Chelation therapy in intoxications with mercury, lead and copper

yang Cao, Marit Aralt Skaug, Ole Andersen, Jan Aaseth

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstract

    In the present review we provide an update of the appropriate use of chelating agents in the treatment of intoxications with compounds of mercury, lead and copper. The relatively new chelators meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS) can effectively mobilize deposits of mercury as well as of lead into the urine. These drugs can be administered orally and have relatively low toxicity compared to the classical antidote dimercaptopropanol (BAL). d-Penicillamine has been widely used in copper overload, although 2,3-dimercaptosuccinic acid or tetrathiomolybdate may be more suitable alternatives today. In copper-toxicity, a free radical scavenger might be recommended as adjuvant to the chelator therapy
    OriginalsprogEngelsk
    TidsskriftJournal of Trace Elements in Medicine and Biology
    Vol/bind31
    Sider (fra-til)188-192
    ISSN0946-672X
    DOI
    StatusUdgivet - 2015

    Bibliografisk note

    Special Section: 10th Nordic Symposium on Trace Elements in Human Health and Disease, edited by Jan Aaseth

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