DNA damage, acetylcholinesterase activity and lysosomal stability in native and transplanted mussels (Mytilus edulis) in areas close to coastal chemical dumping sites in Denmark

Jette Rank, Kari K. Lehtonen, Jakob Strand, Martha Laursen

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Resumé

Biomarkers of genotoxicity (DNA damage, measured as tail moment in the Comet assay), neurotoxicity (acetylcholinesterase inhibition, AChE) and general stress (lysosomal membrane stability, LMS) were studied in native and transplanted blue mussels (Mytilus edulis) in coastal areas of western Denmark potentially affected by anthropogenic pollution originating from chemical dumping sites. The results indicate responses to pollution in all the biomarkers applied at the suspected areas, but the results were not consistent. Seasonal fluctuations in exposure situations at the study sites make interpretation of chemical pollution complex, as seen especially in the variability in results on DNA damage, and also in regard to AChE activity. These investigations further stress the importance of understanding the effects of natural factors (salinity, temperature, water levels, rain and storm events) in correct interpretation of the biomarker data obtained. In addition, adaptation of populations to local contamination may play a role in some of the response patterns observed. © 2007 Elsevier B.V. All rights reserved

OriginalsprogEngelsk
TidsskriftAquatic Toxicology
Vol/bind84
Udgave nummer1
Sider (fra-til)50-61
Antal sider10
ISSN0166-445X
DOI
StatusUdgivet - 2007

Citer dette

@article{a8c8853014d711dc9ac4000ea68e967b,
title = "DNA damage, acetylcholinesterase activity and lysosomal stability in native and transplanted mussels (Mytilus edulis) in areas close to coastal chemical dumping sites in Denmark",
abstract = "Biomarkers of genotoxicity (DNA damage, measured as tail moment in the Comet assay), neurotoxicity (acetylcholinesterase inhibition, AChE) and general stress (lysosomal membrane stability, LMS) were studied in native and transplanted blue mussels (Mytilus edulis) in coastal areas of western Denmark potentially affected by anthropogenic pollution originating from chemical dumping sites. The results indicate responses to pollution in all the biomarkers applied at the suspected areas, but the results were not consistent. Seasonal fluctuations in exposure situations at the study sites make interpretation of chemical pollution complex, as seen especially in the variability in results on DNA damage, and also in regard to AChE activity. These investigations further stress the importance of understanding the effects of natural factors (salinity, temperature, water levels, rain and storm events) in correct interpretation of the biomarker data obtained. In addition, adaptation of populations to local contamination may play a role in some of the response patterns observed. {\circledC} 2007 Elsevier B.V. All rights reserved",
keywords = "DNA damage, Comet assay, Acetylcholinesterase activity, Lysosomal membrane stability, Biomarker, Pollution monitoring, Blue mussel, Mytilus edulis",
author = "Jette Rank and Lehtonen, {Kari K.} and Jakob Strand and Martha Laursen",
year = "2007",
doi = "10.1016/j.aquatox.2007.05.013",
language = "English",
volume = "84",
pages = "50--61",
journal = "Aquatic Toxicology",
issn = "0166-445X",
publisher = "Elsevier BV",
number = "1",

}

DNA damage, acetylcholinesterase activity and lysosomal stability in native and transplanted mussels (Mytilus edulis) in areas close to coastal chemical dumping sites in Denmark. / Rank, Jette; Lehtonen, Kari K.; Strand, Jakob; Laursen, Martha.

I: Aquatic Toxicology, Bind 84, Nr. 1, 2007, s. 50-61.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - DNA damage, acetylcholinesterase activity and lysosomal stability in native and transplanted mussels (Mytilus edulis) in areas close to coastal chemical dumping sites in Denmark

AU - Rank, Jette

AU - Lehtonen, Kari K.

AU - Strand, Jakob

AU - Laursen, Martha

PY - 2007

Y1 - 2007

N2 - Biomarkers of genotoxicity (DNA damage, measured as tail moment in the Comet assay), neurotoxicity (acetylcholinesterase inhibition, AChE) and general stress (lysosomal membrane stability, LMS) were studied in native and transplanted blue mussels (Mytilus edulis) in coastal areas of western Denmark potentially affected by anthropogenic pollution originating from chemical dumping sites. The results indicate responses to pollution in all the biomarkers applied at the suspected areas, but the results were not consistent. Seasonal fluctuations in exposure situations at the study sites make interpretation of chemical pollution complex, as seen especially in the variability in results on DNA damage, and also in regard to AChE activity. These investigations further stress the importance of understanding the effects of natural factors (salinity, temperature, water levels, rain and storm events) in correct interpretation of the biomarker data obtained. In addition, adaptation of populations to local contamination may play a role in some of the response patterns observed. © 2007 Elsevier B.V. All rights reserved

AB - Biomarkers of genotoxicity (DNA damage, measured as tail moment in the Comet assay), neurotoxicity (acetylcholinesterase inhibition, AChE) and general stress (lysosomal membrane stability, LMS) were studied in native and transplanted blue mussels (Mytilus edulis) in coastal areas of western Denmark potentially affected by anthropogenic pollution originating from chemical dumping sites. The results indicate responses to pollution in all the biomarkers applied at the suspected areas, but the results were not consistent. Seasonal fluctuations in exposure situations at the study sites make interpretation of chemical pollution complex, as seen especially in the variability in results on DNA damage, and also in regard to AChE activity. These investigations further stress the importance of understanding the effects of natural factors (salinity, temperature, water levels, rain and storm events) in correct interpretation of the biomarker data obtained. In addition, adaptation of populations to local contamination may play a role in some of the response patterns observed. © 2007 Elsevier B.V. All rights reserved

KW - DNA damage

KW - Comet assay

KW - Acetylcholinesterase activity

KW - Lysosomal membrane stability

KW - Biomarker

KW - Pollution monitoring

KW - Blue mussel

KW - Mytilus edulis

U2 - 10.1016/j.aquatox.2007.05.013

DO - 10.1016/j.aquatox.2007.05.013

M3 - Journal article

VL - 84

SP - 50

EP - 61

JO - Aquatic Toxicology

JF - Aquatic Toxicology

SN - 0166-445X

IS - 1

ER -