Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer

Maiken Lise Marcker Espersen, Jesper Olsen, Dorte Linnemann, Estrid Høgdall, Jesper Troelsen

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Resumé

    Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell–specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance
    OriginalsprogDansk
    TidsskriftClinical Colorectal Cancer
    Vol/bind14
    Udgave nummer2
    Sider (fra-til)63-71
    ISSN1533-0028
    DOI
    StatusUdgivet - 2015

    Citer dette

    Espersen, Maiken Lise Marcker ; Olsen, Jesper ; Linnemann, Dorte ; Høgdall, Estrid ; Troelsen, Jesper. / Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer. I: Clinical Colorectal Cancer. 2015 ; Bind 14, Nr. 2. s. 63-71.
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    title = "Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer",
    abstract = "Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell–specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance",
    author = "Espersen, {Maiken Lise Marcker} and Jesper Olsen and Dorte Linnemann and Estrid H{\o}gdall and Jesper Troelsen",
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    Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer. / Espersen, Maiken Lise Marcker; Olsen, Jesper; Linnemann, Dorte; Høgdall, Estrid; Troelsen, Jesper.

    I: Clinical Colorectal Cancer, Bind 14, Nr. 2, 2015, s. 63-71.

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    TY - JOUR

    T1 - Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer

    AU - Espersen, Maiken Lise Marcker

    AU - Olsen, Jesper

    AU - Linnemann, Dorte

    AU - Høgdall, Estrid

    AU - Troelsen, Jesper

    PY - 2015

    Y1 - 2015

    N2 - Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell–specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance

    AB - Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell–specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance

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    DO - 10.1016/j.clcc.2014.12.004

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    VL - 14

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    JO - Clinical Colorectal Cancer

    JF - Clinical Colorectal Cancer

    SN - 1533-0028

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    ER -