Characterization and Micellization of a Poloxamer Block Copolymer

Søren Hvidt, Walther Batsberg

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Several poloxamers that are symmetrical EPE block copolymers (E and P are ethylene and propylene oxide, respectively) have been characterized by size exclusion chromatography on Superose columns in water. The poloxamers contain between 12 and 26 wt% of smaller-size UV-absorbing impurities. Poloxamer P94 (E28P48E28) forms micelles with increasing temperature, and micellization was investigated by eluent gel permeation chromatography (EGPC). EGPC results demonstrate that P94 impurities are not incorporated into the micelles up to 38°C. The importance of poloxamer heterogeneity for thermodynamic and structural studies is discussed.
OriginalsprogEngelsk
TidsskriftInternational Journal of Polymer Analysis & Characterization
Vol/bind12
Udgave nummer1
Sider (fra-til)13-22
Antal sider10
ISSN1023-666X
DOI
StatusUdgivet - 2007

Citer dette

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Characterization and Micellization of a Poloxamer Block Copolymer. / Hvidt, Søren; Batsberg, Walther.

I: International Journal of Polymer Analysis & Characterization, Bind 12, Nr. 1, 2007, s. 13-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Characterization and Micellization of a Poloxamer Block Copolymer

AU - Hvidt, Søren

AU - Batsberg, Walther

PY - 2007

Y1 - 2007

N2 - Several poloxamers that are symmetrical EPE block copolymers (E and P are ethylene and propylene oxide, respectively) have been characterized by size exclusion chromatography on Superose columns in water. The poloxamers contain between 12 and 26 wt% of smaller-size UV-absorbing impurities. Poloxamer P94 (E28P48E28) forms micelles with increasing temperature, and micellization was investigated by eluent gel permeation chromatography (EGPC). EGPC results demonstrate that P94 impurities are not incorporated into the micelles up to 38°C. The importance of poloxamer heterogeneity for thermodynamic and structural studies is discussed.

AB - Several poloxamers that are symmetrical EPE block copolymers (E and P are ethylene and propylene oxide, respectively) have been characterized by size exclusion chromatography on Superose columns in water. The poloxamers contain between 12 and 26 wt% of smaller-size UV-absorbing impurities. Poloxamer P94 (E28P48E28) forms micelles with increasing temperature, and micellization was investigated by eluent gel permeation chromatography (EGPC). EGPC results demonstrate that P94 impurities are not incorporated into the micelles up to 38°C. The importance of poloxamer heterogeneity for thermodynamic and structural studies is discussed.

U2 - 10.1080/10236660601094093

DO - 10.1080/10236660601094093

M3 - Journal article

VL - 12

SP - 13

EP - 22

JO - International Journal of Polymer Analysis & Characterization

JF - International Journal of Polymer Analysis & Characterization

SN - 1023-666X

IS - 1

ER -