Early detection of psychosis

positive effects of 5-year outcome

Tor Ketil Larsen, Ingrid Melle, B. Auestad, Ulrik Haahr, Inge Joa, Jan Olav Johannessen, Stein Opjordsmoen, Bjørn Rishovd Rund, Jan Ivar Røssberg, Erik Simonsen, Per Vaglum, Svein Friis, Thomas H. McGlashan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Background During the last decades we have seen a new focus on early treatment of psychosis. Several reviews have shown that duration of untreated psychosis (DUP) is correlated to better outcome. However, it is still unknown whether early treatment will lead to a better long-term outcome. This study reports the effects of reducing DUP on 5-year course and outcome.
    Method During 1997–2000 a total of 281 consecutive patients aged >17 years with first episode non-affective psychosis were recruited, of which 192 participated in the 5-year follow-up. A comprehensive early detection (ED) programme with public information campaigns and low-threshold psychosis detection teams was established in one healthcare area (ED-area), but not in a comparable area (no-ED area). Both areas ran equivalent treatment programmes during the first 2 years and need-adapted treatment thereafter.
    Results At the start of treatment, ED-patients had shorter DUP and less symptoms than no-ED-patients. There were no significant differences in treatment (psychotherapy and medication) for the 5 years. Mixed-effects modelling showed better scores for the ED group on the Positive and Negative Syndrome Scale negative, depressive and cognitive factors and for global assessment of functioning for social functioning at 5-year follow-up. The ED group also had more contacts with friends. Regression analysis did not find that these differences could be explained by confounders.
    Conclusions Early treatment had positive effects on clinical and functional status at 5-year follow-up in first episode psychosis.
    OriginalsprogEngelsk
    TidsskriftPsychological Medicine
    Vol/bind41
    Udgave nummer7
    Sider (fra-til)1461-1469
    Antal sider9
    ISSN0033-2917
    DOI
    StatusUdgivet - 2011

    Citer dette

    Larsen, T. K., Melle, I., Auestad, B., Haahr, U., Joa, I., Johannessen, J. O., ... McGlashan, T. H. (2011). Early detection of psychosis: positive effects of 5-year outcome. Psychological Medicine, 41(7), 1461-1469. https://doi.org/10.1017/S0033291710002023
    Larsen, Tor Ketil ; Melle, Ingrid ; Auestad, B. ; Haahr, Ulrik ; Joa, Inge ; Johannessen, Jan Olav ; Opjordsmoen, Stein ; Rund, Bjørn Rishovd ; Røssberg, Jan Ivar ; Simonsen, Erik ; Vaglum, Per ; Friis, Svein ; McGlashan, Thomas H. / Early detection of psychosis : positive effects of 5-year outcome. I: Psychological Medicine. 2011 ; Bind 41, Nr. 7. s. 1461-1469.
    @article{063b20a023db4a59997f06d42887b824,
    title = "Early detection of psychosis: positive effects of 5-year outcome",
    abstract = "Background During the last decades we have seen a new focus on early treatment of psychosis. Several reviews have shown that duration of untreated psychosis (DUP) is correlated to better outcome. However, it is still unknown whether early treatment will lead to a better long-term outcome. This study reports the effects of reducing DUP on 5-year course and outcome. Method During 1997–2000 a total of 281 consecutive patients aged >17 years with first episode non-affective psychosis were recruited, of which 192 participated in the 5-year follow-up. A comprehensive early detection (ED) programme with public information campaigns and low-threshold psychosis detection teams was established in one healthcare area (ED-area), but not in a comparable area (no-ED area). Both areas ran equivalent treatment programmes during the first 2 years and need-adapted treatment thereafter. Results At the start of treatment, ED-patients had shorter DUP and less symptoms than no-ED-patients. There were no significant differences in treatment (psychotherapy and medication) for the 5 years. Mixed-effects modelling showed better scores for the ED group on the Positive and Negative Syndrome Scale negative, depressive and cognitive factors and for global assessment of functioning for social functioning at 5-year follow-up. The ED group also had more contacts with friends. Regression analysis did not find that these differences could be explained by confounders. Conclusions Early treatment had positive effects on clinical and functional status at 5-year follow-up in first episode psychosis.",
    keywords = "Early intervention, first-episode psychosis, outcome",
    author = "Larsen, {Tor Ketil} and Ingrid Melle and B. Auestad and Ulrik Haahr and Inge Joa and Johannessen, {Jan Olav} and Stein Opjordsmoen and Rund, {Bj{\o}rn Rishovd} and R{\o}ssberg, {Jan Ivar} and Erik Simonsen and Per Vaglum and Svein Friis and McGlashan, {Thomas H.}",
    year = "2011",
    doi = "10.1017/S0033291710002023",
    language = "English",
    volume = "41",
    pages = "1461--1469",
    journal = "Psychological Medicine",
    issn = "0033-2917",
    publisher = "Cambridge University Press",
    number = "7",

