Brain derived neurotrophic factor: Epigenetic regulation in psychiatric disorders

Cathy Mitchelmore, Lene Gede

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstract

    Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are currently being investigated in animal models and clinical studies. However, very little is currently known about the mechanisms that deregulate BDNF gene expression in these disorders. The BDNF gene structure and tissue expression pattern is complex, controlled in humans by 9 different gene promoters. Recently, epigenetic changes at the BDNF gene locus have been proposed to provide a link between gene and environment. In this review, we will summarize the current knowledge of BDNF epigenetic regulation with respect to psychiatric disorders and describe how this information can be applied in therapy and future research
    OriginalsprogEngelsk
    TidsskriftBrain Research
    Vol/bind1586
    Sider (fra-til)162-172
    ISSN0006-8993
    DOI
    StatusUdgivet - 24 okt. 2014

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