Does bisphenol A induce superfeminization in Marisa cornuarietis? Part II: Toxicity test results and requirements for statistical power analyses

Valery E. Forbes, John Aufderheide, Ryan Warbritton, Nelly van der Hoeven, Norbert Caspers

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

This study presents results of the effects of bisphenol A (BPA) on adult egg production, egg hatchability, egg development rates and juvenile growth rates in the freshwater gastropod, Marisa cornuarietis. We observed no adult mortality, substantial inter-snail variability in reproductive output, and no effects of BPA on reproduction during 12 weeks of exposure to 0, 0.1, 1.0, 16, 160 or 640 μg/L BPA. We observed no effects of BPA on egg hatchability or timing of egg hatching. Juveniles showed good growth in the control and all treatments, and there were no significant effects of BPA on this endpoint. Our results do not support previous claims of enhanced reproduction in Marisa cornuarietis in response to exposure to BPA. Statistical power analysis indicated high levels of inter-snail variability in the measured endpoints and highlighted the need for sufficient replication when testing treatment effects on reproduction in M. cornuarietis with adequate power
OriginalsprogEngelsk
TidsskriftEcotoxicology and Environmental Safety
Vol/bind66
Udgave nummer3
Sider (fra-til)319-325
Antal sider7
ISSN0147-6513
DOI
StatusUdgivet - 2007

Emneord

    Citer dette

    Forbes, Valery E. ; Aufderheide, John ; Warbritton, Ryan ; van der Hoeven, Nelly ; Caspers, Norbert. / Does bisphenol A induce superfeminization in Marisa cornuarietis? Part II : Toxicity test results and requirements for statistical power analyses. I: Ecotoxicology and Environmental Safety. 2007 ; Bind 66, Nr. 3. s. 319-325.
    @article{e97e541070ee11dc89fc000ea68e967b,
    title = "Does bisphenol A induce superfeminization in Marisa cornuarietis? Part II: Toxicity test results and requirements for statistical power analyses",
    abstract = "This study presents results of the effects of bisphenol A (BPA) on adult egg production, egg hatchability, egg development rates and juvenile growth rates in the freshwater gastropod, Marisa cornuarietis. We observed no adult mortality, substantial inter-snail variability in reproductive output, and no effects of BPA on reproduction during 12 weeks of exposure to 0, 0.1, 1.0, 16, 160 or 640 μg/L BPA. We observed no effects of BPA on egg hatchability or timing of egg hatching. Juveniles showed good growth in the control and all treatments, and there were no significant effects of BPA on this endpoint. Our results do not support previous claims of enhanced reproduction in Marisa cornuarietis in response to exposure to BPA. Statistical power analysis indicated high levels of inter-snail variability in the measured endpoints and highlighted the need for sufficient replication when testing treatment effects on reproduction in M. cornuarietis with adequate power",
    keywords = "Endocrine disruption, Low-dose effects, Reproduction, Risk assessment, Statistical power, Variability",
    author = "Forbes, {Valery E.} and John Aufderheide and Ryan Warbritton and {van der Hoeven}, Nelly and Norbert Caspers",
    year = "2007",
    doi = "doi:10.1016/j.ecoenv.2006.09.001",
    language = "English",
    volume = "66",
    pages = "319--325",
    journal = "Ecotoxicology and Environmental Safety",
    issn = "0147-6513",
    publisher = "Academic Press",
    number = "3",

    }

    Does bisphenol A induce superfeminization in Marisa cornuarietis? Part II : Toxicity test results and requirements for statistical power analyses. / Forbes, Valery E.; Aufderheide, John; Warbritton, Ryan; van der Hoeven, Nelly; Caspers, Norbert.

    I: Ecotoxicology and Environmental Safety, Bind 66, Nr. 3, 2007, s. 319-325.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Does bisphenol A induce superfeminization in Marisa cornuarietis? Part II

    T2 - Toxicity test results and requirements for statistical power analyses

    AU - Forbes, Valery E.

    AU - Aufderheide, John

    AU - Warbritton, Ryan

    AU - van der Hoeven, Nelly

    AU - Caspers, Norbert

    PY - 2007

    Y1 - 2007

    N2 - This study presents results of the effects of bisphenol A (BPA) on adult egg production, egg hatchability, egg development rates and juvenile growth rates in the freshwater gastropod, Marisa cornuarietis. We observed no adult mortality, substantial inter-snail variability in reproductive output, and no effects of BPA on reproduction during 12 weeks of exposure to 0, 0.1, 1.0, 16, 160 or 640 μg/L BPA. We observed no effects of BPA on egg hatchability or timing of egg hatching. Juveniles showed good growth in the control and all treatments, and there were no significant effects of BPA on this endpoint. Our results do not support previous claims of enhanced reproduction in Marisa cornuarietis in response to exposure to BPA. Statistical power analysis indicated high levels of inter-snail variability in the measured endpoints and highlighted the need for sufficient replication when testing treatment effects on reproduction in M. cornuarietis with adequate power

    AB - This study presents results of the effects of bisphenol A (BPA) on adult egg production, egg hatchability, egg development rates and juvenile growth rates in the freshwater gastropod, Marisa cornuarietis. We observed no adult mortality, substantial inter-snail variability in reproductive output, and no effects of BPA on reproduction during 12 weeks of exposure to 0, 0.1, 1.0, 16, 160 or 640 μg/L BPA. We observed no effects of BPA on egg hatchability or timing of egg hatching. Juveniles showed good growth in the control and all treatments, and there were no significant effects of BPA on this endpoint. Our results do not support previous claims of enhanced reproduction in Marisa cornuarietis in response to exposure to BPA. Statistical power analysis indicated high levels of inter-snail variability in the measured endpoints and highlighted the need for sufficient replication when testing treatment effects on reproduction in M. cornuarietis with adequate power

    KW - Endocrine disruption

    KW - Low-dose effects

    KW - Reproduction

    KW - Risk assessment

    KW - Statistical power

    KW - Variability

    U2 - doi:10.1016/j.ecoenv.2006.09.001

    DO - doi:10.1016/j.ecoenv.2006.09.001

    M3 - Journal article

    VL - 66

    SP - 319

    EP - 325

    JO - Ecotoxicology and Environmental Safety

    JF - Ecotoxicology and Environmental Safety

    SN - 0147-6513

    IS - 3

    ER -