Ferroxidase-Mediated Iron Oxide Biomineralization: Novel Pathways to Multifunctional Nanoparticles

Kornelius Zeth, Egbert Hoiczyk, Mitsuhiro Okuda

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Resumé

Iron oxide biomineralization occurs in all living organisms and typically involves protein compartments ranging from 5 to 100nm in size. The smallest iron-oxo particles are formed inside dodecameric Dps protein cages, while the structurally related ferritin compartments consist of twice as many identical protein subunits. The largest known compartments are encapsulins, icosahedra made of up to 180 protein subunits that harbor additional ferritin-like proteins in their interior. The formation of iron-oxo particles in all these compartments requires a series of steps including recruitment of iron, translocation, oxidation, nucleation, and storage, that are mediated by ferroxidase centers. Thus, compartmentalized iron oxide biomineralization yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications.
OriginalsprogEngelsk
TidsskriftTrends in Biochemical Sciences
Vol/bind41
Udgave nummer2
Sider (fra-til)190-203
ISSN0968-0004
DOI
StatusUdgivet - 2016

Citer dette

Zeth, Kornelius ; Hoiczyk, Egbert ; Okuda, Mitsuhiro. / Ferroxidase-Mediated Iron Oxide Biomineralization : Novel Pathways to Multifunctional Nanoparticles. I: Trends in Biochemical Sciences. 2016 ; Bind 41, Nr. 2. s. 190-203.
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abstract = "Iron oxide biomineralization occurs in all living organisms and typically involves protein compartments ranging from 5 to 100nm in size. The smallest iron-oxo particles are formed inside dodecameric Dps protein cages, while the structurally related ferritin compartments consist of twice as many identical protein subunits. The largest known compartments are encapsulins, icosahedra made of up to 180 protein subunits that harbor additional ferritin-like proteins in their interior. The formation of iron-oxo particles in all these compartments requires a series of steps including recruitment of iron, translocation, oxidation, nucleation, and storage, that are mediated by ferroxidase centers. Thus, compartmentalized iron oxide biomineralization yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications.",
author = "Kornelius Zeth and Egbert Hoiczyk and Mitsuhiro Okuda",
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Zeth, K, Hoiczyk, E & Okuda, M 2016, 'Ferroxidase-Mediated Iron Oxide Biomineralization: Novel Pathways to Multifunctional Nanoparticles' Trends in Biochemical Sciences, bind 41, nr. 2, s. 190-203. https://doi.org/10.1016/j.tibs.2015.11.011

Ferroxidase-Mediated Iron Oxide Biomineralization : Novel Pathways to Multifunctional Nanoparticles. / Zeth, Kornelius; Hoiczyk, Egbert; Okuda, Mitsuhiro.

I: Trends in Biochemical Sciences, Bind 41, Nr. 2, 2016, s. 190-203.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Ferroxidase-Mediated Iron Oxide Biomineralization

T2 - Novel Pathways to Multifunctional Nanoparticles

AU - Zeth, Kornelius

AU - Hoiczyk, Egbert

AU - Okuda, Mitsuhiro

PY - 2016

Y1 - 2016

N2 - Iron oxide biomineralization occurs in all living organisms and typically involves protein compartments ranging from 5 to 100nm in size. The smallest iron-oxo particles are formed inside dodecameric Dps protein cages, while the structurally related ferritin compartments consist of twice as many identical protein subunits. The largest known compartments are encapsulins, icosahedra made of up to 180 protein subunits that harbor additional ferritin-like proteins in their interior. The formation of iron-oxo particles in all these compartments requires a series of steps including recruitment of iron, translocation, oxidation, nucleation, and storage, that are mediated by ferroxidase centers. Thus, compartmentalized iron oxide biomineralization yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications.

AB - Iron oxide biomineralization occurs in all living organisms and typically involves protein compartments ranging from 5 to 100nm in size. The smallest iron-oxo particles are formed inside dodecameric Dps protein cages, while the structurally related ferritin compartments consist of twice as many identical protein subunits. The largest known compartments are encapsulins, icosahedra made of up to 180 protein subunits that harbor additional ferritin-like proteins in their interior. The formation of iron-oxo particles in all these compartments requires a series of steps including recruitment of iron, translocation, oxidation, nucleation, and storage, that are mediated by ferroxidase centers. Thus, compartmentalized iron oxide biomineralization yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications.

U2 - 10.1016/j.tibs.2015.11.011

DO - 10.1016/j.tibs.2015.11.011

M3 - Journal article

VL - 41

SP - 190

EP - 203

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 2

ER -

Zeth K, Hoiczyk E, Okuda M. Ferroxidase-Mediated Iron Oxide Biomineralization: Novel Pathways to Multifunctional Nanoparticles. Trends in Biochemical Sciences. 2016;41(2):190-203. https://doi.org/10.1016/j.tibs.2015.11.011

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