Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

Meryem Benmarce; Kim Henriksen; Morten Karsdal; Signe Holm Nielsen

doi:10.3389/fneur.2025.1566228

Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

Meryem Benmarce^*, Kim Henriksen, Morten Karsdal, Signe Holm Nielsen

^*Corresponding author

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson’s disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all p < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.

Originalsprog	Engelsk
Artikelnummer	1566228
Tidsskrift	Frontiers in Neurology
Vol/bind	16
Antal sider	5
ISSN	1664-2295
DOI	https://doi.org/10.3389/fneur.2025.1566228
Status	Udgivet - 2025

Emneord

Biomarker
C1M
Parkinson’s disease
Tau-A
Tau-C

Link til dokument

10.3389/fneur.2025.1566228Licens: CC BY

Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s diseaseForlagets udgivne version, 778 KBLicens: CC BY

Citer dette

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AU - Karsdal, Morten

AU - Holm Nielsen, Signe

PY - 2025

Y1 - 2025

N2 - Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson’s disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all p < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.

AB - Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson’s disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all p < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.

KW - Biomarker

KW - C1M

KW - Parkinson’s disease

KW - Tau-A

KW - Tau-C

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KW - C1M

KW - Parkinson’s disease

KW - Tau-A

KW - Tau-C

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DO - 10.3389/fneur.2025.1566228

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AN - SCOPUS:105005291383

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JO - Frontiers in Neurology

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