Flat affect and social functioning: a 10 year follow-up study of first episode psychosis patients

Erik Simonsen; Julie Evensen; Jan Ivar Røsberg; Helene Barder; Ulrik Helt Haahr; Wenche ten Welden Hegelstad; Inge Joa; Jan Olav Johannessen; Tor Ketil Larsen; Ingrid Melle; Stein Opjordsmoen; Bjørn Rishovd Rund; Per Vaglum; Thomas McGlashan; Svein Friis

doi:10.1016/j.schres.2012.04.019

Flat affect and social functioning: a 10 year follow-up study of first episode psychosis patients

Erik Simonsen, Julie Evensen, Jan Ivar Røsberg, Helene Barder, Ulrik Helt Haahr, Wenche ten Welden Hegelstad, Inge Joa, Jan Olav Johannessen, Tor Ketil Larsen, Ingrid Melle, Stein Opjordsmoen, Bjørn Rishovd Rund, Per Vaglum, Thomas McGlashan, Svein Friis

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Background: Affective flattening has been described as enduring, but long term follow-up studies of first episode psychosis patients are lacking.
Objective: The aim of this study was to follow the symptom development of flat affect (FA), over a 10 year follow-up period, with focus on prevalence, predictors and outcome factors including social functioning.
Methods: Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. These were followed on PANSS item N1 (FA) from baseline through 5 follow-up assessments over 10 years. Patients were grouped as having never-present, improving, deteriorating, fluctuating
or enduring FA. The groups were compared on baseline variables, variables at 10 year follow-up, and social functioning throughout the follow-up period.
Results: Twenty nine percent never displayed FA, 66% had improving, deteriorating or fluctuating FA, while 5% of patients had enduring FA. Premorbid social function predicted enduring FA. The patients with enduring,
fluctuating and deteriorating FA did poorer on all outcome variables, including remission and recovery rates. The enduring FA group did significantly poorer in social functioning over the 10 year period.
Conclusions: FA is expressed at some point of time in the majority of FEP patients in a 10 year follow-up period, and appears more fluctuant than expected from the relevant literature. FA is associated with poorer outcome
after 10 years, and enduring FA to poorer social function at all points of assessment.

Originalsprog	Engelsk
Tidsskrift	Schizophrenia Research
Vol/bind	139
Udgave nummer	1-3
Sider (fra-til)	99-104
ISSN	0920-9964
DOI	https://doi.org/10.1016/j.schres.2012.04.019
Status	Udgivet - 2012

Emneord

Negative symptoms
Flat affect
outcome
First episode psychosis

Link til dokument

10.1016/j.schres.2012.04.019

Citer dette

Simonsen, E., Evensen, J., Røsberg, J. I., Barder, H., Haahr, U. H., Hegelstad, W. T. W., Joa, I., Johannessen, J. O., Larsen, T. K., Melle, I., Opjordsmoen, S., Rund, B. R., Vaglum, P., McGlashan, T., & Friis, S. (2012). Flat affect and social functioning: a 10 year follow-up study of first episode psychosis patients. Schizophrenia Research, 139(1-3), 99-104. https://doi.org/10.1016/j.schres.2012.04.019

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title = "Flat affect and social functioning: a 10 year follow-up study of first episode psychosis patients",

abstract = "Background: Affective flattening has been described as enduring, but long term follow-up studies of first episode psychosis patients are lacking.Objective: The aim of this study was to follow the symptom development of flat affect (FA), over a 10 year follow-up period, with focus on prevalence, predictors and outcome factors including social functioning.Methods: Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. These were followed on PANSS item N1 (FA) from baseline through 5 follow-up assessments over 10 years. Patients were grouped as having never-present, improving, deteriorating, fluctuatingor enduring FA. The groups were compared on baseline variables, variables at 10 year follow-up, and social functioning throughout the follow-up period.Results: Twenty nine percent never displayed FA, 66% had improving, deteriorating or fluctuating FA, while 5% of patients had enduring FA. Premorbid social function predicted enduring FA. The patients with enduring,fluctuating and deteriorating FA did poorer on all outcome variables, including remission and recovery rates. The enduring FA group did significantly poorer in social functioning over the 10 year period.Conclusions: FA is expressed at some point of time in the majority of FEP patients in a 10 year follow-up period, and appears more fluctuant than expected from the relevant literature. FA is associated with poorer outcome after 10 years, and enduring FA to poorer social function at all points of assessment.",

