Evaluation of the Magnitude of the 1993 Hantavirus Outbreak in the Southwestern United States

Lone Simonsen, Mary J. Dalton, Robert F. Breiman, Thomas Hennessy, Edith T. Umland, C. Mack Sewell, Pierre E. Rollin, Thomas G. Ksiazek, Clarence J. Peters

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

In May 1993, an outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was caused by the previously unrecognized Sin Nombre virus (SNV). Most HPS patients had an influenza-like prodrome, followed by rapid onset of pulmonary edema (fatality rate, 52%). To define the magnitude of the outbreak, patients with milder illnesses who sought medical care in the outbreak area during the outbreak period were assessed for infection with SNV. Of 299 study subjects, 43 had illnesses similar to the HPS prodrome. One laboratory finding, thrombocytopenia, was highly discriminatory between non-HPS patients (1%) and confirmed HPS patients (71%; P < .001) during the prodrome phase. No study subject had serologic evidence (IgM antibodies) of recent SNV infection. Five had IgG titers consistent with a previous hantavirus infection; 3 of these 5 were among the 43 patients who had illnesses similar to the HPS prodrome (P < .05). These data provide evidence that mild illness is rarely caused by SNV.
OriginalsprogEngelsk
TidsskriftJournal of Infectious Diseases
Vol/bind172
Udgave nummer3
Antal sider5
ISSN0022-1899
StatusUdgivet - 1995
Udgivet eksterntJa

Citer dette

Simonsen, L., Dalton, M. J., Breiman, R. F., Hennessy, T., Umland, E. T., Mack Sewell, C., ... Peters, C. J. (1995). Evaluation of the Magnitude of the 1993 Hantavirus Outbreak in the Southwestern United States. Journal of Infectious Diseases, 172(3).
Simonsen, Lone ; Dalton, Mary J. ; Breiman, Robert F. ; Hennessy, Thomas ; Umland, Edith T. ; Mack Sewell, C. ; Rollin, Pierre E. ; Ksiazek, Thomas G. ; Peters, Clarence J. / Evaluation of the Magnitude of the 1993 Hantavirus Outbreak in the Southwestern United States. I: Journal of Infectious Diseases. 1995 ; Bind 172, Nr. 3.
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title = "Evaluation of the Magnitude of the 1993 Hantavirus Outbreak in the Southwestern United States",
abstract = "In May 1993, an outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was caused by the previously unrecognized Sin Nombre virus (SNV). Most HPS patients had an influenza-like prodrome, followed by rapid onset of pulmonary edema (fatality rate, 52{\%}). To define the magnitude of the outbreak, patients with milder illnesses who sought medical care in the outbreak area during the outbreak period were assessed for infection with SNV. Of 299 study subjects, 43 had illnesses similar to the HPS prodrome. One laboratory finding, thrombocytopenia, was highly discriminatory between non-HPS patients (1{\%}) and confirmed HPS patients (71{\%}; P < .001) during the prodrome phase. No study subject had serologic evidence (IgM antibodies) of recent SNV infection. Five had IgG titers consistent with a previous hantavirus infection; 3 of these 5 were among the 43 patients who had illnesses similar to the HPS prodrome (P < .05). These data provide evidence that mild illness is rarely caused by SNV.",
author = "Lone Simonsen and Dalton, {Mary J.} and Breiman, {Robert F.} and Thomas Hennessy and Umland, {Edith T.} and {Mack Sewell}, C. and Rollin, {Pierre E.} and Ksiazek, {Thomas G.} and Peters, {Clarence J.}",
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Simonsen, L, Dalton, MJ, Breiman, RF, Hennessy, T, Umland, ET, Mack Sewell, C, Rollin, PE, Ksiazek, TG & Peters, CJ 1995, 'Evaluation of the Magnitude of the 1993 Hantavirus Outbreak in the Southwestern United States', Journal of Infectious Diseases, bind 172, nr. 3.

Evaluation of the Magnitude of the 1993 Hantavirus Outbreak in the Southwestern United States. / Simonsen, Lone; Dalton, Mary J.; Breiman, Robert F.; Hennessy, Thomas; Umland, Edith T. ; Mack Sewell, C. ; Rollin, Pierre E.; Ksiazek, Thomas G.; Peters, Clarence J.

I: Journal of Infectious Diseases, Bind 172, Nr. 3, 1995.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Evaluation of the Magnitude of the 1993 Hantavirus Outbreak in the Southwestern United States

AU - Simonsen, Lone

AU - Dalton, Mary J.

AU - Breiman, Robert F.

AU - Hennessy, Thomas

AU - Umland, Edith T.

AU - Mack Sewell, C.

AU - Rollin, Pierre E.

AU - Ksiazek, Thomas G.

AU - Peters, Clarence J.

PY - 1995

Y1 - 1995

N2 - In May 1993, an outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was caused by the previously unrecognized Sin Nombre virus (SNV). Most HPS patients had an influenza-like prodrome, followed by rapid onset of pulmonary edema (fatality rate, 52%). To define the magnitude of the outbreak, patients with milder illnesses who sought medical care in the outbreak area during the outbreak period were assessed for infection with SNV. Of 299 study subjects, 43 had illnesses similar to the HPS prodrome. One laboratory finding, thrombocytopenia, was highly discriminatory between non-HPS patients (1%) and confirmed HPS patients (71%; P < .001) during the prodrome phase. No study subject had serologic evidence (IgM antibodies) of recent SNV infection. Five had IgG titers consistent with a previous hantavirus infection; 3 of these 5 were among the 43 patients who had illnesses similar to the HPS prodrome (P < .05). These data provide evidence that mild illness is rarely caused by SNV.

AB - In May 1993, an outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was caused by the previously unrecognized Sin Nombre virus (SNV). Most HPS patients had an influenza-like prodrome, followed by rapid onset of pulmonary edema (fatality rate, 52%). To define the magnitude of the outbreak, patients with milder illnesses who sought medical care in the outbreak area during the outbreak period were assessed for infection with SNV. Of 299 study subjects, 43 had illnesses similar to the HPS prodrome. One laboratory finding, thrombocytopenia, was highly discriminatory between non-HPS patients (1%) and confirmed HPS patients (71%; P < .001) during the prodrome phase. No study subject had serologic evidence (IgM antibodies) of recent SNV infection. Five had IgG titers consistent with a previous hantavirus infection; 3 of these 5 were among the 43 patients who had illnesses similar to the HPS prodrome (P < .05). These data provide evidence that mild illness is rarely caused by SNV.

M3 - Journal article

VL - 172

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -