Cytotoxic geranylated xanthones and O-alkylated derivatives of alpha-mangostin

Ly Dieu Ha, Poul Erik Hansen, Ole Vang, Fritz Duus, Hung Dinh Pham, Lien-Hoa Dieu Nguyen

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Two new geranylated xanthones, 6-O-methylcowanin (4) and oliverixanthone (5), along with five known
compounds, cowanin, rubraxanthone, cowaxanthone, cowanol, and β-mangostin, have been isolated from the
bark of Garcinia oliveri. For comparison of their biological activities, one mono- and seven di-O-alkylated
α-mangostin derivatives were synthesized from α-mangostin. The structures of all compounds were assigned by
spectroscopic methods (1D and 2D NMR and MS). Cytotoxicity of selected xanthones against MCF-7 and DLD-1
cell lines was examined. Evaluation of the structure–activity relationship showed that α-mangostin had the
strongest activity, and all the O-alkylated α-mangostin derivatives showed reduced activity compared to the naturally
occurring α-mangostin.
TidsskriftChemical & Pharmaceutical Bulletin
Udgave nummer8
Sider (fra-til)830-834
Antal sider5
StatusUdgivet - 2009

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