TY - JOUR
T1 - Ecdysone Control of Developmental Transitions
T2 - Lessons from Drosophila Research
AU - Rewitz, Kim
AU - Yamanaka, Naoki
AU - O'Connor, Michael B.
PY - 2013
Y1 - 2013
N2 - The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent new advances in our understanding of ecdysone action have relied heavily on the application of Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, we focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage- and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signaling.
AB - The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent new advances in our understanding of ecdysone action have relied heavily on the application of Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, we focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage- and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signaling.
U2 - 10.1146/annurev-ento-120811-153608
DO - 10.1146/annurev-ento-120811-153608
M3 - Review
VL - 58
SP - 497
EP - 516
JO - Annual Review of Entomology
JF - Annual Review of Entomology
SN - 0066-4170
ER -