keywords = "Negative symptoms, Flat affect, outcome, First episode psychosis",

author = "Erik Simonsen and Julie Evensen and R{\o}sberg, {Jan Ivar} and Helene Barder and Haahr, {Ulrik Helt} and Hegelstad, {Wenche ten Welden} and Inge Joa and Johannessen, {Jan Olav} and Larsen, {Tor Ketil} and Ingrid Melle and Stein Opjordsmoen and Rund, {Bj{\o}rn Rishovd} and Per Vaglum and Thomas McGlashan and Svein Friis",

year = "2012",

doi = "10.1016/j.schres.2012.04.019",

language = "English",

volume = "139",

pages = "99--104",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier BV",

number = "1-3",

}

Simonsen, E, Evensen, J, Røsberg, JI, Barder, H, Haahr, UH, Hegelstad, WTW, Joa, I, Johannessen, JO, Larsen, TK, Melle, I, Opjordsmoen, S, Rund, BR, Vaglum, P, McGlashan, T & Friis, S 2012, 'Flat affect and social functioning: a 10 year follow-up study of first episode psychosis patients', Schizophrenia Research, bind 139, nr. 1-3, s. 99-104. https://doi.org/10.1016/j.schres.2012.04.019

TY - JOUR

T1 - Flat affect and social functioning

T2 - a 10 year follow-up study of first episode psychosis patients

AU - Simonsen, Erik

AU - Evensen, Julie

AU - Røsberg, Jan Ivar

AU - Barder, Helene

AU - Haahr, Ulrik Helt

AU - Hegelstad, Wenche ten Welden

AU - Joa, Inge

AU - Johannessen, Jan Olav

AU - Larsen, Tor Ketil

AU - Melle, Ingrid

AU - Opjordsmoen, Stein

AU - Rund, Bjørn Rishovd

AU - Vaglum, Per

AU - McGlashan, Thomas

AU - Friis, Svein

PY - 2012

Y1 - 2012

N2 - Background: Affective flattening has been described as enduring, but long term follow-up studies of first episode psychosis patients are lacking.Objective: The aim of this study was to follow the symptom development of flat affect (FA), over a 10 year follow-up period, with focus on prevalence, predictors and outcome factors including social functioning.Methods: Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. These were followed on PANSS item N1 (FA) from baseline through 5 follow-up assessments over 10 years. Patients were grouped as having never-present, improving, deteriorating, fluctuatingor enduring FA. The groups were compared on baseline variables, variables at 10 year follow-up, and social functioning throughout the follow-up period.Results: Twenty nine percent never displayed FA, 66% had improving, deteriorating or fluctuating FA, while 5% of patients had enduring FA. Premorbid social function predicted enduring FA. The patients with enduring,fluctuating and deteriorating FA did poorer on all outcome variables, including remission and recovery rates. The enduring FA group did significantly poorer in social functioning over the 10 year period.Conclusions: FA is expressed at some point of time in the majority of FEP patients in a 10 year follow-up period, and appears more fluctuant than expected from the relevant literature. FA is associated with poorer outcome after 10 years, and enduring FA to poorer social function at all points of assessment.

AB - Background: Affective flattening has been described as enduring, but long term follow-up studies of first episode psychosis patients are lacking.Objective: The aim of this study was to follow the symptom development of flat affect (FA), over a 10 year follow-up period, with focus on prevalence, predictors and outcome factors including social functioning.Methods: Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. These were followed on PANSS item N1 (FA) from baseline through 5 follow-up assessments over 10 years. Patients were grouped as having never-present, improving, deteriorating, fluctuatingor enduring FA. The groups were compared on baseline variables, variables at 10 year follow-up, and social functioning throughout the follow-up period.Results: Twenty nine percent never displayed FA, 66% had improving, deteriorating or fluctuating FA, while 5% of patients had enduring FA. Premorbid social function predicted enduring FA. The patients with enduring,fluctuating and deteriorating FA did poorer on all outcome variables, including remission and recovery rates. The enduring FA group did significantly poorer in social functioning over the 10 year period.Conclusions: FA is expressed at some point of time in the majority of FEP patients in a 10 year follow-up period, and appears more fluctuant than expected from the relevant literature. FA is associated with poorer outcome after 10 years, and enduring FA to poorer social function at all points of assessment.

KW - Negative symptoms

KW - Flat affect

KW - outcome

KW - First episode psychosis

U2 - 10.1016/j.schres.2012.04.019

DO - 10.1016/j.schres.2012.04.019

M3 - Journal article

SN - 0920-9964

VL - 139

SP - 99

EP - 104

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -