Early identification of non-remission in first-episode psychosis in a two-year outcome study

Erik Simonsen, Svein Friis, Stein Opjordsmoen, Erik Lykke Mortensen, Ulrik Haahr, Ingrid Melle, Inge Joa, Jan Olav Johannessen, Tor Ketil Larsen, Jan Ivar Røssberg, Bjørn Rishovd Rund, Per Vaglum, Thomas H. McGlashan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Objective: to identify predictors of non-remission in first-episode, non-affective psychosis.
    Method: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years.
    Results: One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotid over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n=48), remitted for <6 months (n=38) and for more than 6 months (n=207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks), respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years.
    Conclusion: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.
    OriginalsprogEngelsk
    TidsskriftActa Psychiatrica Scandinavica
    Vol/bind122
    Udgave nummer5
    Sider (fra-til)375-383
    Antal sider8
    ISSN0001-690X
    DOI
    StatusUdgivet - nov. 2010

    Citer dette

    Simonsen, E., Friis, S., Opjordsmoen, S., Mortensen, E. L., Haahr, U., Melle, I., ... McGlashan, T. H. (2010). Early identification of non-remission in first-episode psychosis in a two-year outcome study. Acta Psychiatrica Scandinavica, 122(5), 375-383. https://doi.org/10.1111/j.1600-0447.2010.01598.x
    Simonsen, Erik ; Friis, Svein ; Opjordsmoen, Stein ; Mortensen, Erik Lykke ; Haahr, Ulrik ; Melle, Ingrid ; Joa, Inge ; Johannessen, Jan Olav ; Larsen, Tor Ketil ; Røssberg, Jan Ivar ; Rund, Bjørn Rishovd ; Vaglum, Per ; McGlashan, Thomas H. / Early identification of non-remission in first-episode psychosis in a two-year outcome study. I: Acta Psychiatrica Scandinavica. 2010 ; Bind 122, Nr. 5. s. 375-383.
    @article{b244e2a371fc4cada352a40ba1dc0a52,
    title = "Early identification of non-remission in first-episode psychosis in a two-year outcome study",
    abstract = "Objective: to identify predictors of non-remission in first-episode, non-affective psychosis. Method: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. Results: One hundred and twenty-nine patients (43{\%}) remained psychotic at 3 months and 48 patients (16.4{\%}) remained psychotid over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n=48), remitted for <6 months (n=38) and for more than 6 months (n=207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks), respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years. Conclusion: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.",
    author = "Erik Simonsen and Svein Friis and Stein Opjordsmoen and Mortensen, {Erik Lykke} and Ulrik Haahr and Ingrid Melle and Inge Joa and Johannessen, {Jan Olav} and Larsen, {Tor Ketil} and R{\o}ssberg, {Jan Ivar} and Rund, {Bj{\o}rn Rishovd} and Per Vaglum and McGlashan, {Thomas H.}",
    year = "2010",
    month = "11",
    doi = "10.1111/j.1600-0447.2010.01598.x",
    language = "English",
    volume = "122",
    pages = "375--383",
    journal = "Acta Psychiatrica Scandinavica",
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    Simonsen, E, Friis, S, Opjordsmoen, S, Mortensen, EL, Haahr, U, Melle, I, Joa, I, Johannessen, JO, Larsen, TK, Røssberg, JI, Rund, BR, Vaglum, P & McGlashan, TH 2010, 'Early identification of non-remission in first-episode psychosis in a two-year outcome study', Acta Psychiatrica Scandinavica, bind 122, nr. 5, s. 375-383. https://doi.org/10.1111/j.1600-0447.2010.01598.x

    Early identification of non-remission in first-episode psychosis in a two-year outcome study. / Simonsen, Erik; Friis, Svein; Opjordsmoen, Stein; Mortensen, Erik Lykke; Haahr, Ulrik; Melle, Ingrid; Joa, Inge; Johannessen, Jan Olav; Larsen, Tor Ketil; Røssberg, Jan Ivar; Rund, Bjørn Rishovd; Vaglum, Per; McGlashan, Thomas H.

    I: Acta Psychiatrica Scandinavica, Bind 122, Nr. 5, 11.2010, s. 375-383.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Early identification of non-remission in first-episode psychosis in a two-year outcome study

    AU - Simonsen, Erik

    AU - Friis, Svein

    AU - Opjordsmoen, Stein

    AU - Mortensen, Erik Lykke

    AU - Haahr, Ulrik

    AU - Melle, Ingrid

    AU - Joa, Inge

    AU - Johannessen, Jan Olav

    AU - Larsen, Tor Ketil

    AU - Røssberg, Jan Ivar

    AU - Rund, Bjørn Rishovd

    AU - Vaglum, Per

    AU - McGlashan, Thomas H.

    PY - 2010/11

    Y1 - 2010/11

    N2 - Objective: to identify predictors of non-remission in first-episode, non-affective psychosis. Method: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. Results: One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotid over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n=48), remitted for <6 months (n=38) and for more than 6 months (n=207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks), respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years. Conclusion: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.

    AB - Objective: to identify predictors of non-remission in first-episode, non-affective psychosis. Method: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. Results: One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotid over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n=48), remitted for <6 months (n=38) and for more than 6 months (n=207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks), respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years. Conclusion: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.

    U2 - 10.1111/j.1600-0447.2010.01598.x

    DO - 10.1111/j.1600-0447.2010.01598.x

    M3 - Journal article

    VL - 122

    SP - 375

    EP - 383

    JO - Acta Psychiatrica Scandinavica

    JF - Acta Psychiatrica Scandinavica

    SN - 0001-690X

    IS - 5

    ER -