Resumé
Information about the cost-effectiveness of early intervention programmes for first-episode psychosis is limited.
Aims
To evaluate the cost-effectiveness of an intensive early-intervention programme (called OPUS) (trial registration NCT00157313) consisting of enriched assertive community treatment, psychoeducational family treatment and social skills training for individuals with first-episode psychosis compared with standard treatment.
Method
An incremental cost-effectiveness analysis of a randomised controlled trial, adopting a public sector perspective was undertaken.
Results
The mean total costs of OPUS over 5 years (€123 683, s.e. = 8970) were not significantly different from that of standard treatment (€148 751, s.e. = 13073). At 2-year follow-up the mean Global Assessment of Functioning (GAF) score in the OPUS group (55.16, s.d. = 15.15) was significantly higher than in standard treatment group (51.13, s.d. = 15.92). However, the mean GAF did not differ significantly between the groups at 5-year follow-up (55.35 (s.d. = 18.28) and 54.16 (s.d. = 18.41), respectively). Cost-effectiveness planes based on non-parametric bootstrapping showed that OPUS was less costly and more effective in 70% of the replications. For a willingness-to-pay up to €50 000 the probability that OPUS was cost-effective was more than 80%.
Conclusions
The incremental cost-effectiveness analysis showed that there was a high probability of OPUS being cost-effective compared with standard treatment.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | British Journal of Psychiatry |
| Vol/bind | 202 |
| Udgave nummer | 1 |
| Sider (fra-til) | 35-41 |
| ISSN | 0007-1250 |
| DOI | |
| Status | Udgivet - 2013 |
Citer dette
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Cost-effectiveness of early intervention in first-episode psychosis : economic evaluation of a randomised controlled trial (the OPUS study). / Hastrup, Lene Halling; Kronborg, C; Bertelsen, M; Jeppesen, P; Jørgensen, P; Petersen, L; Thorup, A; Simonsen, Erik; Nordentoft, Merete.
I: British Journal of Psychiatry, Bind 202, Nr. 1, 2013, s. 35-41.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Cost-effectiveness of early intervention in first-episode psychosis
T2 - economic evaluation of a randomised controlled trial (the OPUS study)
AU - Hastrup, Lene Halling
AU - Kronborg, C
AU - Bertelsen, M
AU - Jeppesen, P
AU - Jørgensen, P
AU - Petersen, L
AU - Thorup, A
AU - Simonsen, Erik
AU - Nordentoft, Merete
PY - 2013
Y1 - 2013
N2 - BackgroundInformation about the cost-effectiveness of early intervention programmes for first-episode psychosis is limited.AimsTo evaluate the cost-effectiveness of an intensive early-intervention programme (called OPUS) (trial registration NCT00157313) consisting of enriched assertive community treatment, psychoeducational family treatment and social skills training for individuals with first-episode psychosis compared with standard treatment. MethodAn incremental cost-effectiveness analysis of a randomised controlled trial, adopting a public sector perspective was undertaken.ResultsThe mean total costs of OPUS over 5 years (€123 683, s.e. = 8970) were not significantly different from that of standard treatment (€148 751, s.e. = 13073). At 2-year follow-up the mean Global Assessment of Functioning (GAF) score in the OPUS group (55.16, s.d. = 15.15) was significantly higher than in standard treatment group (51.13, s.d. = 15.92). However, the mean GAF did not differ significantly between the groups at 5-year follow-up (55.35 (s.d. = 18.28) and 54.16 (s.d. = 18.41), respectively). Cost-effectiveness planes based on non-parametric bootstrapping showed that OPUS was less costly and more effective in 70% of the replications. For a willingness-to-pay up to €50 000 the probability that OPUS was cost-effective was more than 80%. ConclusionsThe incremental cost-effectiveness analysis showed that there was a high probability of OPUS being cost-effective compared with standard treatment.
AB - BackgroundInformation about the cost-effectiveness of early intervention programmes for first-episode psychosis is limited.AimsTo evaluate the cost-effectiveness of an intensive early-intervention programme (called OPUS) (trial registration NCT00157313) consisting of enriched assertive community treatment, psychoeducational family treatment and social skills training for individuals with first-episode psychosis compared with standard treatment. MethodAn incremental cost-effectiveness analysis of a randomised controlled trial, adopting a public sector perspective was undertaken.ResultsThe mean total costs of OPUS over 5 years (€123 683, s.e. = 8970) were not significantly different from that of standard treatment (€148 751, s.e. = 13073). At 2-year follow-up the mean Global Assessment of Functioning (GAF) score in the OPUS group (55.16, s.d. = 15.15) was significantly higher than in standard treatment group (51.13, s.d. = 15.92). However, the mean GAF did not differ significantly between the groups at 5-year follow-up (55.35 (s.d. = 18.28) and 54.16 (s.d. = 18.41), respectively). Cost-effectiveness planes based on non-parametric bootstrapping showed that OPUS was less costly and more effective in 70% of the replications. For a willingness-to-pay up to €50 000 the probability that OPUS was cost-effective was more than 80%. ConclusionsThe incremental cost-effectiveness analysis showed that there was a high probability of OPUS being cost-effective compared with standard treatment.
U2 - 10.1192/bjp.bp.112.112300
DO - 10.1192/bjp.bp.112.112300
M3 - Journal article
VL - 202
SP - 35
EP - 41
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - 1
ER -