Developement of patient specific cardiovascular models predicting dynamics in response to orthostatic challanges

Johnny T. Ottesen, Vera Novak, Mette Olufsen

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskning

Abstract

Physiological realistic models of the controlled cardiovascular system
are constructed and validated against clinical data. Special attention is paid
to the control of blood pressure, cerebral blood flow velocity, and heart
rate during postural challenges, including sit-to-stand and head-up tilt. This
study describes development of patient specific models, and how sensitivity
analysis and nonlinear optimization methods can be used to predict patient
specific characteristics when analyzed using experimental data. Finally, we
discuss how a given model can be used to understand physiological changes
between groups of individuals and how to use modeling to identify biomarkers.
OriginalsprogEngelsk
Titelproceedings in the Springer Lecture Notes in Mathematics (LNM) series on Biosciences
Antal sider45
ForlagSpringer
Publikationsdato2011
Kapitel9
StatusUdgivet - 2011
Udgivet eksterntJa

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