Developing an ELISA using serotype-specific antigens from selected pneumococcal strains of own selection

H. C. Slotved*, J. N. Jacobsen, H. K. Møller, K. A. Krogfelt

*Corresponding author

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Streptococcus pneumoniae (pneumococcus) is a significant cause of morbidity and mortality in infants and elderly people. Pneumococcal strains possess a polysaccharide capsule, and 90 different serotypes have been identified. The pneumococcal ELISA suggested by World Health Organization (WHO) guidelines is based on capsular serotypes included in the 23-valent polysaccharide vaccine (Pneumovax®). Pneumococcal antigens were developed and applied in an ELISA, which elicited a low baseline cross-reaction with the common cell wall polysaccharide (C-Ps). The aim of this study was to develop an ELISA using type-specific antigens from S. pneumoniae strains with serotypes of own selection in order to quantify type-specific pneumococcal antibodies in human serum.

Udgave nummer13
Sider (fra-til)2513-2517
Antal sider5
StatusUdgivet - 22 mar. 2007
Udgivet eksterntJa

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