Evolution, safety, and highly pathogenic influenza viruses

Marc Lipsitch, Joshua B Plotkin, Lone Simonsen, Barry Bloom

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Experience with influenza has shown that predictions of virus phenotype or fitness from nucleotide sequence are imperfect, and that predicting the timing and course of evolution is extremely difficult. Such uncertainty means that the risk of experiments with mammalian-transmissible, possibly highly virulent influenza viruses remains high even if some aspects of their laboratory biology are reassuring; it also implies limitations on the ability of laboratory observations to guide interpretation of surveillance of strains in the field. Given these considerations, we propose that future experiments with virulent pathogens whose accidental or deliberate release could lead to extensive spread in human populations should be limited by explicit risk-benefit considerations, in the United States and worldwide.
OriginalsprogEngelsk
TidsskriftScience
Vol/bind336
Udgave nummer6088
Sider (fra-til)1529–1531
ISSN0036-8075
StatusUdgivet - 2012

Citer dette

Lipsitch, M., Plotkin, J. B., Simonsen, L., & Bloom, B. (2012). Evolution, safety, and highly pathogenic influenza viruses. Science, 336(6088), 1529–1531.