1806(1), 58-65.
    Machado, Ana Manuel ; Figueiredo, C. ; Seruca, R. ; Rasmussen, Lene Juel. / Helicobacter pylori infection generates genetic instability in gastric cells. I: B B A - Reviews on Cancer. 2010 ; Bind 1806, Nr. 1. s. 58-65.
    @article{7db7eade877c44baa4036855b867c6a0,
    title = "Helicobacter pylori infection generates genetic instability in gastric cells",
    abstract = "The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome",
    keywords = "H. pylori, Gastric cancer, DNA repair, Genetic instability",
    author = "Machado, {Ana Manuel} and C. Figueiredo and R. Seruca and Rasmussen, {Lene Juel}",
    year = "2010",
    language = "English",
    volume = "1806",
    pages = "58--65",
    journal = "B B A - Reviews on Cancer",
    issn = "0304-419X",
    publisher = "Elsevier BV",
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    Machado, AM, Figueiredo, C, Seruca, R & Rasmussen, LJ 2010, 'Helicobacter pylori infection generates genetic instability in gastric cells', B B A - Reviews on Cancer, bind 1806, nr. 1, s. 58-65.

    Helicobacter pylori infection generates genetic instability in gastric cells. / Machado, Ana Manuel; Figueiredo, C.; Seruca, R.; Rasmussen, Lene Juel.

    I: B B A - Reviews on Cancer, Bind 1806, Nr. 1, 2010, s. 58-65.

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    TY - JOUR

    T1 - Helicobacter pylori infection generates genetic instability in gastric cells

    AU - Machado, Ana Manuel

    AU - Figueiredo, C.

    AU - Seruca, R.

    AU - Rasmussen, Lene Juel

    PY - 2010

    Y1 - 2010

    N2 - The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome

    AB - The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome

    KW - H. pylori

    KW - Gastric cancer

    KW - DNA repair

    KW - Genetic instability

    M3 - Review

    VL - 1806

    SP - 58

    EP - 65

    JO - B B A - Reviews on Cancer

    JF - B B A - Reviews on Cancer

    SN - 0304-419X

    IS - 1

    ER -

    Machado AM, Figueiredo C, Seruca R, Rasmussen LJ. Helicobacter pylori infection generates genetic instability in gastric cells. B B A - Reviews on Cancer. 2010;1806(1):58-65.