Characterization and Micellization of a Poloxamer Block Copolymer

Søren Hvidt, Walther Batsberg

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Several poloxamers that are symmetrical EPE block copolymers (E and P are ethylene and propylene oxide, respectively) have been characterized by size exclusion chromatography on Superose columns in water. The poloxamers contain between 12 and 26 wt% of smaller-size UV-absorbing impurities. Poloxamer P94 (E28P48E28) forms micelles with increasing temperature, and micellization was investigated by eluent gel permeation chromatography (EGPC). EGPC results demonstrate that P94 impurities are not incorporated into the micelles up to 38°C. The importance of poloxamer heterogeneity for thermodynamic and structural studies is discussed.
TidsskriftInternational Journal of Polymer Analysis & Characterization
Udgave nummer1
Sider (fra-til)13-22
Antal sider10
StatusUdgivet - 2007

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