Circulating micro-RNAs Differentially Expressed in Korean Alzheimer’s Patients With Brain Aβ Accumulation Activate Amyloidogenesis

Sakulrat  Mankhong; Sujin Kim; Sohee Moon; Seong-Hye  Choi; Hyo-Bum  Kwak; Dong-Ho  Park; Pratik Shah; Phil Hyu  Lee; Seong Wook Yang; Ju-Hee Kang

doi:10.1093/gerona/glac106

Circulating micro-RNAs Differentially Expressed in Korean Alzheimer’s Patients With Brain Aβ Accumulation Activate Amyloidogenesis

Sakulrat Mankhong, Sujin Kim, Sohee Moon, Seong-Hye Choi , Hyo-Bum Kwak, Dong-Ho Park, Pratik Shah, Phil Hyu Lee^*, Seong Wook Yang, Ju-Hee Kang^*

^*Corresponding author

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

A role for extracellular vesicles (EVs) enriched with micro-RNAs (miRNAs) has been proposed in Alzheimer’s disease (AD) pathogenesis, leading to the discovery of blood miRNAs as biomarkers of AD. However, the diagnostic utility of speci c miRNAs is not consistent. This study aimed to discover blood miRNAs that are differentially expressed in Korean AD patients, evaluate their clinical performance in plasma or plasma EVs, and investigate their role in amyloidogenesis.

Originalsprog	Engelsk
Tidsskrift	The Journals of Gerontology: Series A
Vol/bind	78
Udgave nummer	2
Sider (fra-til)	292-303
Antal sider	12
ISSN	1758-535X
DOI	https://doi.org/10.1093/gerona/glac106
Status	Udgivet - feb. 2023
Udgivet eksternt	Ja

Emneord

microRNA
Alzheimer's disease
Diagnostics
Beta-amyloid
Extracellular vesicle
Blood biomarkers

Link til dokument

10.1093/gerona/glac106

Circulating micro-RNAs Differentially Expressed in Korean Alzheimer’s Patients with Brain Aβ Accumulation Activate AmyloidogenesisIndsendt manuskript, 2,84 MBLicens: CC BY

Citer dette

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abstract = "A role for extracellular vesicles (EVs) enriched with micro-RNAs (miRNAs) has been proposed in Alzheimer{\textquoteright}s disease (AD) pathogenesis, leading to the discovery of blood miRNAs as biomarkers of AD. However, the diagnostic utility of speci c miRNAs is not consistent. This study aimed to discover blood miRNAs that are differentially expressed in Korean AD patients, evaluate their clinical performance in plasma or plasma EVs, and investigate their role in amyloidogenesis.",

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AU - Kim, Sujin

AU - Moon, Sohee

AU - Choi , Seong-Hye

AU - Kwak, Hyo-Bum

AU - Park, Dong-Ho

AU - Shah, Pratik

AU - Lee, Phil Hyu

AU - Yang, Seong Wook

AU - Kang, Ju-Hee

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KW - Alzheimer's disease

KW - Diagnostics

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KW - Extracellular vesicle

KW - Blood biomarkers

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KW - Alzheimer's disease

KW - Diagnostics

KW - Extracellular vesicle

KW - Beta-amyloid

KW - Blood biomarkers

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JF - The Journals of Gerontology: Series A

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