TY - JOUR
T1 - Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age
T2 - a Danish cohort study
AU - Nielsen, Katrine Finderup
AU - Nielsen, Lise Birk
AU - Lomholt, Frederikke Kristensen
AU - Nørgaard, Sarah Kristine
AU - Slotved, Hans Christian
AU - Dalby, Tine
AU - Fuursted, Kurt
AU - Jørgensen, Charlotte Sværke
AU - Valentiner-Branth, Palle
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - This study aimed to estimate the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPV23) against invasive pneumococcal disease (IPD) among individuals ≥ 65 years of age. We used Danish nationwide databases to obtain information on PPV23 vaccination, covariates, and IPD and linked data on an individual level using a unique personal identifier. A total of 948,263 individuals were included and followed between June 15, 2020, and September 18, 2021 (58.6% were vaccinated during follow-up). The adjusted vaccine effectiveness was 42% (95% confidence interval (CI): 9–63%) for all-serotype IPD and 58% (95% CI: 21–78%) for PPV23-serotype IPD, using no vaccination as the reference.
AB - This study aimed to estimate the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPV23) against invasive pneumococcal disease (IPD) among individuals ≥ 65 years of age. We used Danish nationwide databases to obtain information on PPV23 vaccination, covariates, and IPD and linked data on an individual level using a unique personal identifier. A total of 948,263 individuals were included and followed between June 15, 2020, and September 18, 2021 (58.6% were vaccinated during follow-up). The adjusted vaccine effectiveness was 42% (95% confidence interval (CI): 9–63%) for all-serotype IPD and 58% (95% CI: 21–78%) for PPV23-serotype IPD, using no vaccination as the reference.
KW - Epidemiology
KW - Invasive pneumococcal disease
KW - Pneumococcal polysaccharide vaccine
KW - Vaccine effectiveness
UR - http://www.scopus.com/inward/record.url?scp=85141043211&partnerID=8YFLogxK
U2 - 10.1007/s10096-022-04513-5
DO - 10.1007/s10096-022-04513-5
M3 - Journal article
C2 - 36282341
AN - SCOPUS:85141043211
SN - 0934-9723
VL - 41
SP - 1473
EP - 1477
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 12
ER -