GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer

Rikke Dalgaard Hansen, Britta Naimi Krath, Kirsten Frederiksen, Anne Tjønneland, Kim Overvad, Nina Roswall, Steffen Loft, Lars Ove Dragsted, Ulla Vogel, Ole Lundsgaard Raaschou-Nielsen

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    Resumé

    GPX1 encoding the enzyme glutathione peroxiclase 1 (GPX1) and hOGG1 encoding the 8-oxoguanine glycosylase 1 (OGG1) may counteract oxidative stress and resulting DNA damage associated with lifestyle-related exposures. We examined whether the polymorphisms GPX1 Pro(198)Leu and OGG1 Ser(326)CyS or low erythrocyte GPX enzyme activity in pre-diagnostic blood samples are associated with colorectal cancer risk, and assessed possible interactions between the polymorphisms or enzyme activity and various lifestyle factors in relation to colorectal cancer risk. Additionally, we studied whether the GPX1 Pro(198)Leu polymorphism and several lifestyle factors predict GPX activity in erythrocytes. The present study was nested within the prospective "Diet, Cancer and Health" study of 57,053 Danes including 375 colorectal cancer cases and a comparison group of 779 individuals matched on gender. Biomaterial was sampled and information on lifestyle factors was obtained from questionnaires filled in at enrolment in 1993-1997. GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer. We observed a higher risk associated with alcohol consumption and smoking among homozygous GPX1 (198)Leu carriers, with incidence rate ratios for colorectal cancer of 1.45 (95% CI: 1.17-1.81, P = 0.02) per 10 g alcohol intake per day and 2.56 (95% CI: 0.99-6.61, P = 0.02) among ever smokers compared with never smokers at enrolment. Erythrocyte GPX activity was influenced by the GPX1 Pro(198)Leu genotype, gender, smoking intensity. and intake of fruits and vegetables. Our results indicate that lifestyle-related oxidative stress may be a risk factor for colorectal cancer among subjects with a lowered defence
    OriginalsprogEngelsk
    TidsskriftMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
    Vol/bind664
    Udgave nummer1-2
    Sider (fra-til)13-19
    ISSN0027-5107
    DOI
    StatusUdgivet - 2009

    Emneord

      Citer dette

      Hansen, Rikke Dalgaard ; Krath, Britta Naimi ; Frederiksen, Kirsten ; Tjønneland, Anne ; Overvad, Kim ; Roswall, Nina ; Loft, Steffen ; Dragsted, Lars Ove ; Vogel, Ulla ; Raaschou-Nielsen, Ole Lundsgaard. / GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer. I: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2009 ; Bind 664, Nr. 1-2. s. 13-19.
      @article{a0972ea0fa0011de89af000ea68e967b,
      title = "GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer",
      abstract = "GPX1 encoding the enzyme glutathione peroxiclase 1 (GPX1) and hOGG1 encoding the 8-oxoguanine glycosylase 1 (OGG1) may counteract oxidative stress and resulting DNA damage associated with lifestyle-related exposures. We examined whether the polymorphisms GPX1 Pro(198)Leu and OGG1 Ser(326)CyS or low erythrocyte GPX enzyme activity in pre-diagnostic blood samples are associated with colorectal cancer risk, and assessed possible interactions between the polymorphisms or enzyme activity and various lifestyle factors in relation to colorectal cancer risk. Additionally, we studied whether the GPX1 Pro(198)Leu polymorphism and several lifestyle factors predict GPX activity in erythrocytes. The present study was nested within the prospective {"}Diet, Cancer and Health{"} study of 57,053 Danes including 375 colorectal cancer cases and a comparison group of 779 individuals matched on gender. Biomaterial was sampled and information on lifestyle factors was obtained from questionnaires filled in at enrolment in 1993-1997. GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer. We observed a higher risk associated with alcohol consumption and smoking among homozygous GPX1 (198)Leu carriers, with incidence rate ratios for colorectal cancer of 1.45 (95{\%} CI: 1.17-1.81, P = 0.02) per 10 g alcohol intake per day and 2.56 (95{\%} CI: 0.99-6.61, P = 0.02) among ever smokers compared with never smokers at enrolment. Erythrocyte GPX activity was influenced by the GPX1 Pro(198)Leu genotype, gender, smoking intensity. and intake of fruits and vegetables. Our results indicate that lifestyle-related oxidative stress may be a risk factor for colorectal cancer among subjects with a lowered defence",
      keywords = "Colorectal cancer, GPX1, OGG1, Gene-environment interaction, Enzyme activity, Oxidative stress",
      author = "Hansen, {Rikke Dalgaard} and Krath, {Britta Naimi} and Kirsten Frederiksen and Anne Tj{\o}nneland and Kim Overvad and Nina Roswall and Steffen Loft and Dragsted, {Lars Ove} and Ulla Vogel and Raaschou-Nielsen, {Ole Lundsgaard}",
      year = "2009",
      doi = "10.1016/j.mrfmmm.2009.01.009",
      language = "English",
      volume = "664",
      pages = "13--19",
      journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",
      issn = "0027-5107",
      publisher = "Elsevier BV",
      number = "1-2",

      }

      Hansen, RD, Krath, BN, Frederiksen, K, Tjønneland, A, Overvad, K, Roswall, N, Loft, S, Dragsted, LO, Vogel, U & Raaschou-Nielsen, OL 2009, 'GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer' Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, bind 664, nr. 1-2, s. 13-19. https://doi.org/10.1016/j.mrfmmm.2009.01.009

      GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer. / Hansen, Rikke Dalgaard; Krath, Britta Naimi; Frederiksen, Kirsten; Tjønneland, Anne; Overvad, Kim; Roswall, Nina; Loft, Steffen; Dragsted, Lars Ove; Vogel, Ulla; Raaschou-Nielsen, Ole Lundsgaard.

