Fast and efficient green synthesis of thiosulfonate S-esters by microwave-supported permanganate oxidation of symmetrical disulfides

Luu Thi Xuan Thi, Thao-Tran Thi Nguyen, Thach Ngoc Le, Jens Spanget-Larsen, Fritz Duus

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Potassium permanganate absorbed on copper(II) sulfate pentahydrate has been found to be an efficient, inexpensive, and green oxidation agent for the synthesis of “symmetrical” thiosulfonate S-esters by oxidation of the corresponding symmetrical disulfides. The oxidation reactions were carried out under solvent-free reaction conditions within 15 min under the influence of microwave irradiation, as well as (for comparison) supported by conventional heating, to afford yields of the thiosulfonate S-esters in the range of 60–83%. The oxidation reaction appears to proceed (at least partly) via an intermediate symmetrical vic-disulfoxide
TidsskriftJournal of Sulfur Chemistry
Udgave nummer3
Sider (fra-til)340-350
Antal sider11
StatusUdgivet - 2015

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