Complete genome sequence of the myxobacterium Sorangium cellulosum.

S Schneiker, O Perlova, O kaiser, K Gerth, A Alici, MO Altmeyer, D Bartels, T Bekel, S Beyer, E Bode, HB Bode, CJ Bolten, JV Choudhuri, S Doss, YA Elnakady, B Frank, L Gaigalat, A Goesmann, C Groeger, F Gross & 38 andre Lars Jelsbak, Lotte Jelsbak, J Kalinowski, C Kegler, T Knauber, S Konietzny, M Kopp, L Krause, D krug, B Linke, T Mahmud, R Martinez-Arias, AC McHardy, M Merai, F Meyer, S Mormann, J Munoz-Dorado, J Perez, S Pradella, S Rachid, G Raddatz, F Rosenau, C Ruckert, F Sasse, M Scharfe, SC Schuster, G Suen, A Treuner-Lange, GJ Velicer, FJ Vorholter, KJ Weissman, RD Welch, DE Whitworth, S Wilhelm, C Wittmann, H Blocker, A Puhler, R Muller

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.
OriginalsprogEngelsk
TidsskriftNature Biotechnology
ISSN1087-0156
StatusUdgivet - 2007
Udgivet eksterntJa

Citer dette

Schneiker, S., Perlova, O., kaiser, O., Gerth, K., Alici, A., Altmeyer, MO., ... Muller, R. (2007). Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology.
Schneiker, S ; Perlova, O ; kaiser, O ; Gerth, K ; Alici, A ; Altmeyer, MO ; Bartels, D ; Bekel, T ; Beyer, S ; Bode, E ; Bode, HB ; Bolten, CJ ; Choudhuri, JV ; Doss, S ; Elnakady, YA ; Frank, B ; Gaigalat, L ; Goesmann, A ; Groeger, C ; Gross, F ; Jelsbak, Lars ; Jelsbak, Lotte ; Kalinowski, J ; Kegler, C ; Knauber, T ; Konietzny, S ; Kopp, M ; Krause, L ; krug, D ; Linke, B ; Mahmud, T ; Martinez-Arias, R ; McHardy, AC ; Merai, M ; Meyer, F ; Mormann, S ; Munoz-Dorado, J ; Perez, J ; Pradella, S ; Rachid, S ; Raddatz, G ; Rosenau, F ; Ruckert, C ; Sasse, F ; Scharfe, M ; Schuster, SC ; Suen, G ; Treuner-Lange, A ; Velicer, GJ ; Vorholter, FJ ; Weissman, KJ ; Welch, RD ; Whitworth, DE ; Wilhelm, S ; Wittmann, C ; Blocker, H ; Puhler, A ; Muller, R. / Complete genome sequence of the myxobacterium Sorangium cellulosum. I: Nature Biotechnology. 2007.
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title = "Complete genome sequence of the myxobacterium Sorangium cellulosum.",
abstract = "The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.",
author = "S Schneiker and O Perlova and O kaiser and K Gerth and A Alici and MO Altmeyer and D Bartels and T Bekel and S Beyer and E Bode and HB Bode and CJ Bolten and JV Choudhuri and S Doss and YA Elnakady and B Frank and L Gaigalat and A Goesmann and C Groeger and F Gross and Lars Jelsbak and Lotte Jelsbak and J Kalinowski and C Kegler and T Knauber and S Konietzny and M Kopp and L Krause and D krug and B Linke and T Mahmud and R Martinez-Arias and AC McHardy and M Merai and F Meyer and S Mormann and J Munoz-Dorado and J Perez and S Pradella and S Rachid and G Raddatz and F Rosenau and C Ruckert and F Sasse and M Scharfe and SC Schuster and G Suen and A Treuner-Lange and GJ Velicer and FJ Vorholter and KJ Weissman and RD Welch and DE Whitworth and S Wilhelm and C Wittmann and H Blocker and A Puhler and R Muller",
year = "2007",
language = "English",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",

