Development of patient specific cardiovascular models predicting dynamics in response to orthostatic stress challenges

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Abstract

Physiological realistic models of the controlled cardiovascular system
are constructed and validated against clinical data. Special attention is paid
to the control of blood pressure, cerebral blood flow velocity, and heart
rate during postural challenges, including sit-to-stand and head-up tilt. This
study describes development of patient specific models, and how sensitivity
analysis and nonlinear optimization methods can be used to predict patient
specific characteristics when analyzed using experimental data. Finally, we
discuss how a given model can be used to understand physiological changes
between groups of individuals and how to use modeling to identify biomarkers
OriginalsprogEngelsk
TitelMathematical Modeling and Validation in Physiology : Applications to the cardiovascular and respiratory systems
RedaktørerJerry Batzel, Mostafa Bachar, Franz Kappel
Antal sider37
Udgivelses stedHedelberg
ForlagSpringer
Publikationsdato2013
Sider177-214
Kapitel10
ISBN (Trykt)978-3-642-32881-7
ISBN (Elektronisk)978-3-642-32882-4
DOI
StatusUdgivet - 2013
NavnLecture Notes in Mathematics
Vol/bind2064
ISSN0075-8434

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