      I: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Bind 664, Nr. 1-2, 2009, s. 13-19.

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

      TY - JOUR

      T1 - GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer

      AU - Hansen, Rikke Dalgaard

      AU - Krath, Britta Naimi

      AU - Frederiksen, Kirsten

      AU - Tjønneland, Anne

      AU - Overvad, Kim

      AU - Roswall, Nina

      AU - Loft, Steffen

      AU - Dragsted, Lars Ove

      AU - Vogel, Ulla

      AU - Raaschou-Nielsen, Ole Lundsgaard

      PY - 2009

      Y1 - 2009

      N2 - GPX1 encoding the enzyme glutathione peroxiclase 1 (GPX1) and hOGG1 encoding the 8-oxoguanine glycosylase 1 (OGG1) may counteract oxidative stress and resulting DNA damage associated with lifestyle-related exposures. We examined whether the polymorphisms GPX1 Pro(198)Leu and OGG1 Ser(326)CyS or low erythrocyte GPX enzyme activity in pre-diagnostic blood samples are associated with colorectal cancer risk, and assessed possible interactions between the polymorphisms or enzyme activity and various lifestyle factors in relation to colorectal cancer risk. Additionally, we studied whether the GPX1 Pro(198)Leu polymorphism and several lifestyle factors predict GPX activity in erythrocytes. The present study was nested within the prospective "Diet, Cancer and Health" study of 57,053 Danes including 375 colorectal cancer cases and a comparison group of 779 individuals matched on gender. Biomaterial was sampled and information on lifestyle factors was obtained from questionnaires filled in at enrolment in 1993-1997. GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer. We observed a higher risk associated with alcohol consumption and smoking among homozygous GPX1 (198)Leu carriers, with incidence rate ratios for colorectal cancer of 1.45 (95% CI: 1.17-1.81, P = 0.02) per 10 g alcohol intake per day and 2.56 (95% CI: 0.99-6.61, P = 0.02) among ever smokers compared with never smokers at enrolment. Erythrocyte GPX activity was influenced by the GPX1 Pro(198)Leu genotype, gender, smoking intensity. and intake of fruits and vegetables. Our results indicate that lifestyle-related oxidative stress may be a risk factor for colorectal cancer among subjects with a lowered defence

      AB - GPX1 encoding the enzyme glutathione peroxiclase 1 (GPX1) and hOGG1 encoding the 8-oxoguanine glycosylase 1 (OGG1) may counteract oxidative stress and resulting DNA damage associated with lifestyle-related exposures. We examined whether the polymorphisms GPX1 Pro(198)Leu and OGG1 Ser(326)CyS or low erythrocyte GPX enzyme activity in pre-diagnostic blood samples are associated with colorectal cancer risk, and assessed possible interactions between the polymorphisms or enzyme activity and various lifestyle factors in relation to colorectal cancer risk. Additionally, we studied whether the GPX1 Pro(198)Leu polymorphism and several lifestyle factors predict GPX activity in erythrocytes. The present study was nested within the prospective "Diet, Cancer and Health" study of 57,053 Danes including 375 colorectal cancer cases and a comparison group of 779 individuals matched on gender. Biomaterial was sampled and information on lifestyle factors was obtained from questionnaires filled in at enrolment in 1993-1997. GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer. We observed a higher risk associated with alcohol consumption and smoking among homozygous GPX1 (198)Leu carriers, with incidence rate ratios for colorectal cancer of 1.45 (95% CI: 1.17-1.81, P = 0.02) per 10 g alcohol intake per day and 2.56 (95% CI: 0.99-6.61, P = 0.02) among ever smokers compared with never smokers at enrolment. Erythrocyte GPX activity was influenced by the GPX1 Pro(198)Leu genotype, gender, smoking intensity. and intake of fruits and vegetables. Our results indicate that lifestyle-related oxidative stress may be a risk factor for colorectal cancer among subjects with a lowered defence

      KW - Colorectal cancer

      KW - GPX1

      KW - OGG1

      KW - Gene-environment interaction

      KW - Enzyme activity

      KW - Oxidative stress

      U2 - 10.1016/j.mrfmmm.2009.01.009

      DO - 10.1016/j.mrfmmm.2009.01.009

      M3 - Journal article

      VL - 664

      SP - 13

      EP - 19

      JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

      JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

      SN - 0027-5107

      IS - 1-2

      ER -