    }

    Larsen, TK, Melle, I, Auestad, B, Haahr, U, Joa, I, Johannessen, JO, Opjordsmoen, S, Rund, BR, Røssberg, JI, Simonsen, E, Vaglum, P, Friis, S & McGlashan, TH 2011, 'Early detection of psychosis: positive effects of 5-year outcome', Psychological Medicine, bind 41, nr. 7, s. 1461-1469. https://doi.org/10.1017/S0033291710002023

    Early detection of psychosis : positive effects of 5-year outcome. / Larsen, Tor Ketil; Melle, Ingrid; Auestad, B.; Haahr, Ulrik; Joa, Inge; Johannessen, Jan Olav; Opjordsmoen, Stein; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per; Friis, Svein; McGlashan, Thomas H.

    I: Psychological Medicine, Bind 41, Nr. 7, 2011, s. 1461-1469.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Early detection of psychosis

    T2 - positive effects of 5-year outcome

    AU - Larsen, Tor Ketil

    AU - Melle, Ingrid

    AU - Auestad, B.

    AU - Haahr, Ulrik

    AU - Joa, Inge

    AU - Johannessen, Jan Olav

    AU - Opjordsmoen, Stein

    AU - Rund, Bjørn Rishovd

    AU - Røssberg, Jan Ivar

    AU - Simonsen, Erik

    AU - Vaglum, Per

    AU - Friis, Svein

    AU - McGlashan, Thomas H.

    PY - 2011

    Y1 - 2011

    N2 - Background During the last decades we have seen a new focus on early treatment of psychosis. Several reviews have shown that duration of untreated psychosis (DUP) is correlated to better outcome. However, it is still unknown whether early treatment will lead to a better long-term outcome. This study reports the effects of reducing DUP on 5-year course and outcome. Method During 1997–2000 a total of 281 consecutive patients aged >17 years with first episode non-affective psychosis were recruited, of which 192 participated in the 5-year follow-up. A comprehensive early detection (ED) programme with public information campaigns and low-threshold psychosis detection teams was established in one healthcare area (ED-area), but not in a comparable area (no-ED area). Both areas ran equivalent treatment programmes during the first 2 years and need-adapted treatment thereafter. Results At the start of treatment, ED-patients had shorter DUP and less symptoms than no-ED-patients. There were no significant differences in treatment (psychotherapy and medication) for the 5 years. Mixed-effects modelling showed better scores for the ED group on the Positive and Negative Syndrome Scale negative, depressive and cognitive factors and for global assessment of functioning for social functioning at 5-year follow-up. The ED group also had more contacts with friends. Regression analysis did not find that these differences could be explained by confounders. Conclusions Early treatment had positive effects on clinical and functional status at 5-year follow-up in first episode psychosis.

    AB - Background During the last decades we have seen a new focus on early treatment of psychosis. Several reviews have shown that duration of untreated psychosis (DUP) is correlated to better outcome. However, it is still unknown whether early treatment will lead to a better long-term outcome. This study reports the effects of reducing DUP on 5-year course and outcome. Method During 1997–2000 a total of 281 consecutive patients aged >17 years with first episode non-affective psychosis were recruited, of which 192 participated in the 5-year follow-up. A comprehensive early detection (ED) programme with public information campaigns and low-threshold psychosis detection teams was established in one healthcare area (ED-area), but not in a comparable area (no-ED area). Both areas ran equivalent treatment programmes during the first 2 years and need-adapted treatment thereafter. Results At the start of treatment, ED-patients had shorter DUP and less symptoms than no-ED-patients. There were no significant differences in treatment (psychotherapy and medication) for the 5 years. Mixed-effects modelling showed better scores for the ED group on the Positive and Negative Syndrome Scale negative, depressive and cognitive factors and for global assessment of functioning for social functioning at 5-year follow-up. The ED group also had more contacts with friends. Regression analysis did not find that these differences could be explained by confounders. Conclusions Early treatment had positive effects on clinical and functional status at 5-year follow-up in first episode psychosis.

    KW - Early intervention

    KW - first-episode psychosis

    KW - outcome

    U2 - 10.1017/S0033291710002023

    DO - 10.1017/S0033291710002023

    M3 - Journal article

    VL - 41

    SP - 1461

    EP - 1469

    JO - Psychological Medicine

    JF - Psychological Medicine

    SN - 0033-2917

    IS - 7

    ER -

    Larsen TK, Melle I, Auestad B, Haahr U, Joa I, Johannessen JO et al. Early detection of psychosis: positive effects of 5-year outcome. Psychological Medicine. 2011;41(7):1461-1469. https://doi.org/10.1017/S0033291710002023