}

Schneiker, S, Perlova, O, kaiser, O, Gerth, K, Alici, A, Altmeyer, MO, Bartels, D, Bekel, T, Beyer, S, Bode, E, Bode, HB, Bolten, CJ, Choudhuri, JV, Doss, S, Elnakady, YA, Frank, B, Gaigalat, L, Goesmann, A, Groeger, C, Gross, F, Jelsbak, L, Jelsbak, L, Kalinowski, J, Kegler, C, Knauber, T, Konietzny, S, Kopp, M, Krause, L, krug, D, Linke, B, Mahmud, T, Martinez-Arias, R, McHardy, AC, Merai, M, Meyer, F, Mormann, S, Munoz-Dorado, J, Perez, J, Pradella, S, Rachid, S, Raddatz, G, Rosenau, F, Ruckert, C, Sasse, F, Scharfe, M, Schuster, SC, Suen, G, Treuner-Lange, A, Velicer, GJ, Vorholter, FJ, Weissman, KJ, Welch, RD, Whitworth, DE, Wilhelm, S, Wittmann, C, Blocker, H, Puhler, A & Muller, R 2007, 'Complete genome sequence of the myxobacterium Sorangium cellulosum.', Nature Biotechnology.

Complete genome sequence of the myxobacterium Sorangium cellulosum. / Schneiker, S; Perlova, O; kaiser, O; Gerth, K; Alici, A; Altmeyer, MO; Bartels, D; Bekel, T; Beyer, S; Bode, E; Bode, HB; Bolten, CJ; Choudhuri, JV; Doss, S; Elnakady, YA; Frank, B; Gaigalat, L; Goesmann, A; Groeger, C; Gross, F; Jelsbak, Lars; Jelsbak, Lotte; Kalinowski, J; Kegler, C; Knauber, T; Konietzny, S; Kopp, M; Krause, L; krug, D; Linke, B; Mahmud, T; Martinez-Arias, R; McHardy, AC; Merai, M; Meyer, F; Mormann, S; Munoz-Dorado, J; Perez, J; Pradella, S; Rachid, S; Raddatz, G; Rosenau, F; Ruckert, C; Sasse, F; Scharfe, M; Schuster, SC; Suen, G; Treuner-Lange, A; Velicer, GJ; Vorholter, FJ; Weissman, KJ; Welch, RD; Whitworth, DE; Wilhelm, S; Wittmann, C; Blocker, H; Puhler, A; Muller, R.

I: Nature Biotechnology, 2007.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Complete genome sequence of the myxobacterium Sorangium cellulosum.

AU - Schneiker, S

AU - Perlova, O

AU - kaiser, O

AU - Gerth, K

AU - Alici, A

AU - Altmeyer, MO

AU - Bartels, D

AU - Bekel, T

AU - Beyer, S

AU - Bode, E

AU - Bode, HB

AU - Bolten, CJ

AU - Choudhuri, JV

AU - Doss, S

AU - Elnakady, YA

AU - Frank, B

AU - Gaigalat, L

AU - Goesmann, A

AU - Groeger, C

AU - Gross, F

AU - Jelsbak, Lars

AU - Jelsbak, Lotte

AU - Kalinowski, J

AU - Kegler, C

AU - Knauber, T

AU - Konietzny, S

AU - Kopp, M

AU - Krause, L

AU - krug, D

AU - Linke, B

AU - Mahmud, T

AU - Martinez-Arias, R

AU - McHardy, AC

AU - Merai, M

AU - Meyer, F

AU - Mormann, S

AU - Munoz-Dorado, J

AU - Perez, J

AU - Pradella, S

AU - Rachid, S

AU - Raddatz, G

AU - Rosenau, F

AU - Ruckert, C

AU - Sasse, F

AU - Scharfe, M

AU - Schuster, SC

AU - Suen, G

AU - Treuner-Lange, A

AU - Velicer, GJ

AU - Vorholter, FJ

AU - Weissman, KJ

AU - Welch, RD

AU - Whitworth, DE

AU - Wilhelm, S

AU - Wittmann, C

AU - Blocker, H

AU - Puhler, A

AU - Muller, R

PY - 2007

Y1 - 2007

N2 - The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.

AB - The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.

M3 - Journal article

JO - Nature Biotechnology

JF - Nature Biotechnology

SN - 1087-0156

ER -

Schneiker S, Perlova O, kaiser O, Gerth K, Alici A, Altmeyer MO et al. Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology. 2007.